{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T19:02:36Z","timestamp":1787943756464,"version":"build-2784847793"},"reference-count":31,"publisher":"The Korean Association for the Study of the Liver","issue":"3","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Ildong Pharmaceutical Co."},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00217123"],"award-info":[{"award-number":["RS-2023-00217123"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["e-cmh.org"],"crossmark-restriction":true},"short-container-title":["CMH"],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:p>Background\/Aims: Besifovir (BSV) showed comparable antiviral activity and superior safety profiles to tenofovir disoproxil fumarate (TDF) in treatment-na\u00efve chronic hepatitis B (CHB). However, no data are available regarding the antiviral efficacy and safety of BSV in patients with CHB who switched from long-term TDF to BSV. This study aimed to evaluate the outcome of a 48-week BSV therapy in patients with CHB who switched from long-term TDF treatment.Methods: In this non-inferiority trial, 153 CHB patients treated with TDF for \u226548 weeks who had hepatitis B virus (HBV) DNA &lt;20 IU\/mL were randomized to receive either BSV 150 mg or TDF 300 mg for 48 weeks.Results: The per-protocol analysis included 130 patients (BSV group, 64; TDF group, 66). The median duration of TDF use before enrollment was 4.14 years. After 48 weeks, 100.0% and 98.5% patients in the BSV and TDF groups, respectively, met the primary endpoint (HBV DNA &lt;20 IU\/mL), demonstrating the non-inferior antiviral efficacy of BSV to TDF (95% confidence interval \u20130.01 to 0.04; P&gt;0.999), with a predefined margin of \u20130.18. The mean percentage changes in estimated glomerular filtration rates were slightly better in the BSV group (1.67\u00b111.73%) than in the TDF group (\u20131.24\u00b111.02%). The BSV group showed a significant improvement in bone turnover biomarkers compared to the TDF group; accordingly, hip and spine bone mineral density increased in the BSV group.Conclusions: In patients with CHB receiving long-term TDF, switching to BSV may improve renal and bone safety with non-inferior antiviral efficacy compared to that of maintaining TDF.<\/jats:p>","DOI":"10.3350\/cmh.2024.0819","type":"journal-article","created":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T19:27:47Z","timestamp":1737314867000},"page":"810-822","update-policy":"https:\/\/doi.org\/10.3350\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Switching to besifovir in patients with chronic hepatitis B receiving tenofovir disoproxil fumarate: A randomized trial"],"prefix":"10.3350","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6036-2754","authenticated-orcid":true,"given":"Hyung 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