{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:47:39Z","timestamp":1792709259735,"version":"4.5.0"},"reference-count":67,"publisher":"Inter-Research Science Center","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["int-res.com"],"crossmark-restriction":false},"short-container-title":["Dis. Aquat. Org."],"published-print":{"date-parts":[[2022,2,24]]},"abstract":"<jats:p><jats:italic>Brucella ceti<\/jats:italic> infection is associated with a variety of disease outcomes in cetaceans globally. Multiple genotypes of <jats:italic>B. ceti<\/jats:italic> have been identified. This retrospective aimed to determine if specific lesions were associated with different <jats:italic>B. ceti<\/jats:italic> DNA sequence types (STs). Characterization of ST was performed on 163 samples from 88 free-ranging cetaceans, including common bottlenose dolphin <jats:italic>Tursiops truncatus<\/jats:italic> (<jats:italic>T.t.<\/jats:italic>; n = 73), common short-beaked dolphin <jats:italic>Delphinus delphis<\/jats:italic> (<jats:italic>D.d<\/jats:italic>.; n = 7), striped dolphin <jats:italic>Stenella coeruleoalba<\/jats:italic> (n = 3), Pacific white-sided dolphin <jats:italic>Lagenorhynchus obliquidens<\/jats:italic> (n = 2), sperm whale <jats:italic>Physeter macrocephalus<\/jats:italic> (n = 2), and harbour porpoise <jats:italic>Phocoena phocoena<\/jats:italic> (n = 1), that stranded along the coast of the US mainland and Hawaii. ST was determined using a previously described insertion sequence 711 quantitative PCR. Concordance with 9-locus multi-locus sequence typing was assessed in a subset of samples (n = 18). ST 26 was most commonly identified in adult dolphins along the US east coast with non-suppurative meningoencephalitis (p = 0.009). Animals infected with ST 27 were predominately perinates that were aborted or died shortly after birth with evidence of <jats:italic>in utero<\/jats:italic> pneumonia (p = 0.035). Reproductive tract inflammation and meningoencephalitis were also observed in adult <jats:italic>T.t.<\/jats:italic> and <jats:italic>D.d.<\/jats:italic> with ST 27, though low sample size limited interpretation. ST 23 infections can cause disease in cetacean families other than porpoises (Phocoenidae), including neurobrucellosis in <jats:italic>D.d<\/jats:italic>. In total, 11 animals were potentially infected with multiple STs. These data indicate differences in pathogenesis among <jats:italic>B. ceti<\/jats:italic> STs in free-ranging cetaceans, and infection with multiple STs is possible.<\/jats:p>","DOI":"10.3354\/dao03644","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T11:21:44Z","timestamp":1639048904000},"page":"57-72","update-policy":"https:\/\/doi.org\/10.3354\/policy","source":"Crossref","is-referenced-by-count":16,"title":["Brucella ceti sequence type 23, 26, and 27 infections in North American cetaceans"],"prefix":"10.3354","volume":"148","author":[{"given":"JB","family":"Curtiss","sequence":"first","affiliation":[{"name":"Zoological Pathology Program, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Brookfield, IL 60513, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KM","family":"Colegrove","sequence":"additional","affiliation":[{"name":"Zoological Pathology Program, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Brookfield, IL 60513, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Dianis","sequence":"additional","affiliation":[{"name":"Zoological Pathology Program, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Brookfield, IL 60513, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MJ","family":"Kinsel","sequence":"additional","affiliation":[{"name":"Zoological Pathology Program, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Brookfield, IL 60513, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Zoological Pathology Program, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Brookfield, IL 60513, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Fauquier","sequence":"additional","affiliation":[{"name":"National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Office of Protected Resources, Silver Spring, MD 20910, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Rowles","sequence":"additional","affiliation":[{"name":"National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Office of Protected Resources, Silver Spring, MD 20910, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"International Fund for Animal Welfare, Yarmouth Port, MA 02675, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DS","family":"Rotstein","sequence":"additional","affiliation":[{"name":"Marine Mammal Pathology Services, Olney, MD 20832, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CW","family":"Maddox","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KA","family":"Terio","sequence":"additional","affiliation":[{"name":"Zoological Pathology Program, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Brookfield, IL 60513, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1913","reference":[{"key":"Ref1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.6379"},{"key":"Ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2013.01.023"},{"key":"Ref3","doi-asserted-by":"publisher","DOI":"10.2174\/1574891X11308010005"},{"key":"Ref4","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.11.2660-2666.1994"},{"key":"Ref5","doi-asserted-by":"publisher","DOI":"10.1177\/0300985817707023"},{"key":"Ref6","doi-asserted-by":"publisher","DOI":"10.1638\/2012-0195R.1"},{"key":"Ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(03)00091-1"},{"key":"Ref8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05238-11"},{"key":"Ref9","doi-asserted-by":"publisher","DOI":"10.3354\/dao02969"},{"key":"Ref10","unstructured":"Colegrove KM, Fauquier D, Terio K, Quance C and others (2016) Brucella infections in North American cetaceans: pathology, genetics, and unanswered epidemiologic questions. 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