{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:24:56Z","timestamp":1776119096696,"version":"3.50.1"},"reference-count":0,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>The objective of this study was to assess a possible link between\nmicroalbuminuria (MA), a major risk factor of the cardiorenal\nsyndrome and the brain natriuretic peptide (BNP), a marker of\ncardiac hypertrophy. Two kidney-one clip (2K-1C) renovascular\nhypertension was induced in 24 male Wistar rats (weighing 220-\n250 g). Rats were randomized into four groups for 8 weeks:\nSham, not treated; Bos, treated with bosentan; Cap, treated with\ncaptopril; Bos\/Cap, treated with both drugs. Blood pressure,\nplasma BNP and transforming growth factor \u03b21 (TGF-\u03b21)\nconcentrations, microalbuminuria and creatininemia as well as\ncardiac mass, BNP, \u03b1- and \u03b2-myosin heavy chain (MHC) gene\nexpression and kidney histology were determined. Following\nstenosis, Sham rats developed hypertension (p&lt;0.001), an\nincrease in BNP (p&lt;0.05) and TGF-\u03b21 (p&lt;0.005) concentrations,\ncreatinine levels (p&lt;0.001), and urinary albumin (p&lt;0.001).\nUnder drug treatment, decreases in blood pressure (p&lt;0.001),\ncreatinine levels (p&lt;0.05), plasma TGF-\u03b21 (p&lt;0.005) and BNP\n(p&lt;0.05) concentrations, were concomitant with the absence of\nMA which was significantly correlated with reductions in cardiac\nmass (p&lt;0.05) and hypertrophy markers (BNP and \u03b2-MHC gene\nexpression) (p&lt;0.005) as well as in renal fibrosis. These findings\nsuggest a potential link between microalbuminuria evolution and\nBNP as well as a possible effect of microalbuminuria-lowering\ntherapy on halting the progression, or even inducing the\nregression of cardiac hypertrophy.<\/jats:p>","DOI":"10.33549\/physiolres.931826","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T13:41:54Z","timestamp":1612532514000},"page":"871-880","source":"Crossref","is-referenced-by-count":4,"title":["Microalbuminuria versus brain natriuretic peptide in cardiac hypertrophy of hypertensive rats"],"prefix":"10.33549","author":[{"given":"Y","family":"Saliba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Chouery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"M\u00e9garban\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Jabbour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Far\u00e8s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2010]]},"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T13:41:55Z","timestamp":1612532515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/59\/59_871.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33549\/physiolres.931826","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}