{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T19:14:38Z","timestamp":1781723678247,"version":"3.54.5"},"reference-count":23,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2012,10,31]]},"abstract":"<jats:p>Fibroblast growth factor-21 (FGF-21) has been recently characterized as a new adipokine. The aim of this study was to assess FGF-21 levels in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and to study the relationship between FGF-21, disease activity and metabolic status. The levels of FGF-21 in serum and synovial fluid samples from 38 patients with RA and 42 control individuals with OA were determined by ELISA. Patients were assessed for disease activity using the disease activity score (DAS28), a serum glucose and lipid profile. Age, sex and BMI-adjusted FGF-21 levels in the serum (p=0.024) and synovial fluid (p=0.010) samples were significantly higher in patients with RA when compared with OA. The levels of FGF-21 in the serum significantly correlated with the levels in the synovial fluid. Serum and synovial fluid FGF-21 levels adjusted for confounders correlated positively with C-reactive protein. The levels of FGF-21 were positively correlated with BMI in patients with RA; however, the levels were not associated with disease activity or lipid profiles. Furthermore, serum FGF-21 levels were significantly higher in seropositive compared with seronegative RA patients. This work shows that patients with seropositive RA have increased levels of FGF-21. The results suggest that FGF-21 is related to BMI but not disease activity or lipid profiles in patients with RA.<\/jats:p>","DOI":"10.33549\/physiolres.932324","type":"journal-article","created":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T10:34:20Z","timestamp":1588502060000},"page":"489-494","source":"Crossref","is-referenced-by-count":22,"title":["Novel Adipokine Fibroblast Growth Factor 21 Is Increased in Rheumatoid Arthritis"],"prefix":"10.33549","author":[{"given":"H.","family":"HULEJOV\u00c1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"ANDR\u00c9S CEREZO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"KUKLOV\u00c1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"PECHA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"VONDR\u00c1\u010cEK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"PAVELKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"VENCOVSK\u00dd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"HALUZ\u00cdK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"\u0160ENOLT","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Rheumatology, Institute of Rheumatology, First Faculty of Medicine, Charles University, Prague"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2012,10,17]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ARNETT FC, EDWORTHY SM, BLOCH DA, MCSHANE DJ, FRIES JF, COOPER NS, HEALEY LA, KAPLAN SR, LIANG MH, LUTHRA HS, ET AL.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31: 315-324, 1988.","DOI":"10.1002\/art.1780310302"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"BEENKEN A, MOHAMMADI M: The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov 8: 235-253, 2009.","DOI":"10.1038\/nrd2792"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"BOKAREWA M, BOKAREW D, HULTGREN O, TARKOWSKI A: Leptin consumption in the inflamed joints of patients with rheumatoid arthritis. Ann Rheum Dis 62: 952-956, 2003.","DOI":"10.1136\/ard.62.10.952"},{"key":"ref3","unstructured":"DERDEMEZIS CS, VOULGARI PV, DROSOS AA, KIORTSIS DN: Obesity, adipose tissue and rheumatoid arthritis: coincidence or more complex relationship? Clin Exp Rheumatol 29: 712-727, 2011."},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"DOST\u00c1LOV\u00c1 I, KAV\u00c1LKOV\u00c1 P, HALUZ\u00cdKOV\u00c1 D, LACINOV\u00c1 Z, MR\u00c1Z M, PAPEZOV\u00c1 H, HALUZ\u00cdK M: Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa. J Clin Endocrinol Metab 93: 3627-3632, 2008.","DOI":"10.33549\/physiolres.932163"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"DOST\u00c1LOV\u00c1 I, HALUZ\u00cdKOV\u00c1 D, HALUZ\u00cdK M: Fibroblast growth factor 21: a novel metabolic regulator with potential therapeutic properties in obesity\/type 2 diabetes mellitus. Physiol Res 58: 1-7, 2009.","DOI":"10.33549\/physiolres.931610"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"DUROVCOV\u00c1 V, MAREK J, H\u00c1NA V, MATOULEK M, ZIK\u00c1N V, HALUZ\u00cdKOV\u00c1 D, KAV\u00c1LKOV\u00c1 P, LACINOV\u00c1 Z, KRSEK M, HALUZ\u00cdK M: Plasma concentrations of fibroblast growth factors 21 and 19 in patients with Cushing's syndrome. Physiol Res 59: 415-422, 2010.","DOI":"10.33549\/physiolres.933244"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"EHLING A, SCH\u00c4FFLER A, HERFARTH H, TARNER IH, ANDERS S, DISTLER O, PAUL G, DISTLER J, GAY S, SCH\u00d6LMERICH J, NEUMANN E, M\u00dcLLER-LADNER U: The potential of adiponectin in driving arthritis. J Immunol 176: 4468-4478, 2006.","DOI":"10.4049\/jimmunol.176.7.4468"},{"key":"ref8","unstructured":"FOJT\u00cdKOV\u00c1 M, TOMASOV\u00c1 STUD\u00ddNKOV\u00c1 J, FILKOV\u00c1 M, LACINOV\u00c1 Z, GATTEROV\u00c1 J, PAVELKA K, VENCOVSK\u00dd J, SENOLT L. Elevated prolactin levels in patients with rheumatoid arthritis: association with disease activity and structural damage. Clin Exp Rheumatol 28: 849-854, 2010."