{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:25:26Z","timestamp":1778725526849,"version":"3.51.4"},"reference-count":35,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2014,8,31]]},"abstract":"<jats:p>The present study was devised to assess the effects of cadmium chloride (CdCl2) administration on certain andrological, endocrinological and biochemical alterations in adult male rabbits (n=24). The animals were assigned to control (n=8) and experimental (n=16) group. Experimental group was orally administered with 1.5 mg\/kg body weight of CdCl2. The trials were carried out for a total of 5 weeks and blood sampling was carried out on weekly basis. A gradual decrease was noticed for body weight in the experimental group from week 1 to 5, being significantly lower in week 4 and 5 (P&lt;0.05). A similar decremented trend was noticed for serum testosterone level being significantly lower in experimental group in week 4 and 5 (P&lt;0.001). Significantly lower values were noticed for prolactin in experimental group in week 4 and 5 (P&lt;0.05), than in the control. On the contrary, serum cortisol level showed a gradual increase in experimental group, from week 1 to 5, being significantly higher in week 4 and 5 (P&lt;0.05). Regarding the biochemical attributes, all the parameters under study revealed a gradually ascending trend. Statistical significance was, however, achieved in varying weeks and at varying levels. The total protein and albumin were significantly higher in week 4 and 5 (P&lt;0.01); alanine aminotransferase in week 2 (P&lt;0.01), 3 (P&lt;0.001), 4 (P&lt;0.01) and 5 (P&lt;0.001); aspartate aminotransferase in week 1, 2, 3, 4 and 5 (P&lt;0.01); and alkaline phosphatase in week 1, 2 (P&lt;0.01), 3, 4 and 5 (P&lt;0.0001), respectively. Overall mortality rate in experimental group was 68.75 (11\/16). In a nutshell, Cd exposure results in adverse effects on all physiological parameters of body and may lead to lethal consequences.<\/jats:p>","DOI":"10.33549\/physiolres.932641","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T13:56:45Z","timestamp":1604411805000},"page":"505-512","source":"Crossref","is-referenced-by-count":7,"title":["Cadmium Chloride Toxicity Revisited: Effect on Certain Andrological, Endocrinological and Biochemical Parameters of Adult Male Rabbits"],"prefix":"10.33549","author":[{"given":"S.","family":"SAJJAD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"MALIK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"FAROOQ","sequence":"additional","affiliation":[{"name":"University College of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"RASHID","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"NASIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"TARIQ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"REHMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2014,8,17]]},"reference":[{"key":"ref0","unstructured":"ABOU EL-NAGA EH, KHALID ME, MOHAMED AH: Toxicity of cadmium and copper and their effect on some biochemical parameters of marine fish. Egypt J Aquat Res 31: 60-71, 2005."},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"AMARA S, ABDELMELEK H, GARREL C, GUIRAUD P, DOUKI T, RAVANAT J, FAVIER A, SAKLY M, BEN RHOUMA K: Preventive effect of zinc against cadmium-induced oxidative stress in rat testis. J Reprod Dev 54: 129-134, 2008.","DOI":"10.1262\/jrd.18110"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"BISWAS NM, SENGUPTA R, CHATOPADHYAY GR, CHOUDHURY A, SARKAR M: Effect of ethanol on cadmium-induced testicular toxicity in male rats. Reprod Toxicol 15: 699-704, 2001.","DOI":"10.1016\/s0890-6238(01)00184-8"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"BURBURE C, BUCHET J, LEROYER A, NISSE C, HAGUENOER J, MUTTI A, SMERHOVSKY Z, CIKRT M, MALGORZATA T, RAZNEIWSKA G, JAKUBOWSKI M, BERNARD A: Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels. Environ Health Persp 114: 584-590, 2006.","DOI":"10.1289\/ehp.8202"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"CHOWHDURY