{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T16:03:33Z","timestamp":1751472213623},"reference-count":0,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Statins, the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A\n(HMG-CoA) reductase, are most frequently used drugs in the\nprevention of coronary artery disease due to their cholesterollowering activity. However, it is not exactly known whether these\neffects of statins or those independent of cholesterol decrease\naccount for the protection against myocardial ischemiareperfusion (I\/R) injury. In this study, we investigated the effect\nof 5-day treatment with simvastatin (10 mg\/kg) in Langendorffperfused hearts of healthy control (C) and diabetichypercholesterolemic (D-H; streptozotocin + high fat-cholesterol\ndiet, 5 days) rats subjected to 30-min global ischemia followed\nby 40-min reperfusion for the examination of postischemic\ncontractile dysfunction and reperfusion-induced ventricular\narrhythmias or to 30-min (left anterior descending) coronary\nartery occlusion and 2-h reperfusion for the infarct size\ndetermination (IS; tetrazolium staining). Postischemic recovery of\nleft ventricular developed pressure (LVDP) in animals with D-H\nwas improved by simvastatin therapy (62.7\u00b118.2 % of\npreischemic values vs. 30.3\u00b15.7 % in the untreated D-H;\nP&lt;0.05), similar to the values in the simvastatin-treated C group,\nwhich were 2.5-fold higher than those in the untreated C group.\nNo ventricular fibrillation occurred in the simvastatin-treated C\nand D-H animals during reperfusion. Likewise, simvastatin\nshortened the duration of ventricular tachycardia (10.2\u00b18.1 s and\n57.8\u00b129.3 s in C and D-H vs. 143.6\u00b128.6 s and 159.3\u00b144.3 s in\nuntreated C and D-H, respectively, both P&lt;0.05). The decreased\narrhythmogenesis in the simvastatin-treated groups correlated\nwith the limitation of IS (in % of risk area) by 66 % and 62 % in\nC and D-H groups, respectively. However, simvastatin treatment\ndecreased plasma cholesterol levels neither in the D-H animals\nnor in C. The results indicate that other effects of statins\n(independent of cholesterol lowering) are involved in the\nimprovement of contractile recovery and attenuation of lethal I\/R\ninjury in both, healthy and diseased individuals.<\/jats:p>","DOI":"10.33549\/physiolres.931751","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T09:13:42Z","timestamp":1613639622000},"page":"449-454","source":"Crossref","is-referenced-by-count":20,"title":["Simvastatin alleviates myocardial contractile dysfunction and lethal ischemic injury in rat heart independent of cholesterol-lowering effects"],"prefix":"10.33549","author":[{"given":"A","family":"Adameov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Har\u010d\u00e1rov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Matej\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Pancza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ku\u017eelov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"\u010carnick\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"\u0160vec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bartekov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Styk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Ravingerov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2009]]},"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T09:13:42Z","timestamp":1613639622000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/58\/58_449.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33549\/physiolres.931751","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2009]]}}}