{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T15:59:51Z","timestamp":1746806391329,"version":"3.40.5"},"reference-count":9,"publisher":"Inter-Research Science Center","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.int-res.com\/journals\/terms-of-use\/"}],"content-domain":{"domain":["int-res.com"],"crossmark-restriction":false},"short-container-title":["Dis. Aquat. Org."],"published-print":{"date-parts":[[2023,2,16]]},"abstract":"<jats:p>Managed care of cephalopods can be complicated by numerous factors including infectious and non-infectious disease, environmental stressors, and anatomic and physiological changes associated with senescence. The current report describes a unique case of nephrolithiasis in a senescent, &gt;2 yr old female Pacific octopus <jats:italic>Enteroctopus dofleini<\/jats:italic> housed in a public aquarium. Clinical signs included generalized external pallor, inappetence progressing to anorexia, lethargy, and a slow healing mantle abrasion over a period of a year. Due to the animal\u2019s declining condition, humane euthanasia was elected. At necropsy, multiple, small, approximately 1-5 mm diameter crystalline deposits were reported throughout all sections of the renal appendages. Histopathology identified a large crystal expanding and rupturing a focal tubule, causing necrosis, ulceration, and hemocytic infiltration. Crystalline stone analysis revealed that the nephrolith was composed of 100% ammonium acid urate. Additional changes to the digestive gland included marked atrophy with fibrosis correlated to the animal\u2019s history of hyporexia\/anorexia secondary to senescence. To our knowledge, this is the first report of nephrolithiasis in <jats:italic>E. dofleini<\/jats:italic>.<\/jats:p>","DOI":"10.3354\/dao03719","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T10:11:32Z","timestamp":1673518292000},"page":"45-49","update-policy":"https:\/\/doi.org\/10.3354\/policy","source":"Crossref","is-referenced-by-count":0,"title":["Nephrolithiasis in a giant Pacific octopus Enteroctopus dofleini"],"prefix":"10.3354","volume":"153","author":[{"given":"SM","family":"Hughes","sequence":"first","affiliation":[{"name":"Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, MS 39762, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Dunker","sequence":"additional","affiliation":[{"name":"Steinhart Aquarium, California Academy of Sciences, San Francisco, CA 94118, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"LaDouceur","sequence":"additional","affiliation":[{"name":"Joint Pathology Center, Silver Spring, MD 20910, USA"},{"name":"Zoetis Reference Laboratories, Salt Lake City, UT 84107, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1913","reference":[{"key":"Ref1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327604JAWS0504_02"},{"key":"Ref2","unstructured":"AZA AITAG (Association of Zoos and Aquariums Aquatic Invertebrate Taxon Advisory Group) (2014) Giant octopus (Enteroctopus dolfleini) care manual. Association of Zoos and Aquariums, Silver Springs, MD"},{"key":"Ref3","doi-asserted-by":"crossref","unstructured":"Dill-Okubo JA, Berzins IK, Camus AC, LaDouceur EE (2021) Mollusca cephalopoda. In: LaDouceur EE (ed) Invertebrate histology. Wiley Blackwell, Hoboken, NJ, p 133-162","DOI":"10.1002\/9781119507697.ch5"},{"key":"Ref4","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.10265"},{"key":"Ref5","doi-asserted-by":"crossref","unstructured":"Gestal C, Pascual S, Guerra A, Fiorito G, Vieites J (2019) Handbook of pathogens and disease in cephalopods. Springer Open, Cham","DOI":"10.1007\/978-3-030-11330-8"},{"key":"Ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0010-406X(65)90209-4"},{"key":"Ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0010-406X(65)90311-7"},{"key":"Ref8","doi-asserted-by":"crossref","unstructured":"Scimeca JM (2012) Cephalopods. In: Lewbart GA (ed) Invertebrate medicine. Wiley Blackwell, Hoboken, NJ, p 113-125","DOI":"10.1002\/9780470960806.ch7"},{"key":"Ref9","doi-asserted-by":"publisher","DOI":"10.1638\/2014-0134.1"}],"container-title":["Diseases of Aquatic Organisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.int-res.com\/articles\/dao2023\/153\/d153p045.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.int-res.com\/articles\/dao2023\/153\/d153p045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T12:57:58Z","timestamp":1676552278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.int-res.com\/abstracts\/dao\/v153\/p45-49\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":9,"URL":"https:\/\/doi.org\/10.3354\/dao03719","relation":{},"ISSN":["0177-5103","1616-1580"],"issn-type":[{"type":"print","value":"0177-5103"},{"type":"electronic","value":"1616-1580"}],"subject":[],"published":{"date-parts":[[2023,2,16]]}}}