},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"KHARITONENKOV A, SHIYANOVA TL, KOESTER A, FORD AM, MICANOVIC R, GALBREATH EJ, SANDUSKY GE, HAMMOND LJ, MOYERS JS, OWENS RA, GROMADA J, BROZINICK JT, HAWKINS ED, WROBLEWSKI VJ, LI DS, MEHRBOD F, JASKUNAS SR, SHANAFELT AB: FGF-21 as a novel metabolic regulator. J Clin Invest 115: 1627-1635, 2005.","DOI":"10.1172\/jci23606"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"KHARITONENKOV A, WROBLEWSKI VJ, KOESTER A, CHEN YF, CLUTINGER CK, TIGNO XT, HANSEN BC, SHANAFELT AB, ETGEN GJ: The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology 148: 774-781, 2007.","DOI":"10.1210\/en.2006-1168"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"KOTULAK T, DRAPALOVA J, KOPECKY P, LACINOVA Z, KRAMAR P, RIHA H, NETUKA I, MALY J, HOUSA D, BLAHA J, SVACINA S, HALUZIK M: Increased circulating and epicardial adipose tissue mRNA expression of fibroblast growth factor-21 after cardiac surgery: a possible role in postoperative inflammatory response and insulin resistance. Physiol Res 60: 757-767, 2011.","DOI":"10.33549\/physiolres.932134"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"LIN Z, WU Z, YIN X, LIU Y, YAN X, LIN S, XIAO J, WANG X, FENG W, LI X: Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile. PLoS One 5: e15534, 2010.","DOI":"10.1371\/journal.pone.0015534"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"LIN Z, ZHOU Z, LIU Y, GONG Q, YAN X, XIAO J, WANG X, LIN S, FENG W, LI X: Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese. PLoS One 6: e18398, 2011.","DOI":"10.1371\/journal.pone.0018398"},{"key":"ref14","unstructured":"MCCAREY D, STURROCK RD: Comparison of cardiovascular risk in ankylosing spondylitis and rheumatoid arthritis. Clin Exp Rheumatol 27 (Suppl 55): 124-126, 2009."},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"MRAZ M, BARTLOVA M, LACINOVA Z, MICHALSKY D, KASALICKY M, HALUZIKOVA D, MATOULEK M, DOSTALOVA I, HUMENANSKA V, HALUZIK M: Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity. Clin Endocrinol (Oxf) 71: 369-375, 2009.","DOI":"10.1111\/j.1365-2265.2008.03502.x"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"NEUMANN E, FROMMER KW, VASILE M, M\u00dcLLER-LADNER U: Adipocytokines as driving forces in rheumatoid arthritis and related inflammatory diseases? Arthritis Rheum 63: 1159-1169, 2011.","DOI":"10.1002\/art.30291"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"SCOTT DL, WOLFE F, HUIZINGA TW: Rheumatoid arthritis. Lancet 376: 1094-1108, 2010.","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"SENOLT L, HOUSA D, VERNEROV\u00c1 Z, JIR\u00c1SEK T, SVOBODOV\u00c1 R, VEIGL D, ANDERLOV\u00c1 K, M\u00dcLLER-LADNER U, PAVELKA K, HALUZ\u00cdK M: Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum. Ann Rheum Dis 66: 458-463, 2007.","DOI":"10.1136\/ard.2006.054734"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"SENOLT L, POLANSK\u00c1 M, FILKOV\u00c1 M, CEREZO LA, PAVELKA K, GAY S, HALUZ\u00cdK M, VENCOVSKY J: Vaspin and omentin: new adipokines differentially regulated at the site of inflammation in rheumatoid arthritis. Ann Rheum Dis 69: 1410-1411, 2010.","DOI":"10.1136\/ard.2009.119735"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"SENOLT L, KRY\u0160T\u016eFKOV\u00c1 O, HULEJOV\u00c1 H, KUKLOV\u00c1 M, FILKOV\u00c1 M, CEREZO LA, B\u011aL\u00c1\u010cEK J, HALUZ\u00cdK M, FOREJTOV\u00c1 S, GAY S, PAVELKA K, VENCOVSK\u00dd J: The level of serum visfatin (PBEF) is associated with total number of B cells in patients with rheumatoid arthritis and decreases following B cell depletion therapy. Cytokine 55: 116-121, 2011a.","DOI":"10.1016\/j.cyto.2011.04.004"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"SENOLT L, KUKLOV\u00c1 M, CEREZO LA, HULEJOV\u00c1 H, FILKOV\u00c1 M, BOSANSK\u00c1 L, PECHA O, PAVELKA K, HALUZ\u00cdK M, VENCOVSKY J: Adipokine profile is modulated in subcutaneous adipose tissue by TNF{alpha} inhibitors in patients with rheumatoid arthritis. Ann Rheum Dis 70: 2054-2056, 2011b.","DOI":"10.1136\/ard.2011.152603"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"YILMAZ Y, EREN F, YONAL O, KURT R, AKTAS B, CELIKEL CA, OZDOGAN O, IMERYUZ N, KALAYCI C, AVSAR E: Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease. Eur J Clin Invest 40: 887-892, 2010.","DOI":"10.1111\/j.1365-2362.2010.02338.x"}],"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T08:36:50Z","timestamp":1615538210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/61\/61_489.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,17]]},"references-count":23,"URL":"https:\/\/doi.org\/10.33549\/physiolres.932324","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10,17]]}}}