{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:32:14Z","timestamp":1780417934827,"version":"3.54.1"},"reference-count":49,"publisher":"The Korean Association for the Study of the Liver","issue":"3","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003665","name":"National IT Industry Promotion Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","award":["S0252-21-1001"],"award-info":[{"award-number":["S0252-21-1001"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000404","name":"Liver Research Foundation of Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000404","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["e-cmh.org"],"crossmark-restriction":true},"short-container-title":["Clin Mol Hepatol"],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:p>Background\/Aims: Chronic hepatitis B (CHB) is a risk factor for non-Hodgkin lymphoma (NHL). Our recent study suggested that antiviral treatment may reduce the incidence of NHL in CHB patients. This study compared the prognoses of hepatitis B virus (HBV)-associated diffuse large B-cell lymphoma (DLBCL) patients receiving antiviral treatment and HBV-unassociated DLBCL patients.Methods: This study comprised 928 DLBCL patients who were treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) at two referral centers in Korea. All patients with CHB received antiviral treatment. Time-to-progression (TTP) and overall survival (OS) were the primary and secondary endpoints, respectively.Results: Among the 928 patients in this study, 82 were hepatitis B surface antigen (HBsAg)-positive (the CHB group) and 846 were HBsAg-negative (the non-CHB group). The median follow-up time was 50.5 months (interquartile range [IQR]=25.6\u201369.7 months). Multivariable analyses showed longer TTP in the CHB group than the non-CHB group both before inverse probability of treatment weighting (IPTW; adjusted hazard ratio [aHR]=0.49, 95% confidence interval [CI]=0.29\u20130.82, p=0.007) and after IPTW (aHR=0.42, 95% CI=0.26\u20130.70, p&lt;0.001). The CHB group also had a longer OS than the non-CHB group both before IPTW (HR=0.55, 95% CI=0.33\u20130.92, log-rank p=0.02) and after IPTW (HR=0.53, 95% CI=0.32\u20130.99, log-rank p=0.02). Although liver-related deaths did not occur in the non-CHB group, two deaths occurred in the CHB group due to hepatocellular carcinoma and acute liver failure, respectively.Conclusions: Our findings indicate that HBV-associated DLBCL patients receiving antiviral treatment have significantly longer TTP and OS after R-CHOP treatment than HBV-unassociated DLBCL patients.<\/jats:p>","DOI":"10.3350\/cmh.2023.0057","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T23:32:22Z","timestamp":1684366342000},"page":"794-809","update-policy":"https:\/\/doi.org\/10.3350\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Treated chronic hepatitis B is a good prognostic factor of diffuse large B-cell lymphoma"],"prefix":"10.3350","volume":"29","author":[{"given":"Jeayeon","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Won","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Bin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjae","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Haeng","family":"Hur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heejin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Kyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonghwan","family":"Youk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Ok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hwan","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-4426","authenticated-orcid":true,"given":"Tae Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-2080","authenticated-orcid":true,"given":"Jeong-Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1902","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.016"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2021.0019"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2023.0070"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-021-00396-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0845-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(10)70167-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069400"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200\/jco.21.01285"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2023.0079"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgu010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.33.3252"},{"key":"ref12","volume-title":"","author":"Swerdlow","year":"2008"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200011)62:3<299::aid-jmv1>3.0.co;2-0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2019.1002"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29800"},{"key":"ref19","first-page":"940","volume-title":"KASL clinical practice guidelines for management of chronic hepatitis B. 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