{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T20:56:45Z","timestamp":1776200205198,"version":"3.50.1"},"reference-count":34,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2012,2,28]]},"abstract":"<jats:p>Cardiovascular disease is a major cause of morbidity and mortality in young adults with end-stage renal disease (ESRD), but its basis is still not well understood. We therefore evaluated the determinants of atherosclerosis in children with ESRD. A total of 37 children with ESRD (with 31 who had undergone transplantation) were examined and compared to a control group comprising 22 healthy children. The common carotid intima-media thickness (CIMT) was measured by ultrasound as a marker of preclinical atherosclerosis. The association of CIMT with anthropometrical data, blood pressure, plasma lipid levels, and other biochemical parameters potentially related to cardiovascular disease was evaluated. Children with ESRD had significantly higher CIMT, blood pressure, and levels of lipoprotein (a), urea, creatinine, ferritin, homocysteine, and serum uric acid as well as significantly lower values of apolipoprotein A. The atherogenic index of plasma (log(triglycerides\/HDL cholesterol)) was also higher in patients with ESRD; however, this difference reached only borderline significance. In addition, a negative correlation was found between CIMT and serum albumin and bilirubin in the ESRD group, and this correlation was independent of age and body mass index. In the control group, a significant positive correlation was observed between CIMT and ferritin levels. Factors other than traditional cardiovascular properties, such as the anti-oxidative capacity of circulating blood, may be of importance during the early stages of atherosclerosis in children with end-stage renal disease.<\/jats:p>","DOI":"10.33549\/physiolres.932127","type":"journal-article","created":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T07:49:26Z","timestamp":1585381766000},"page":"53-61","source":"Crossref","is-referenced-by-count":10,"title":["Determinants of Premature Atherosclerosis in Children With End-Stage Renal Disease"],"prefix":"10.33549","author":[{"given":"H. 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Isr J Med Sci 32: 371-389, 1996."},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"LILIEN MR, STROES ES, OP\u2019T ROODT J, DE JONGH S, SCHRODER CH, KOOMANS HA: Vascular function in children after renal transplantation. Am J Kidney Dis 41: 684-691, 2003.","DOI":"10.1053\/ajkd.2003.50131"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"LITWIN M, W\u00dcHL E, JOURDAN C, TRELEWICZ J, NIEMIRSKA A, FAHR K, JOBS K, GRENDA R, WAWER ZT, RAJSZYS P, TR\u00d6GER J, MEHLS O, SCHAEFER F: Altered morphologic properties of large arteries in children with chronic renal failure and after renal transplantation. J Am Soc Nephrol 16: 1494-1500, 2005.","DOI":"10.1681\/asn.2004110932"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"MCDONALD SP, CRAIG JC, THE AUSTRALIAN AND NEW ZEALAND PAEDIATRIC NEPHROLOGY ASSOCIATION: Long-term survival of children with end-stage renal disease. 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J Neuroimaging 9: 19-22, 1999.","DOI":"10.1111\/jon19999119"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"POYRAZOGLU HM, D\u00dcS\u00dcNSEL R, YIKILMAZ A, NARIN N, ANARAT R, G\u00dcND\u00dcZ Z, COSKUN A, BAYKAN A, \u00d6ZT\u00dcRK A: Carotid artery thickness in children and young adults with end stage renal disease. Paediatr Nephrol 22: 109-116, 2007.","DOI":"10.1007\/s00467-006-0268-2"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"QUERFELD U: Disturbances of lipid metabolism in children with chronic renal failure. Pediatr Nephrol 7: 749-757, 1993.","DOI":"10.1007\/bf01213345"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"RAITAKARI OT: Imaging of subclinical atherosclerosis in children and young adults. Ann Med 31 (Suppl 1): 33-40, 1999.","DOI":"10.1080\/07853890.1999.11904397"},{"key":"ref25","unstructured":"RITZ E: Why are lipids not predictive of cardiovascular death in the dialysis patient? 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J Hypertens 16: 1593-1602, 1998.","DOI":"10.1097\/00004872-199816110-00005"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"SCHWARTZ GJ, HAYCOCK GB, EDELMANN CM Jr, SPITZER A: A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58: 259-263, 1976.","DOI":"10.1542\/peds.58.2.259"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"SEDLAK TW, SNYDER SH: Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics 113: 1776-1782, 2004.","DOI":"10.1542\/peds.113.6.1776"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"SEEMAN T, DUSEK J, VONDRAK K, SIMKOVA E, KREISINGER J, FEBER J, JANDA J: Ambulatory blood pressure monitoring in children after renal transplantation. Transplant Proc 36: 1355-1356, 2004.","DOI":"10.1016\/j.transproceed.2004.04.081"},{"key":"ref31","unstructured":"URBANOVA Z, SAMANEK M, CESKA R, CIFKOVA R, POLEDNE R, ROSOLOVA H, SOSKA V, SIMON J, VAVERKOVA H, WIDIMSKY J Jr, WIDIMSKY J Sr, ZADAK Z: Recommendations for the diagnosis and therapy of hyperlipoproteinemia in childhood and adolescence developed by the Committee of the Czech Society for Atherosclerosis. (in Czech) Cas Lek Cesk 137: 89-92, 1998."},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"WENDELHAG I, GUSTAVSSON T, SUURKULA M, BERGLUND G, WIKSTRAND J: Ultrasound measurement of wall thickness in the carotid artery: fundamental principles and description of a computerized analysing system. 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