{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T19:11:42Z","timestamp":1694805102395},"reference-count":32,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2012,8,31]]},"abstract":"<jats:p>Primary aldosteronism (PA) is the most common cause of endocrine hypertension with a high frequency of cardiovascular complications. We found in our previous study higher occurrence of metabolic disturbances in patients with idiopathic hyperaldosteronism (IHA) compared to subjects with aldosterone-producing adenoma (APA). The aim of our present study is to evaluate potential differences in the frequency of end-organ damage (arterial stiffness and microalbuminuria) between two main types of PA. The diagnosis of the particular form of PA was based on adrenal venous sampling and\/or histopathological examination. We analyzed clinical and laboratory data from 72 patients with PA (36 with IHA, 36 with APA). The arterial stiffness was expressed as the carotid-femoral pulse wave velocity (PWV) and the renal damage as urinary albumin excretion levels (UAE). Patients with IHA had significantly (p&lt;0.03) higher prevalence of metabolic syndrome (17 % in APA, 35 % in IHA), higher triglycerides (1.37\u00b10.71 mmol\/l in APA, 1.85\u00b10.87 mmol\/l in IHA), lower HDL cholesterol (1.25\u00b10.28 mmol\/l in APA, 1.06\u00b10.25 mmol\/l in IHA), higher PWV (7.91\u00b11.61 m\/s in APA, 8.99\u00b11.77 m\/s in IHA) and higher UAE (12.93\u00b12.21 mg\/l in APA, 28.09\u00b16.66 mg\/l in IHA). It seems that patients with IHA may have a slightly different phenotype compared to APA.<\/jats:p>","DOI":"10.33549\/physiolres.932335","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T08:11:11Z","timestamp":1587975071000},"page":"431-436","source":"Crossref","is-referenced-by-count":3,"title":["Have Main Types of Primary Aldosteronism Different Phenotype?"],"prefix":"10.33549","author":[{"given":"Z.","family":"\u0160OML\u00d3OV\u00c1","sequence":"first","affiliation":[{"name":"Third Department of Internal Medicine \u2013 Center for Hypertension, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"INDRA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"ROSA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"PETR\u00c1K","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"\u0160TRAUCH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"ZELINKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"HOLAJ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"JR.","given":"J.","family":"WIDIMSK\u00dd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2012,8,17]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ALBERTI KGMM, ECKEL RH, GRUNDY SM, ZIMMET PZ, CLEEMAN JI, DONATO KA, FRUCHART J-C, JAMES WPT, LORIA CM, SMITH SC JR: Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. 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