{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:01:01Z","timestamp":1791126061155,"version":"4.1.0"},"reference-count":0,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Chronic renal failure (CRF) is associated with high incidence of\ncardiovascular complications. To clarify pathogenesis of CRF\nnumerous animal models have been developed. The aim of our\nwork was to describe methodology of subtotal surgical renal\nablation in rat and to characterize some biochemical and\ncardiovascular parameters of this animal model. Male rats\nunderwent 5\/6 surgical nephrectomy or sham operations in two\nsteps. The following parameters were measured on day 10 and in\nweek 10 after the surgery: plasma concentrations of creatinine\nand urea, blood pressure, resting heart rate, chronotropic\nresponse to atropine and metipranol, heart ventricles weight,\ncontraction parameters and action potential duration in the left\nventricle. Increased serum concentrations of creatinine and urea,\ndecreased creatinine clearance, polyuria and alteration of the\nremnant kidney tissue were found in CRF rats. Changes in\ncardiovascular parameters identified after subtotal nephrectomy\nresembled alterations of cardiovascular system in uremic patients\nand included hypertension, elevated resting heart rate,\ndiminished parasympathetic cardiac tone, hypertrophy of the left\nventricle associated with weakened force of contraction,\nprolonged contraction and relaxation and shortening of action\npotential duration. These data suggest that the present model\ncan be a useful tool in the study of CRF and its cardiovascular\ncomplications.<\/jats:p>","DOI":"10.33549\/physiolres.932003","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T20:55:53Z","timestamp":1612731353000},"page":"S81-S88","source":"Crossref","is-referenced-by-count":32,"title":["Cardiovascular parameters in rat model of chronic renal failure induced by subtotal nephrectomy"],"prefix":"10.33549","author":[{"given":"J","family":"\u0160v\u00edglerov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kuncov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Nalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Tonar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Rajdl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"\u0160tengl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2010]]},"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T20:55:54Z","timestamp":1612731354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/59%20Suppl%201\/59_S81.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"URL":"https:\/\/doi.org\/10.33549\/physiolres.932003","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}