{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:32:32Z","timestamp":1790793152040,"version":"4.1.0"},"reference-count":43,"publisher":"Inter-Research Science Center","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.int-res.com\/journals\/terms-of-use\/"}],"content-domain":{"domain":["int-res.com"],"crossmark-restriction":false},"short-container-title":["Dis. Aquat. Org."],"published-print":{"date-parts":[[2021,6,17]]},"abstract":"<jats:p>White spot syndrome virus (WSSV) is the most destructive virus among invertebrates. In this study, we analyzed the immune response after WSSV infection in Pacific white shrimp <jats:italic>Litopenaeus vannamei<\/jats:italic> using isobaric tags for relative and absolute quantitation (iTRAQ). We identified 325 differentially expressed proteins (DEPs) in the hepatopancreas of <jats:italic>L. vannamei<\/jats:italic>. Among them, 212 were up-regulated proteins, and several of them might be related to immunity (e.g. arginine kinase and peroxiredoxin). Of the 113 down-regulated proteins, some were related to immunity (e.g. cathepsin C and cathepsin L) and others to the antioxidant defense process (e.g. glutathione peroxidase and catalase). One down-regulated DEP (C7M84_014268) and 3 up-regulated DEPs (C7M84_003456, C7M84_020702, and C7M84_007135) were randomly selected and analyzed using parallel reaction monitoring. This study is an important step for a comprehensive understanding of the immune relationship between <jats:italic>L. vannamei<\/jats:italic> and WSSV and provides valuable information for the prevention of viral diseases in the crustacean aquaculture industry.<\/jats:p>","DOI":"10.3354\/dao03594","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T19:44:08Z","timestamp":1615405448000},"page":"51-61","update-policy":"https:\/\/doi.org\/10.3354\/policy","source":"Crossref","is-referenced-by-count":7,"title":["iTRAQ-based quantitative proteomic analysis of differentially expressed proteins in the hepatopancreas of Litopenaeus vannamei after WSSV infection"],"prefix":"10.3354","volume":"145","author":[{"given":"Y","family":"Zhai","sequence":"first","affiliation":[{"name":"College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai 201306, PR 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