{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:24:46Z","timestamp":1791188686764,"version":"4.1.0"},"reference-count":0,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Hemorrhagic shock (HS) represents an acute event with high\nmortality. The optimal combination of anesthetics that would\nprevent hemodynamic collapse and allow damage control surgery\nhas not yet been determined. We tested the hypothesis that a\ncombination of dissociative anesthetic ketamine with alpha2-\nagonist medetomidine (MK group, n=10) would provide superior\nhemodynamic control compared to propofol-remifentanil (PR\ngroup, n=10) during HS in minipigs. A modified Wiggers\u2018 model\nof HS with a target mean arterial pressure (MAP) of 40 mm Hg\nand 2 h duration was used. All minipigs survived. HS led to\na ~50 % decrease in cardiac output in both groups (P&lt;0.001 for\nbaseline vs. HS 120 min) with no differences between groups.\nTotal volume of removed blood was larger in the MK group\n(1321\u00b1133 ml vs. 1111\u00b1246 ml in the PR group, respectively;\nP&lt;0.05). MAP was higher during the initial phases of HS in the\nMK group than in PR group (P&lt;0.05 at HS 30-90 min). HR was\nlower in the MK group at the late phases of HS (P&lt;0.05 at HS\n60-120 min). In conclusion, medetomidine-ketamine provides a\nfeasible and possibly a more favorable alternative to the\npropofol-remifentanil combination in our model of HS in minipigs.<\/jats:p>","DOI":"10.33549\/physiolres.931927","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T11:49:35Z","timestamp":1612266575000},"page":"703-710","source":"Crossref","is-referenced-by-count":9,"title":["The effect of medetomidine-ketamine anesthesia on hemodynamic parameters during hemorrhagic shock in minipigs"],"prefix":"10.33549","author":[{"given":"A","family":"Brezina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Drabek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Riha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Schreiberova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2010]]},"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T16:11:10Z","timestamp":1612368670000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/59\/59_703.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33549\/physiolres.931927","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}