{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:53:36Z","timestamp":1767830016759,"version":"3.49.0"},"reference-count":59,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2014,2,28]]},"abstract":"<jats:p>We have previously shown that chronic renal failure in rats induces changes in motor activity and behavior. Similar work on the possible effects of acute renal failure (ARF) induced by cisplatin (CP) is lacking. This is the subject matter of the current work. CP was injected intraperitoneally (i.p.) at a single dose of 20 mg\/kg to induce a state of ARF, and three days later, its effects on motor activity, thermal and chemical nociceptive tests, neuromuscular coordination, pentobarbitone-sleeping time, exploration activity and two depression models were investigated. The platinum concentration in the kidneys and brains of mice was also measured. The occurrence of CP-induced ARF was ascertained by standard physiological, biochemical and histo-pathological methods. CP induced all the classical biochemical, physiological and histopathological signs of ARF. The average renal platinum concentration of CP-treated mice was 5.16 ppm, but there was no measurable concentration of platinum in the whole brains. CP treatment significantly decreased motor and exploration activities, and increased immobility time in depression models, suggesting a possible depression-like state. There was also a significant decrease in neuromuscular coordination in CP-treated mice. CP, given at a nephrotoxic dose, induced several adverse motor and behavioral alterations in mice. Further behavioral tests and molecular and biochemical investigations in the brains of mice with CP-induced ARF are warranted.<\/jats:p>","DOI":"10.33549\/physiolres.932585","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T19:49:02Z","timestamp":1600285742000},"page":"35-45","source":"Crossref","is-referenced-by-count":17,"title":["Motor and Behavioral Changes in Mice With Cisplatin-Induced Acute Renal Failure"],"prefix":"10.33549","author":[{"given":"B. H.","family":"ALI","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"RAMKUMAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. T.","family":"MADANAGOPAL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. I.","family":"WALY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"TAGELDIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"AL-ABRI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"FAHIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"YASIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"NEMMAR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2014,2,14]]},"reference":[{"key":"ref0","doi-asserted-by":"crossref","unstructured":"AKCAY A, TURKMEN K, LEE D, EDELSTEIN CL: Update on the diagnosis and management of acute kidney injury Int J Nephrol Renovasc Dis 3: 129-140, 2010.","DOI":"10.2147\/IJNRD.S8641"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"AL-KHARUSI N, BABIKER HA, AL-SALAM S, WALY MI, NEMMAR A, AL-LAWATI I, YASIN J, BEEGAM S, ALI BH: Ellagic acid protects against cisplatin-induced nephrotoxicity in rats: a dose-dependent study. Eur Rev Med Pharmacol Sci 17: 299-310, 2013.","DOI":"10.1111\/j.1472-8206.2011.01003.x"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"AL MOUNDHRI MS, AL-SALAM S, AL MAHROUQEE A, BEEGAM S, ALI BH: The effect of curcumin on oxaliplatin and Cisplatin neurotoxicity in rats: some behavioral, biochemical, and histopathological studies. J Med Toxicol 9: 25-33, 2013.","DOI":"10.1007\/s13181-012-0239-x"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"ALI BH, AL MOUNDHRI MS: Agents ameliorating or augmenting the nephrotoxicity of cisplatin and other platinum compounds: a review of some recent research. Food Chem Toxicol 44: 1173-1183, 2006.","DOI":"10.1016\/j.fct.2006.01.013"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"ALI BH, BASHIR AK, BANNA NR, TANIRA MO: Central nervous system activity of Rhazya stricta (Decne) in mice. Clin Exp Pharmacol Physiol 22: 248-253, 1995.","DOI":"10.1111\/j.1440-1681.1995.tb01989.x"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"ALI BH, BASHIR AK, TANIRA MO: The effect of Rhazya stricta Decne, a traditional medicinal plant, on spontaneous and drug-induced alterations in activity of rats. Pharmacol Biochem Behav 64: 455-460, 1999.","DOI":"10.1016\/s0091-3057(99)00099-4"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"ALI BH, AL-MOUNDHRI M, TAGELDIN M, AL HUSSEINI IS, MANSOUR