MJ, MCDONALD DG, WOOD CM: Gastrointestinal uptake and fate of cadmium in rainbow trout acclimated to sublethal dietary cadmium. Aquat Toxicol 69: 149-163, 2004.","DOI":"10.1016\/j.aquatox.2004.05.002"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"DANG ZC, BERNTSSEN MHG, LUNDEBYE AK, FILK G, BONGA SEW, LOCK RAC: Metallothionein and cortisol receptor expression in gills of Atlantic salmon, Salmo salar, exposed to dietary cadmium. Aquat Toxicol 63: 91-101, 2001.","DOI":"10.1016\/s0166-445x(00)00168-5"},{"key":"ref6","unstructured":"EUROPEAN ENVIRONMENT AGENCY: European workshop on the impact of endocrine disruptors on human health and wildlife, 2-4 December 1996, Weybridge, UK. Report of the Proceedings. Report EU 17549. Copenhagen: European Commission DG VII."},{"key":"ref7","unstructured":"GHOSH N, BHATTACHARYA S: Thyrotoxicity of the chlorides of cadmium and mercury in rabbit. Bio Med Environ Sci 5: 236-240, 1992."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"GODT J, SCHEIDIG F, SIESTRUP CG, ESCHE V, BRANDENBERG P, REICH A, GRONEBERG DA: The toxicity of cadmium and insulting hazards for the human health. J Occ Toxicol 1: 22-26, 2006.","DOI":"10.1186\/1745-6673-1-22"},{"key":"ref9","unstructured":"GOVERNMENT OF PAKISTAN: Report on assessment of lead and cadmium in Pakistan. Ministry of Environment, Pakistan, 2006."},{"key":"ref10","unstructured":"HASSAN RA, AMIN DM, RAHMY NA, HATEM ME, DESSOUKY MI: Clinicopathological, histopathological and immunological studies on animals exposed to lead and cadmium under experimental conditions. New York Sci J 5: 120-136, 2012."},{"key":"ref11","unstructured":"HRISTEV H, PENKOV D, HALLAK AK, KIROVA M, BAYKOV B, BIZNAKOV A: Serum protein changes in rabbits after chronic administration of lead and cadmium. J Central Euro Agric 9: 157-162, 2007."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"HUSSAIN J, KHAN AL, REHMAN N, HAMAYUN N, SHAH T, NISAR M, BANO T, SHINWARI ZK, LEE I: Proximate and nutrient analysis of selected vegetable species: a case study of Karak region, Pakistan. Afr J Biotech 8: 2725-2729, 2009.","DOI":"10.3923\/pjn.2009.620.624"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"JARUP L, AKESSON A: Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 238: 201-208, 2009.","DOI":"10.1016\/j.taap.2009.04.020"},{"key":"ref14","unstructured":"JABEEN F, CHAUDHRY AS: Effects of sodium selenite in cadmium chloride induced \thepatoxicity in male Sprague-Dawley rats. Pak J Zool 43: 957-965, 2011."},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"KHAN S, AHMAD I, SHAH MT, REHMAN S, KHALIQ A: Use of constructed wetland for the removal of heavy metals from industrial wastewater. J Environ Manage 90: 3451-3457, 2009.","DOI":"10.1016\/j.jenvman.2009.05.026"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"KOWALCZYK E, KOPFF A, FIJALKOWSKI P, KOPFF M, NIEDWOROK J, BLASZCYZK J, KEDZIORA J, TYSLEROWICZ P: Effect of anthocyanins on selected biochemical parameters in rats exposed to cadmium. Acta Biochim Pol 50: 543-548, 2003.","DOI":"10.18388\/abp.2003_3707"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"LAFUENTE A, ESQUIFINO AI: Cadmium effects on hypothalamic activity and pituitary hormone secretion in the male. Toxicol Lett 110: 209-218, 2000.","DOI":"10.1016\/s0378-4274(99)00159-9"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"LAFUENTE A, MARQUEZ N, PEREZ-LORENZO M, PAZO D, ESQUIFINO AI: Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic-pituitary-testicular axis function in the rat. Food Chem Toxicol 38: 913-923, 2000.","DOI":"10.1016\/s0278-6915(00)00077-6"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"LAFUENTE A, CANO P, ESQUIFINO A: Are cadmium effects on plasma gonadotropins, prolactin, ACTH, GH and TSH levels, dose-dependent? Biometals 16: 243-250, 2003.","DOI":"10.1023\/A:1020658128413"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"LANGE IG, DAXENBERGER A, SCHIFFER B, WITTERS H, IBARRETA D, MEYER HHD: Sex hormones