{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T22:27:51Z","timestamp":1773354471736,"version":"3.50.1"},"reference-count":54,"publisher":"Inter-Research Science Center","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["int-res.com"],"crossmark-restriction":false},"short-container-title":["Dis. Aquat. Org."],"accepted":{"date-parts":[[2025,11,21]]},"abstract":"<jats:p>\n                    Nutrient deficiency can cause increased susceptibility to infectious diseases in fish, thus leading to high rates of morbidity and mortality. Thiamine deficiency complex (TDC) in fish can lead to low reproductive success and high mortality rates. Columnaris disease in salmonids, caused by\n                    <jats:italic>Flavobacterium columnare<\/jats:italic>\n                    , has resulted in devastating losses in aquaculture production and wild populations of Pacific salmon particularly associated with climate change and high water temperatures. There is growing awareness that both TDC and columnaris are emerging diseases of salmonids on the west coast of North America; however, it is unknown whether fish that survive from low\/intermediate thiamine level eggs will experience latent mortality due to susceptibility to infectious diseases like columnaris. To investigate the interaction of TDC survivors and columnaris, Chinook salmon\n                    <jats:italic>Oncorhynchus tshawytscha<\/jats:italic>\n                    fry reared from either thiamine-deficient (n = 120) or thiamine-replete (n = 120) eggs were challenged with\n                    <jats:italic>F. columnare<\/jats:italic>\n                    using an immersion challenge model of infection, and morbidity\/mortality, immune responses, and bacterial load were evaluated. The cumulative mortalities between the treatment groups were significantly different, with the thiamine-deficient,\n                    <jats:italic>F. columnare<\/jats:italic>\n                    -exposed fry ending the challenge with an 80.3% survival rate and the thiamine-replete,\n                    <jats:italic>F. columnare<\/jats:italic>\n                    -exposed fry ending with a 29.03% survival rate (p &lt; 0.0001). Different transcript abundance was detected in gills and spleen of thiamine-deficient and thiamine-replete fry exposed to\n                    <jats:italic>F. columnare.<\/jats:italic>\n                    This study demonstrated that fry reared from eggs low in thiamine have an altered immune response and warrants further studies to better understand interaction with potential pathogens at different life stages.\n                  <\/jats:p>","DOI":"10.3354\/dao03903","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T11:21:33Z","timestamp":1765192893000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.3354\/policy","source":"Crossref","is-referenced-by-count":0,"title":["Susceptibility to columnaris disease in Chinook salmon Oncorhynchus tshawytscha offspring from thiamine-deficient and thiamine-replete females"],"prefix":"10.3354","volume":"165","author":[{"given":"Taylor N","family":"Abraham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diem Thu","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeinab","family":"Yazdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather N","family":"Bell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E","family":"Todgham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Adkison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel C","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carson","family":"Jeffres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Foott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nann A","family":"Fangue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6382-8193","authenticated-orcid":true,"given":"Mark","family":"Fast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Rinchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarrod M","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1913","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"Ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-445X(00)00089-8"},{"key":"Ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cirep.2024.200144"},{"key":"Ref3","doi-asserted-by":"publisher","DOI":"10.1038\/srep38821"},{"key":"Ref4","unstructured":"Bennett M (2019) Wild salmon: protecting the icon of the Pacific Northwest. DU Quark 4:26-32"},{"key":"Ref5","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-85420-1_1"},{"key":"Ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2013.12.024"},{"key":"Ref7","unstructured":"Brown S, Honeyfield D (1998) Thiamine analysis in fish tissues. Am Fish Soc Symp 21:73-81"},{"key":"Ref8","doi-asserted-by":"publisher","DOI":"10.1577\/H08-025.1"},{"key":"Ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-017-0690-1"},{"key":"Ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02339"},{"key":"Ref11","unstructured":"CDFW (California Department of Fish and Wildlife) (2023) Chinook salmon. https:\/\/wildlife.ca.gov\/Conservation\/Fishes\/Chinook-Salmon"},{"key":"Ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-01734-w"},{"key":"Ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-11-11"},{"key":"Ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9716-44-27"},{"key":"Ref15","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.1.322-324.1997"},{"key":"Ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2017.10.048"},{"key":"Ref17","unstructured":"Farmer B (2004) Improved methods for the isolation and characterization of Flavobacterium columnare. MSc thesis. Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA"},{"key":"Ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jglr.2017.01.001"},{"key":"Ref19","doi-asserted-by":"publisher","DOI":"10.1641\/0006-3568(2002)052[0917:PSIAAT]2.0.CO;2"},{"key":"Ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50035-0"},{"key":"Ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2019.07.041"},{"key":"Ref22","doi-asserted-by":"publisher","DOI":"10.56808\/2985-1130.3081"},{"key":"Ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s11160-018-9538-x"},{"key":"Ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.01.009"},{"key":"Ref25","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H"},{"key":"Ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2021.02.017"},{"key":"Ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2008.12.011"},{"key":"Ref28","doi-asserted-by":"publisher","DOI":"10.3354\/dao02522"},{"key":"Ref29","unstructured":"Lall SP (2000) Nutrition and health of fish. In: Cruz-Su\u00e1rez LE, Ricque-Marie D, Tapia-Salazar M, Olvera-Novoa MA, Civera-Cerecedo R (eds) Avances en nutrici\u00f3n acu\u00edcola V. Memorias del V Simposium Internacional de Nutrici\u00f3n Acu\u00edcola, 19-22 Noviembre 2000, M\u00e9rida, Yucat\u00e1n, Mexico, p 13-23"},{"key":"Ref30","unstructured":"Lichatowich JJ (2001) Salmon without rivers: a history of the Pacific salmon crisis. Island Press, Washington, DC"},{"key":"Ref31","doi-asserted-by":"crossref","unstructured":"Mantua N, Johnson R, Field J, Lindley S and others (2021) Mechanisms, impacts, and mitigation for thiamine deficiency and early life stage mortality in California\u2019s Central Valley Chinook salmon. North Pacific Anadromous Fish Commission, p 92-93","DOI":"10.23849\/npafctr17\/92.93."},{"key":"Ref32","doi-asserted-by":"publisher","DOI":"10.1021\/bi401618y"},{"key":"Ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.aqrep.2023.101664"},{"key":"Ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s10021-001-0083-3"},{"key":"Ref35","unstructured":"NOAA (2020) Researchers probe deaths of Central Valley Chinook, with possible ties to ocean changes. NOAA Fisheries."},{"key":"Ref36","unstructured":"NOAA (2021) Monitoring thiamine deficiency in California salmon. NOAA Fisheries."},{"key":"Ref37","doi-asserted-by":"publisher","DOI":"10.1080\/08997659.2012.713890"},{"key":"Ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2014.03.024"},{"key":"Ref39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2109.2007.01695.x"},{"key":"Ref40","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-020-00852-3"},{"key":"Ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2019.09.052"},{"key":"Ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2014.08.029"},{"key":"Ref43","doi-asserted-by":"publisher","DOI":"10.1007\/s12562-020-01476-4"},{"key":"Ref44","doi-asserted-by":"publisher","DOI":"10.3354\/dao03588"},{"key":"Ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.08.003"},{"key":"Ref46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12010334"},{"key":"Ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2012.05.006"},{"key":"Ref48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219440"},{"key":"Ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2016.01.018"},{"key":"Ref50","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.11.6881-6886.2001"},{"key":"Ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2012.08.029"},{"key":"Ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2014.12.006"},{"key":"Ref53","doi-asserted-by":"crossref","unstructured":"Zou J, Secombes C (2016) The function of fish cytokines. Biology (Basel) 5:23","DOI":"10.3390\/biology5020023"},{"key":"Ref54","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.4.2484"}],"container-title":["Diseases of Aquatic Organisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.int-res.com\/articles\/dao_oa\/dao03903.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.int-res.com\/articles\/dao_oa\/dao03903.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:31:46Z","timestamp":1773315106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.int-res.com\/abstracts\/dao\/v165\/dao03903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,12]]},"references-count":54,"URL":"https:\/\/doi.org\/10.3354\/dao03903","archive":["CLOCKSS"],"relation":{},"ISSN":["0177-5103","1616-1580"],"issn-type":[{"value":"0177-5103","type":"print"},{"value":"1616-1580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,12]]},"assertion":[{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}