MA, NEMMAR A, TANIRA MO: Ontogenic aspects of cisplatin-induced nephrotoxicity in rats. Food Chem Toxicol 46: 3355-3359, 2008.","DOI":"10.1016\/j.fct.2008.07.030"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"ALI BH, AL-SALAM S, AL HUSSENI I, KAYED RR, AL-MASROORI N, AL-HARTHI T, AL ZAABI M, NEMMAR A: Effects of Gum Arabic in rats with adenine-induced chronic renal failure. Exp Biol Med (Maywood) 235: 373-382, 2010.","DOI":"10.1258\/ebm.2009.009214"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"ALI BH, ZIADA A, AL HUSSENI I, BEEGAM S, NEMMAR A: Motor and behavioral changes in rats with adenine-induced chronic renal failure: influence of acacia gum treatment. Exp Biol Med (Maywood) 236: 107-112, 2011.","DOI":"10.1258\/ebm.2010.010163"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"ALTUN ZS, GUNES D, AKTAS S, ERBAYRAKTAR Z, OLGUN N: Protective effects of acetyl-L-carnitine on cisplatin cytotoxicity and oxidative stress in neuroblastoma. Neurochem Res 35: 437-443, 2010.","DOI":"10.1007\/s11064-009-0076-8"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"AMOS S, ADZU B, BINDA L, WAMBEBE C, GAMANIEL K: Neuropharmacological effect of the aqueous extract of Sphaeranthus senegalensis in mice. J Ethnopharmacol 78: 33-37, 2001.","DOI":"10.1016\/s0378-8741(01)00316-6"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"ANDREOLI SP: Acute kidney injury in children. Pediatr Nephrol 24: 253-263, 2009.","DOI":"10.1007\/s00467-008-1074-9"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"AZAMBUJA AA, LUNARDELLI A, NUNES FB, GASPARETO PB, DONADIO MV, DE FIGUEIREDO CE, DE OLIVEIRA JR: Effect of fructose-1,6-bisphosphate on the nephrotoxicity induced by cisplatin in rats. Inflammation 34: 67-71, 2011.","DOI":"10.1007\/s10753-010-9212-5"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"BALCOMBE JP: Laboratory environments and rodents' behavioural needs: a review. Lab Anim 40: 217-235, 2006.","DOI":"10.1258\/002367706777611488"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"BANJI D, BANJI OJ, ABBAGONI S, HAYATH MS, KAMBAM S, CHILUKA VL: Amelioration of behavioral aberrations and oxidative markers by green tea extract in valproate induced autism in animals. Brain Res 1410: 141-151, 2011.","DOI":"10.1016\/j.brainres.2011.06.063"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"BARBAS D, ZAPPULLA JP, ANGERS S, BOUVIER M, MOHAMED HA, BYRNE JH, CASTELLUCCI VF, DESGROSEILLERS L: An aplysia dopamine1-like receptor: molecular and functional characterization. J Neurochem 96: 414-427, 2006.","DOI":"10.1111\/j.1471-4159.2005.03561.x"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"BERNOCCHI G, BOTTONE MG, PICCOLINI VM, DAL BO V, SANTIN G, DE PASCALI SA, MIGONI D, FANIZZI FP: Developing central nervous system and vulnerability to platinum compounds. Chemother Res Pract 2011: 315418, 2011.","DOI":"10.1155\/2011\/315418"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"BROWN GR, NEMES C: The exploratory behaviour of rats in the hole-board apparatus: is head-dipping a valid measure of neophilia? Behav Processes 78: 442-448, 2008.","DOI":"10.1016\/j.beproc.2008.02.019"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"CASTAGNE V, MOSER P, ROUX S, PORSOLT RD: Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice. Curr Protoc Neurosci Chapter 8: Unit 8.10A, 2011.","DOI":"10.1002\/0471142301.ns0810as55"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"CATA JP, WENG HR, DOUGHERTY PM: Behavioral and electrophysiological studies in rats with cisplatin-induced chemoneuropathy. Brain Res 1230: 91-98, 2008.","DOI":"10.1016\/j.brainres.2008.07.022"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"CAVALETTI G, ALBERTI P, FRIGENI B, PIATTI M, SUSANI E: Chemotherapy-induced neuropathy. Curr Treat Options Neurol 13: 180-190, 2011.","DOI":"10.1007\/s11940-010-0108-3"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"CHIRINO YI, PEDRAZA-CHAVERRI J: Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity. Exp Toxicol Pathol 61: 223-242, 2009.","DOI":"10.1016\/j.etp.2008.09.003"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"COLLIER HO, DINNEEN LC, JOHNSON CA, SCHNEIDER C: The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother 32: 295-310, 1968.","DOI":"10.1111\/j.1476-5381.1968.tb00973.x"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"DE JONGE MJ, VERWEIJ J: Renal toxicities of chemotherapy. Semin Oncol 33: 68-73, 2006.","DOI":"10.1053\/j.seminoncol.2005.11.011"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"DOS SANTOS NA, CARVALHO RODRIGUES MA, MARTINS NM, DOS SANTOS AC: Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update. Arch Toxicol 86: 1233-1250, 2012.","DOI":"10.1007\/s00204-012-0821-7"},{"key":"ref25","unstructured":"EDDY NB, LEIMBACH D: Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. J Pharmacol Exp Ther 107: 385-393, 1953."