{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T08:33:18Z","timestamp":1781425998645,"version":"3.54.1"},"reference-count":0,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>Kryptor system was proven to be a rapid, standard method for\npregnancy-associated plasma protein A and proform eosinophilic\nmajor basic protein (PAPP-A\/proMBP) complex detection in\ncoronary artery disease (CAD). No age and\/or gender differences\nin 51 controls and 110 stable coronary artery disease (SCAD)\npatients were found. SCAD patients did not differ from controls\nand no difference in PAPP-A\/proMBP levels with regards to the\nnumber of affected vessels was found. In 21 unstable angina\npectoris (UAP), in 35 without and 66 with ST elevation acute\nmyocardial infarctions (NSTEMI, STEMI respectively) patients\nPAPP-A\/proMBP levels were increased (P=0.004 and P&lt;0.0005,\nrespectively). PAPP-A\/proMBP levels did not correlate with\ncardiac troponin I (cTnI) in STEMI and NSTEMI patients. PAPP-A\/\nproMBP increase was more frequent than cTnI (P=0.036) within\nthe early phase of STEMI. In NSTEMI patients PAPP-A\/proMBP\npositivity was present in 50 % of cTnI negative cases. Receiver\noperating characteristic (ROC) analysis revealed the highest\ndiagnostic accuracy of PAPP-A\/proMBP (0.919) in STEMI cTnI\npositive cases. The highest specificity\/sensitivity PAPP-A\/proMBP\nlevels for particular acute coronary syndrome (ACS) types were\n10.65-14.75 mIU\/l. Combination of PAPP-A\/proMBP with cTnI\nincreases their diagnostic efficacy within the early phase of ACS.\nOur results suggest that PAPP-A\/proMBP complex is involved in\nprocesses preceding vulnerable plaque development in ACS.<\/jats:p>","DOI":"10.33549\/physiolres.930986","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T15:08:10Z","timestamp":1618585690000},"page":"23-32","source":"Crossref","is-referenced-by-count":9,"title":["Pregnancy- associated plasma protein A and proform eosinophilic major basic protein in the detection of different types of coronary artery disease"],"prefix":"10.33549","author":[{"given":"P","family":"H\u00e1jek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Macek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hlad\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Houbov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Alan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Durdil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Fiedler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mal\u00fd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"O\u0161\u0165\u00e1dal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Veselka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Krebsov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2008]]},"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T15:08:11Z","timestamp":1618585691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/57\/57_23.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33549\/physiolres.930986","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2008]]}}}