{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T16:34:25Z","timestamp":1781368465146,"version":"3.54.1"},"reference-count":25,"publisher":"Inter-Research Science Center","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["int-res.com"],"crossmark-restriction":false},"short-container-title":["Dis. Aquat. Org."],"published-print":{"date-parts":[[2023,8,17]]},"abstract":"<jats:p>Glomerulocystic kidney (GCK) is defined by a dilatation of the Bowman\u2019s space (greater than 2 times the normal size) of more than 5% of all glomeruli. Although GCK has been occasionally documented in dogs, cats, and humans with renal failure, in fish, reports of spontaneous GCK are rare. For the present study, 2 captive adult red piranhas <jats:italic>Pygocentrus nattereri<\/jats:italic> from a closed population were submitted for post-mortem examination. Clinical history included lethargy, inappetence, dyspnea, and altered buoyancy. Macroscopically, the fish displayed coelomic distension and ascites. The kidneys were markedly enlarged and dark yellow. Histologically, Bowman\u2019s space was noticeably dilated, occasionally with atrophic glomerular tufts. Degeneration and necrosis of the tubular epithelium, infiltration, and nephrocalcinosis were also present. To the authors\u2019 knowledge, this present study is the first report of spontaneously occurring GCK in red piranhas and freshwater fish in general. Despite being rare, GCK is a condition with the potential to impair the health of fish and mammals, and further studies are needed to shed new light on this condition.<\/jats:p>","DOI":"10.3354\/dao03738","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T10:16:56Z","timestamp":1686219416000},"page":"73-78","update-policy":"https:\/\/doi.org\/10.3354\/policy","source":"Crossref","is-referenced-by-count":1,"title":["Glomerulocystic kidney in two red piranhas Pygocentrus nattereri"],"prefix":"10.3354","volume":"155","author":[{"given":"C","family":"de Sales-Ribeiro","sequence":"first","affiliation":[{"name":"Institute for Fish and Wildlife Health, University of Bern, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SRR","family":"Pisano","sequence":"additional","affiliation":[{"name":"Institute for Fish and Wildlife Health, University of Bern, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Diserens","sequence":"additional","affiliation":[{"name":"Institute for Fish and Wildlife Health, University of Bern, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Hoby","sequence":"additional","affiliation":[{"name":"Berne Animal Park, 3055 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Schmidt-Posthaus","sequence":"additional","affiliation":[{"name":"Institute for Fish and Wildlife Health, University of Bern, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1913","reference":[{"key":"Ref1","doi-asserted-by":"publisher","DOI":"10.4267\/2042\/67823"},{"key":"Ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1416-2"},{"key":"Ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(87)80093-8"},{"key":"Ref4","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014121217"},{"key":"Ref5","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394304-0.00011-7"},{"key":"Ref6","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004090754"},{"key":"Ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1697-5"},{"key":"Ref8","doi-asserted-by":"publisher","DOI":"10.2307\/1537258"},{"key":"Ref9","doi-asserted-by":"publisher","DOI":"10.1242\/dev.045500"},{"key":"Ref10","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.223.1780"},{"key":"Ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00730-2"},{"key":"Ref12","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-92691-7_9"},{"key":"Ref13","unstructured":"Larsen BK, Perkins EJ Jr (2001) Target organ toxicity in the kidney. In: Schlenk D, Benson WH (eds) Target organ toxicity in marine and freshwater teleosts. Taylor & Francis, London, p 102-164"},{"key":"Ref14","doi-asserted-by":"publisher","DOI":"10.5858\/134.4.583"},{"key":"Ref15","doi-asserted-by":"publisher","DOI":"10.1177\/030098588502200306"},{"key":"Ref16","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-06966-6.00004-0"},{"key":"Ref17","doi-asserted-by":"publisher","DOI":"10.1080\/usp.28.1.33.42"},{"key":"Ref18","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.42.4.285"},{"key":"Ref19","unstructured":"Reimschuessel R, Ferguson HW (2006) Kidney. In: Ferguson HW (ed) Systemic pathology of fish\u2014a text and atlas of normal tissues in teleosts and their responses in disease, 2nd edn. Scotian Press, London, p 91-120"},{"key":"Ref20","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049027"},{"key":"Ref21","unstructured":"Ross MH, Pawlina W (2016) Histology: a text and atlas with correlated cell and molecular biology, 7th edn. Wolters Kluwer, Philadelphia, PA"},{"key":"Ref22","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.3.1094-1104.2000"},{"key":"Ref23","unstructured":"Schmidt-Posthaus H (2017) Glomerulocystic kidney disease in a group of related turbot Scophthalmus maximus. In: Proc 13th EAFP Histopathology Workshop, Belfast, 3rd September 2018"},{"key":"Ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.11.025"},{"key":"Ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.664588"}],"container-title":["Diseases of Aquatic Organisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.int-res.com\/articles\/dao_oa\/d155p073.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.int-res.com\/articles\/dao_oa\/d155p073.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T13:18:34Z","timestamp":1692278314000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.int-res.com\/abstracts\/dao\/v155\/p73-78\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,17]]},"references-count":25,"URL":"https:\/\/doi.org\/10.3354\/dao03738","relation":{},"ISSN":["0177-5103","1616-1580"],"issn-type":[{"value":"0177-5103","type":"print"},{"value":"1616-1580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,17]]},"assertion":[{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}