},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"FILE SE: Effects of chlorpromazine on exploration and habituation in the rat. Br J Pharmacol 49: 303-310, 1973.","DOI":"10.1111\/j.1476-5381.1973.tb08376.x"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"FUJIMORI H: Potentiation of barbital hypnosis as an evaluation method for central nervous system depressants. Psychopharmacologia 7: 374-378, 1965.","DOI":"10.1007\/bf00403761"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"GERSNER R, GORDON-KIWKOWITZ M, ZANGEN A: Automated behavioral analysis of limbs' activity in the forced swim test. J Neurosci Methods 180: 82-86, 2009.","DOI":"10.1016\/j.jneumeth.2009.03.003"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"GULEC M, ORAL E, DURSUN OB, YUCEL A, HACIMUFTUOGLU A, AKCAY F, SULEYMAN H: Mirtazapine protects against cisplatin-induced oxidative stress and DNA damage in the rat brain. Psychiatry Clin Neurosci 67: 50-58, 2013.","DOI":"10.1111\/j.1440-1819.2012.02395.x"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"HEDAYATI SS, YALAMANCHILI V, FINKELSTEIN FO: A practical approach to the treatment of depression in patients with chronic kidney disease and end-stage renal disease. Kidney Int 81: 247-255, 2012.","DOI":"10.1038\/ki.2011.358"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"HOLMES PV: Rodent models of depression: reexamining validity without anthropomorphic inference. Crit Rev Neurobiol 15: 143-174, 2003.","DOI":"10.1615\/critrevneurobiol.v15.i2.30"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"IWATA K, WATANABE H, MORISAKI T, MATSUZAKI T, OHMURA T, HAMADA A, SAITO H: Involvement of indoxyl sulfate in renal and central nervous system toxicities during cisplatin-induced acute renal failure. Pharm Res 24: 662-671, 2007.","DOI":"10.1007\/s11095-006-9183-2"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"KANG KP, KIM DH, JUNG YJ, LEE AS, LEE S, LEE SY, JANG KY, SUNG MJ, PARK SK, KIM W: Alpha-lipoic acid attenuates cisplatin-induced acute kidney injury in mice by suppressing renal inflammation. Nephrol Dial Transplant 24: 3012-3020, 2009.","DOI":"10.1093\/ndt\/gfp242"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"KONG D, ZHUO L, GAO C, SHI S, WANG N, HUANG Z, LI W, HAO L: Erythropoietin protects against cisplatin-induced nephrotoxicity by attenuating endoplasmic reticulum stress-induced apoptosis. J Nephrol 26: 219-227, 2013.","DOI":"10.5301\/jn.5000177"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"LEE JS, KIM YT, JEON EK, WON HS, CHO YS, KO YH: Effect of green tea extracts on oxaliplatin-induced peripheral neuropathy in rats. BMC Complement Altern Med 12: 124, 2012.","DOI":"10.1186\/1472-6882-12-124"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"LEU L, BARIBEAULT D: A comparison of the rates of cisplatin (cDDP)--induced nephrotoxicity associated with sodium loading or sodium loading with forced diuresis as a preventative measure. J Oncol Pharm Pract 16: 167-171, 2010.","DOI":"10.1177\/1078155209346071"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"LI PK, BURDMANN EA, MEHTA RL: Acute kidney injury: global health alert. Transplantation 95: 653-657, 2013.","DOI":"10.1097\/tp.0b013e31828848bc"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"LI XB, SCHLUESENER HJ: Therapeutic effects of cisplatin on rat experimental autoimmune encephalomyelitis. Arch Immunol Ther Exp (Warsz) 54: 51-53, 2006.","DOI":"10.1007\/s00005-006-0005-3"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"MASUR J, MARTZ RM, CARLINI EA: Effects of acute and chronic administration of Cannabis sativa and (-) delta9-trans-tetrahydrocannabinol on the behavior of rats in an open-field arena. Psychopharmacologia 19: 388-397, 1971.","DOI":"10.1007\/bf00404383"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"MITAZAKI S, HASHIMOTO M, MATSUHASHI Y, HONMA S, SUTO M, KATO N, NAKAGAWASAI O, TAN-NO K, HIRAIWA K, YOSHIDA M, ABE S: Interleukin-6 modulates oxidative stress produced during the development of cisplatin nephrotoxicity. Life Sci 92: 694-700, 