{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T07:08:37Z","timestamp":1723273717082},"reference-count":0,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Prague hereditary hypercholesterolemic (PHHC) rat \u2013 rat strain\ncrossbred from Wistar rats \u2013 is a model of hypercholesterolemia\ninduced by dietary cholesterol. Importantly, no bile salts and\/or\nantithyroid drugs need to be added to the diet together with\ncholesterol to induce hypercholesterolemia. PHHC rats have only\nmodestly increased cholesterolemia when fed a standard chow\nand develop hypercholesterolemia exceeding 5 mmol\/l on 2 %\ncholesterol diet. Most of the cholesterol in hypercholesterolemic\nPHHC rats is found in VLDL that become enriched with\ncholesterol (VLDL-C\/VLDL-TG ratio &gt; 1.0). Concurrently, both IDL\nand LDL concentrations rise without any increase in HDL. PHHC\nrats do not markedly differ from Wistar rats in the activities of\nenzymes involved in intravascular remodelation of lipoproteins\n(lipoprotein and hepatic lipases and lecithin:cholesterol\nacyltransferase), LDL catabolism, cholesterol turnover rate and\nabsorption of dietary cholesterol. The feeding rats with\ncholesterol diet results in development of fatty liver in spite of\nsuppression of cholesterol synthesis. However, even though\ncholesterolemia in PHHC rats is comparable to human\nhypercholesterolemia, the PHHC rats do not develop\natherosclerosis even after 6 months on 2 % cholesterol diet.\nImportantly, the crossbreeding experiments documented that\nhypercholesterolemia of PHHC rats is polygenic. To identify the\ngenes that may be involved in pathogenesis of\nhypercholesterolemia in this strain, the studies of microarray\ngene expression in the liver of PHHC rats are currently in\nprogress.<\/jats:p>","DOI":"10.33549\/physiolres.931916","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T13:27:50Z","timestamp":1615296470000},"page":"S95-S100","source":"Crossref","is-referenced-by-count":9,"title":["Prague hereditary hypercholesterolemic (PHHC) rat \u2013 a model of polygenic hypercholesterolemia"],"prefix":"10.33549","author":[{"given":"J","family":"Kov\u00e1\u0159","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Tonar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Heczkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Poledne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2009]]},"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T13:27:50Z","timestamp":1615296470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/58%20Suppl%202\/58_S95.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33549\/physiolres.931916","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2009]]}}}