{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:35:38Z","timestamp":1791495338400,"version":"4.3.4"},"reference-count":26,"publisher":"The Korean Association for the Study of the Liver","issue":"1","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"tdm","delay-in-days":316,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100016275","name":"Seoul National University Bundang Hospital","doi-asserted-by":"publisher","award":["SNUBH 02-2018-011"],"award-info":[{"award-number":["SNUBH 02-2018-011"]}],"id":[{"id":"10.13039\/100016275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016147","name":"The Korean Association for the Study of the Liver","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100016147","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Korean Liver Foundation"}],"content-domain":{"domain":["e-cmh.org"],"crossmark-restriction":true},"short-container-title":["Clin Mol Hepatol"],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:p>Background\/Aims: The histological criteria in the 1999 and 2008 scoring systems proposed by the International Autoimmune Hepatitis Group (IAIHG) have their inherent limitations in diagnosing autoimmune hepatitis (AIH). In this study, we evaluated the histology components of four scoring systems (1. revised original scoring system [\u201c1999 IAIHG\u201d], 2. simplified scoring system [\u201c2008 IAIHG\u201d], 3. modified histologic criteria [\u201c2017 UCSF\u201d], and 4. a new histologic criteria proposed by the International AIH Pathology Group [\u201c2022 IAHPG\u201d]) in AIH patients.Methods: Medical records and liver biopsies were retrospectively reviewed for 68 patients from two independent medical institutions, diagnosed with AIH based on the 1999 IAIHG system between 2006 and 2016. The histological features were reviewed in detail, and the four histological scoring systems were compared.Results: Out of the 68 patients, 56 (82.4%) patients met the \u201cprobable\u201d or \u201cdefinite\u201d AIH criteria of the 2008 IAIHG system, and the proportion of histologic score 2 (maximum) was 40\/68 (58.8%). By applying the 2017 UCSF criteria, the number of histology score 2 increased to 60\/68 (88.2%), and \u201cprobable\u201d or \u201cdefinite\u201d AIH cases increased to 61\/68 (89.7%). Finally, applying the 2022 IAHPG histology score resulted in the highest number of cases with histologic score 2 (64\/68; 94.1%) and with a diagnosis of \u201cprobable\u201d or \u201cdefinite\u201d AIH (62\/68; 91.2%).Conclusions: The recently proposed UCSF\/IAHPG histological criteria increased the histology score of AIH. Substituting the histology component of the 2008 IAIHG system with the 2022 IAHPG criteria increased the sensitivity for diagnosing AIH (\u2265\u201cProbable AIH\u201d) from 82.4% to 91.2%.<\/jats:p>","DOI":"10.3350\/cmh.2023.0325","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:05:32Z","timestamp":1699841132000},"page":"37-48","update-policy":"https:\/\/doi.org\/10.3350\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of four histological scoring systems for autoimmune hepatitis to improve diagnostic sensitivity"],"prefix":"10.3350","volume":"30","author":[{"given":"Soomin","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-7990","authenticated-orcid":true,"given":"Sook-Hyang","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ju","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoungbun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilhyang","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4205-9081","authenticated-orcid":true,"given":"Haeryoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1902","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0387"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(99)80297-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22322"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180435"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2023.0087"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.267"},{"key":"ref8","first-page":"1058","volume-title":"Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology","author":"Lohse","year":"2022"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80226-6"},{"key":"ref10","first-page":"1409","volume-title":"Chronic hepatitis. 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