{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:42:06Z","timestamp":1788219726085,"version":"build-2803163510"},"reference-count":50,"publisher":"The Korean Association for the Study of the Liver","issue":"Suppl","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6-2023-0097"],"award-info":[{"award-number":["6-2023-0097"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-cmh.org"],"crossmark-restriction":true},"short-container-title":["Clin Mol Hepatol"],"published-print":{"date-parts":[[2024,9,30]]},"abstract":"<jats:p>Backgrounds\/Aims: Accurate diagnosis of significant liver fibrosis in patients with chronic hepatitis B (CHB) is crucial when determining whether to initiate antiviral treatment (AVT). We conduct a meta-analysis to assess the diagnostic performance of vibration-controlled transient elastography (VCTE) for significant liver fibrosis in AVT-na\u00efve CHB patients with serum alanine transaminase (ALT) levels within 5-fold the upper limit of normal (ULN).Methods: The Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases were searched to identify studies that compared the performance of VCTE and liver biopsy (reference standard) when diagnosing significant liver fibrosis (\u2265F2) in AVT-na\u00efve CHB patients with ALT within 5-fold the ULN. A hierarchical summary receiver operating characteristic curve (HSROC) and bivariate model were performed to evaluate the diagnostic performance of VCTE in the meta-analysis.Results: Eight studies (2,003 patients) were included. The summary sensitivity and specificity for diagnosis of significant liver fibrosis were 0.78 (95% confidence interval [CI], 0.66\u20130.86) and 0.72 (95% CI, 0.60\u20130.82), respectively. The HSROC for the diagnosis of significant liver fibrosis was 0.81 (95% CI, 0.72\u20130.86). The optimal cutoff value of VCTE for diagnosis of significant liver fibrosis was 7.7 kPa with a sensitivity of 0.64 (95% CI, 0.50\u20130.76) and specificity of 0.83 (95% CI, 0.72\u20130.90).Conclusions: Our study demonstrated that VCTE has an acceptable diagnostic performance for significant liver fibrosis in AVT-na\u00efve CHB patients with ALT within 5-fold the ULN.<\/jats:p>","DOI":"10.3350\/cmh.2024.0371","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T23:27:45Z","timestamp":1721777265000},"page":"S106-S116","update-policy":"https:\/\/doi.org\/10.3350\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Vibration-controlled transient elastography for significant fibrosis in treatment-na\u00efve chronic hepatitis B patients: A systematic review and meta-analysis"],"prefix":"10.3350","volume":"30","author":[{"given":"Mi 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