originating from different livestock production systems: fate and potential disrupting activity in the environment. Anal Chim Acta 473: 27-37, 2002a.","DOI":"10.1016\/s0003-2670(02)00748-1"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"LANGE A, AUSSEIL O, SEGNER H: Alterations of tissue glutathione levels and metallothionein mRNA in rainbow trout during single and combined exposure to cadmium and zinc. Comp Biochem Phys C 131: 231-243, 2002b.","DOI":"10.1016\/s1532-0456(02)00010-8"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"MAFFINNI MV, RUBIN BS, SONNENSCHEIN C, SOTO AM: Endocrine disruptors and reproductive health: the case of bisphenol-A. Mol Cell Endocrinol 254-255: 179-186, 2006.","DOI":"10.1016\/j.mce.2006.04.033"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"MEYER KJ, REIF JS, VEERAMACHANENI DNR, LUBEN TJ, MOSLEY BS, NUCKOLS JR: Agricultural pesticide use and hypospadias in eastern Arkansas. Environ Health Persp 114: 1589-1595, 2006.","DOI":"10.1289\/ehp.9146"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"RONCHETTI SA, MILER EA, DUVILANSKI BH, CABILLA JP: Cadmium mimics estrogen-driven cell proliferation and prolactin secretion from anterior pituitary cells. Plos One 8: 1-13, 2013.","DOI":"10.1371\/journal.pone.0081101"},{"key":"ref25","unstructured":"SAFE SH, FOSTER WG, LAMB JC, NEWBOLD RR, VAN DER KRAAK G: Estrogenicity and endocrine disruption. Report No.: 16. Iowa: Council for Agricultural Science and Technology, 2000."},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"SANT\u2019ANA MG, MORAES R, BERNARDI MM: Toxicity of cadmium in Japanese quail: evaluation of body weight, renal function and cellular immune response. Environ Res 99: 273-277, 2005.","DOI":"10.1016\/j.envres.2005.06.003"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"SATARUG S, NISHIJO M, UJJIN P, VANAVANITKUN Y, MOORE MR: Cadmium-induced nephropathy in the development of high blood pressure. Toxicol Lett 157: 57-68, 2005.","DOI":"10.1016\/j.toxlet.2005.01.004"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"SIU ER, MRUK DD, PORTO CS, CHANG CY: Cadmium-induced testicular injury. Toxicol Appl Pharm 28: 240-249, 2009.","DOI":"10.1016\/j.taap.2009.01.028"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"STOTHS SJ, BAGCHI D, HASSOUN E, BAGCHI M: Oxidative mechanisms in the toxicity of chromium and cadmium ions. J Environ Pathol Toxicol Oncol 20: 77-82, 2001.","DOI":"10.1615\/jenvironpatholtoxicoloncol.v20.i2.10"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"VALKO M, MORRIS H, CRONIN MTD: Metals, toxicity and oxidative stress. Curr Med Chem 12: 1161-1208, 2005.","DOI":"10.2174\/0929867053764635"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"WU SM, SHIH MJ, HO YC: Toxicological stress response and cadmium distribution in hybrid tilapia (Oreochromis sp.) upon cadmium exposure. Comp Biochem Physiol C 145: \t218-226, 2007.","DOI":"10.1016\/j.cbpc.2006.12.003"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"YIN S, SHEU J, LIN T: Lipid peroxidation in rat adrenal glands after administration cadmium and role of essential metals. J Toxicol Env Heal A 62: 47-56, 2000.","DOI":"10.1080\/00984100050201668"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"ZALUPS RK, AHMAD S: Molecular handling of cadmium in transporting epithelia. Toxicol Appl Pharmacol 186: 163-188, 2003.","DOI":"10.1016\/S0041-008X(02)00021-2"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"ZENG X, JIN T, ZHOU Y, NORDBERG GF: Changes of serum sex hormone levels and MT mRNA expression in rats orally exposed to cadmium. J Toxicol 186: 109-118, 2003.","DOI":"10.1016\/s0300-483x(02)00725-4"}],"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T13:57:24Z","timestamp":1604411844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/63\/63_505.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,17]]},"references-count":35,"URL":"https:\/\/doi.org\/10.33549\/physiolres.932641","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8,17]]}}}