2013.","DOI":"10.1016\/j.lfs.2013.01.026"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"PABLA N, DONG Z: Curtailing side effects in chemotherapy: a tale of PKCdelta in cisplatin treatment. Oncotarget 3: 107-111, 2012.","DOI":"10.18632\/oncotarget.439"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"PABLA N, MURPHY RF, LIU K, DONG Z: The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. Am J Physiol 296: F505-F511, 2009.","DOI":"10.1152\/ajprenal.90545.2008"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"PARK HJ, STOKES JA, PIRIE E, SKAHEN J, SHTAERMAN Y, YAKSH TL: Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept. Anesth Analg 116: 224-231, 2013.","DOI":"10.1213\/ane.0b013e31826e1007"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"PEDERSEN AD, ROSSEN P, MEHLSEN MY, PEDERSEN CG, ZACHARIAE R, VON DER MAASE H: Long-term cognitive function following chemotherapy in patients with testicular cancer. J Int Neuropsychol Soc 15: 296-301, 2009.","DOI":"10.1017\/s1355617709090316"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"PEREZ RM, PEREZ JA, GARCIA LM, SOSSA H: Neuropharmacological activity of Solanum nigrum fruit. J Ethnopharmacol 62: 43-48, 1998.","DOI":"10.1016\/s0378-8741(98)00059-2"},{"key":"ref46","unstructured":"PORSOLT RD, BERTIN A, JALFRE M: Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229: 327-336, 1977."},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"SAAD SY, NAJJAR TA, AL-SOHAIBANI MO: The effect of rebamipide on cisplatin-induced nephrotoxicity in rats. Pharmacol Res 42: 81-86, 2000.","DOI":"10.1006\/phrs.2000.0662"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"SANCHEZ-GONZALEZ PD, LOPEZ-HERNANDEZ FJ, LOPEZ-NOVOA JM, MORALES AI: An integrative view of the pathophysiological events leading to cisplatin nephrotoxicity. Crit Rev Toxicol 41: 803-821, 2011.","DOI":"10.3109\/10408444.2011.602662"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"SENER MT, SENER E, TOK A, POLAT B, CINAR I, POLAT H, AKCAY F, SULEYMAN H: Biochemical and histologic study of lethal cisplatin nephrotoxicity prevention by mirtazapine. Pharmacol Rep 64: 594-602, 2012.","DOI":"10.1016\/s1734-1140(12)70855-1"},{"key":"ref50","unstructured":"SILVA AP, CERQUEIRA GS, NUNES LC, DE FREITAS RM: Effects of an aqueous extract of Orbignya phalerata Mart on locomotor activity and motor coordination in mice and as antioxidant in vitro. Pharmazie 67: 260-263, 2012."},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"SMOGORZEWSKI MJ: Central nervous dysfunction in uremia. Am J Kidney Dis 38: S122-S128, 2001.","DOI":"10.1053\/ajkd.2001.27419"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"STERU L, CHERMAT R, THIERRY B, SIMON P: The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl) 85: 367-370, 1985.","DOI":"10.1007\/bf00428203"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"VERA G, CHIARLONE A, MARTIN MI, ABALO R: Altered feeding behaviour induced by long-term cisplatin in rats. Auton Neurosci 126-127: 81-92, 2006.","DOI":"10.1016\/j.autneu.2006.02.011"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"VERVLIET B, RAES F: Criteria of validity in experimental psychopathology: application to models of anxiety and depression. Psychol Med 43: 2241-2244, 2013.","DOI":"10.1017\/s0033291712002267"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"WASEEM M, PARVEZ S: Mitochondrial dysfunction mediated cisplatin induced toxicity: modulatory role of curcumin. Food Chem Toxicol 53: 334-342, 2013.","DOI":"10.1016\/j.fct.2012.11.055"},{"key":"ref56","unstructured":"WILD KD, MCCORMICK J, BILSKY EJ, VANDERAH T, MCNUTT RW, CHANG KJ, PORRECA F: Antinociceptive actions of BW373U86 in the mouse. J Pharmacol Exp Ther 267: 858-865, 1993."},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"YAN HC, CAO X, DAS M, ZHU XH, GAO TM: Behavioral animal models of depression. Neurosci Bull 26: 327-337, 2010.","DOI":"10.1007\/s12264-010-0323-7"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"ZALAI D, SZEIFERT L, NOVAK M: Psychological distress and depression in patients with chronic kidney disease. Semin Dial 25: 428-438, 2012.","DOI":"10.1111\/j.1525-139x.2012.01100.x"}],"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T19:49:18Z","timestamp":1600285758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/63\/63_35.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,14]]},"references-count":59,"URL":"https:\/\/doi.org\/10.33549\/physiolres.932585","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2,14]]}}}