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Astrocytes may play an active role during degeneration and demyelination by controlling local inflammation in the CNS, provoking damage of oligodendrocytes and axons, and glial scarring but might also be beneficial by creating a permissive environment for remyelination and oligodendrocyte precursor migration, proliferation, and differentiation. Recent findings from our lab suggest that brain lipid binding protein (FABP7) is implicated in the course of multiple sclerosis and the regulation of astrocyte function. The relevance of our findings and data from other groups are highlighted and discussed in this paper in the context of myelin repair.<\/jats:p>","DOI":"10.33549\/physiolres.932168","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T10:48:59Z","timestamp":1603882139000},"page":"S49-S60","source":"Crossref","is-referenced-by-count":35,"title":["Brain Lipid Binding Protein (FABP7) as Modulator of Astrocyte Function"],"prefix":"10.33549","author":[{"given":"M.","family":"KIPP","sequence":"first","affiliation":[{"name":"Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"CLARNER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"GINGELE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"POTT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"AMOR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"VAN DER VALK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"BEYER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2011,10,15]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ARNETT HA, MASON J, MARINO M, SUZUKI K, MATSUSHIMA GK, TING JP: TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. 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