{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:15:44Z","timestamp":1793070944142,"version":"4.5.0"},"reference-count":42,"publisher":"The Korean Association for the Study of the Liver","issue":"Suppl","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"name":"Gilead"}],"content-domain":{"domain":["e-cmh.org"],"crossmark-restriction":true},"short-container-title":["Clin Mol Hepatol"],"published-print":{"date-parts":[[2025,2,28]]},"abstract":"<jats:p>Acute hepatitis E virus (HEV) infection is typically self-limiting and has a favourable prognosis. However, certain populations such as patients with pre-existing chronic liver disease may experience severe manifestations, including progression to acute-on-chronic liver failure (ACLF). Among viral hepatitis types, hepatitis A, E, and B are major causes of ACLF. Active screening and early diagnosis of HEV infection in patients with cirrhosis, especially those who develop ACLF, can improve management and enable timely antiviral therapy. Preventive measures, including HEV vaccination for high-risk groups, could reduce the morbidity and mortality associated with hepatitis E.<\/jats:p>","DOI":"10.3350\/cmh.2024.0758","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T02:37:33Z","timestamp":1731292653000},"page":"S196-S204","update-policy":"https:\/\/doi.org\/10.3350\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Hepatitis E as a trigger for acute-on-chronic liver failure"],"prefix":"10.3350","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0732-3078","authenticated-orcid":true,"given":"Maria","family":"Buti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Ruiz-Cobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Riveiro-Barciela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1902","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i14.1405"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/v15061389"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2013.08.009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3201\/eid1808.111827"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13557"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.34856"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05243.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13754"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2022.100878"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-010-9204-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-005-1781-y"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2013.08.013"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2019.04.050"},{"key":"ref15","first-page":"50","volume-title":"Hepatitis E virus is a leading cause of acute-on-chronic liver disease: experience from a tertiary centre in Bangladesh","author":"Mahtab","year":"2009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02521.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12610"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13309"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13484"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.01.012"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07050-w"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01887.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(11)61849-7"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15704"},{"key":"ref25","first-page":"1097","volume-title":"PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis","author":"Trebicka","year":"2021"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(07)60595-9"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2007.00858.x"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.021"},{"key":"ref29","first-page":"353","volume-title":"Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update","author":"Sarin","year":"2019"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14468"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2021.20502"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i19.6341"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2011.03.007"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1097\/hep.0000000000000701"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.3851\/imp2317"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.01.009"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12911"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(10)61030-6"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(23)02234-1"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(22)00421-2"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(23)00547-0"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.024"}],"container-title":["Clinical and Molecular Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-cmh.org\/upload\/pdf\/cmh-2024-0758.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-cmh.org\/journal\/view.php?doi=10.3350\/cmh.2024.0758","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-cmh.org\/upload\/pdf\/cmh-2024-0758.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T01:17:20Z","timestamp":1741828640000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-cmh.org\/journal\/view.php?doi=10.3350\/cmh.2024.0758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":42,"journal-issue":{"issue":"Suppl","published-print":{"date-parts":[[2025,2]]}},"URL":"https:\/\/doi.org\/10.3350\/cmh.2024.0758","relation":{},"ISSN":["2287-2728","2287-285X"],"issn-type":[{"value":"2287-2728","type":"print"},{"value":"2287-285X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"assertion":[{"value":"2024-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-28","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}