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Our research highlights the antifibrotic potential of placenta-derived mesenchymal stem cells (PD-MSCs) and the role of phosphatase of regenerating liver-1 (PRL-1) in promoting liver regeneration.Methods: We evaluated the efficacy of PD-MSCs overexpressing PRL-1 (PD-MSCsPRL-1) in a bile duct ligationinduced rat injury model, focusing on their ability to regulate EMT.Results: PD-MSCsPRL-1 significantly reduced mesenchymal markers by downregulating TGFB1\/SMAD2, outperforming na\u00efve PD-MSCs. The transplantation of PD-MSCsPRL-1 enhanced BMP7\/SMAD1\/5 expression, promoting epithelial marker expression and stimulating BMP7 within hepatocytes, modulating downstream SMAD signaling. Importantly, further validation confirmed that PRL-1 directly interacts with BMP7 in hepatocytes.Conclusions: PRL-1 expression in PD-MSCsPRL-1 restores TGFB1\/BMP7 balance, promoting hepatic regeneration through mesenchymal-to-epithelial transition. These findings highlight the therapeutic potential of engineered MSCs for liver disease and suggest innovative strategies for future stem cell therapies.<\/jats:p>","DOI":"10.3350\/cmh.2024.0741","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T02:45:07Z","timestamp":1737513907000},"page":"823-840","update-policy":"https:\/\/doi.org\/10.3350\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Modulation of phosphatase of regenerating liver-1 within placental mesenchymal stem cells instigates the transition between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition subsequent to hepatic fibrosis"],"prefix":"10.3350","volume":"31","author":[{"given":"Jae Yeon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeri","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo 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