{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:11:04Z","timestamp":1776499864309,"version":"3.51.2"},"reference-count":0,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>At present, the supposed association between venous\nthromboembolism and atherosclerosis has yet to be proven.\nHowever, no data are available from patients with\nthrombophilias. We evaluated the association between preclinical\natherosclerosis and prevalence of thromboembolic events in\npatients with thrombophilias. Presence of preclinical\natherosclerosis in common carotid and femoral arteries measured\nby ultrasound was assessed by Belcaro score (based mainly on\nthe presence of plaques) and by measurements of intima media\nthickness in the same location in 109 patients (43 men, mean\nage 41.5\u00b113 years) with established thrombophilias. Other\nparameters under the study were age, presence of traditional\ncardiovascular risk factors, anthropometric and clinical data\nincluding blood pressure measurements and medication. The\ndifferences between patients with (n=47) and without (n=62)\nthromboembolic events were assessed by paired t-test and chi\nsquare tests. In patients with a history of venous thromboembolism, body mass index and the prevalence of antihypertensive treatment (AT) were significantly higher than in\npatients without history of thromboembolism (BMI: 26.5\u00b15.0 vs.\n24.4\u00b13.7 kg\/m2 ; p=0.04, AT: 25.5 % vs. 8.1 %; p=0.013). No significant differences between groups were found regarding preclinical atherosclerosis. Overweight and hypertension, but not preclinical atherosclerosis, were more prevalent in patients with\nthrombophilias suffering from thromboembolism.<\/jats:p>","DOI":"10.33549\/physiolres.931872","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T11:49:45Z","timestamp":1612266585000},"page":"721-728","source":"Crossref","is-referenced-by-count":2,"title":["Preclinical atherosclerosis and other determinants of venous thromboembolism in patients with thrombophilias"],"prefix":"10.33549","author":[{"given":"O","family":"Auzk\u00fd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Pag\u00e1\u010dov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"\u0160ejda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Pi\u0165ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2010]]},"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T16:11:21Z","timestamp":1612368681000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/59\/59_721.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33549\/physiolres.931872","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}