{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T04:05:42Z","timestamp":1751601942974,"version":"3.41.0"},"reference-count":25,"publisher":"Inter-Research Science Center","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.int-res.com\/for-librarians\/reader-subscriber-license"}],"content-domain":{"domain":["int-res.com"],"crossmark-restriction":false},"short-container-title":["Dis. Aquat. Org."],"accepted":{"date-parts":[[2025,4,17]]},"abstract":"<jats:p>The Franciscana dolphin <jats:italic>Pontoporia blainvillei<\/jats:italic> is one of the most endangered cetaceans in the South Atlantic Ocean, primarily threatened due to bycatch. Knowledge regarding the natural causes of mortality and morbidity in this species is still limited. An adult female <jats:italic>P. blainvillei<\/jats:italic> that died as a result of bycatch was found stranded on the north coast of S\u00e3o Paulo, Brazil. At necropsy, a multi-cavitary tumor (~10.8 \u00d7 10.1 cm, 431 g) was found on the left adrenal gland, and on cut section, the tumor was hemorrhagic and necrotic. On histopathology, the tumor presented anaplastic characteristics including moderate anisocytosis and anisokaryosis, homogeneous and finely stippled chromatin, and nucleoli sometimes evident. Occasional binucleations and atypical giant cells were observed. The tumor was immunoreactive for chromogranin A and negative\/not immunoreactive for Factor VIII, CD31, pan-cytokeratin AE1\/AE3, vimentin, CD56, and synaptophysin, suggesting a poorly differentiated neuroendocrine tumor (NET). A moderate deviation of the lumbar spine (lordosis), lumbar ankylosing spondylosis, and thoracolumbar and caudal spine discopathy were confirmed via post-mortem radiographs. The vertebral anomalies and NET contribute to the knowledge of natural diseases of this endangered dolphin species.<\/jats:p>","DOI":"10.3354\/dao03858","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T05:43:59Z","timestamp":1746510239000},"page":"17-24","update-policy":"https:\/\/doi.org\/10.3354\/policy","source":"Crossref","is-referenced-by-count":0,"title":["Poorly differentiated neuroendocrine tumor and vertebral anomalies in a stranded Franciscana dolphin Pontoporia blainvillei"],"prefix":"10.3354","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6818-4609","authenticated-orcid":true,"given":"Ang\u00e9lica M","family":"S\u00e1nchez-Sarmiento","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia CCA","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9212-7778","authenticated-orcid":true,"given":"Raquel B","family":"Ferioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo A","family":"Ressio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rode P","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle F. 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S.","family":"Gagliotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Gallo-Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla B.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1913","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"Ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2020.02.013"},{"key":"Ref2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64821-8"},{"key":"Ref3","doi-asserted-by":"publisher","DOI":"10.1177\/104063879700900427"},{"key":"Ref4","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-5317-7.00002-3"},{"key":"Ref5","doi-asserted-by":"publisher","DOI":"10.1177\/030098589403100406"},{"key":"Ref6","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42-3-357"},{"key":"Ref7","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-45.1.19"},{"key":"Ref8","unstructured":"Geraci JR, Lounsbury VJ (1993) Marine mammals ashore: a field guide for strandings. 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Zool Meded 69:231-250"},{"key":"Ref14","unstructured":"K\u00f6pp LE, Castilho PV (2022) An\u00e1lise morfol\u00f3gica e osteom\u00e9trica da coluna vertebral da toninha (Pontoporia blainvillei). In: Semin\u00e1rio de Inicia\u00e7\u00e3o Cient\u00edfica. Universidade do Estado de Santa Catarina. 32\u00b0 SIC UDESC. https:\/\/www.udesc.br\/arquivos\/udesc\/id_cpmenu\/15663\/ANA_LISE_MORFOLO_GICA_E_OSTEOME_TRICA_DA_COLUNA_VERTEBRAL_DA_TONINHA__Pontoporia_blainvillei__16633479003212_15663.pdf"},{"key":"Ref15","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.06.27"},{"key":"Ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2881(08)60458-7"},{"key":"Ref17","unstructured":"MMA (Minist\u00e9rio do Meio Ambiente) (2022) Anexo 1. Lista oficial da fauna brasileira amea\u00e7ada de extin\u00e7\u00e3o. Portaria MMA N\u00b0 148, de 7 de junho de 2022. Dou 108, de 08 de junho de 2022. 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