{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:33:59Z","timestamp":1789205639171,"version":"build-2803163510"},"reference-count":0,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Exercise training-induced cardiac hypertrophy occurs following a\nprogram of aerobic endurance exercise training and it is\nconsidered as a physiologically beneficial adaptation. To\ninvestigate the underlying biology of physiological hypertrophy,\nwe rely on robust experimental models of exercise training in\nlaboratory animals that mimic the training response in humans.\nA number of experimental strategies have been established, such\nas treadmill and voluntary wheel running and swim training\nmodels that all associate with cardiac growth. These approaches\nhave been applied to numerous animal models with various\nbackgrounds. However, important differences exist between\nthese experimental approaches, which may affect the\ninterpretation of the results. Here, we review the various\napproaches that have been used to experimentally study exercise\ntraining-induced cardiac hypertrophy; including the advantages\nand disadvantages of the various models.<\/jats:p>","DOI":"10.33549\/physiolres.931928","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T06:48:52Z","timestamp":1612248532000},"page":"633-644","source":"Crossref","is-referenced-by-count":75,"title":["Animal models in the study of exercise-induced cardiac hypertrophy"],"prefix":"10.33549","author":[{"given":"Y","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Wisloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OJ","family":"Kemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2010]]},"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T11:10:32Z","timestamp":1612350632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/59\/59_633.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33549\/physiolres.931928","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}