{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T05:26:43Z","timestamp":1773466003346,"version":"3.50.1"},"reference-count":31,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2016,4,29]]},"abstract":"<jats:p>Chronic constriction injury to the sciatic nerve was used as an animal model of neuropathic pain. Instead of frequently used reflex-based tests we used an operant thermal place preference test to evaluate signs of neuropathic pain and the effect of baclofen administration in rats with neuropathy. Chronic constriction injury was induced by four loose ligations of the sciatic nerve. Thermal place preference (45 \u00b0C vs. 22 \u00b0C and 45 \u00b0C vs. 11 \u00b0C) was measured after the ligation and after the administration of baclofen in sham and experimental rats. Rats with the chronic constriction injury spent significantly less time on the colder plate compared to sham operated animals at the combination 45 \u00b0C vs. 11 \u00b0C. After administration of baclofen (10 mg\/kg s.c.), the aversion to the colder plate in rats with chronic constriction injury disappeared. At the combination 45 \u00b0C vs. 22 \u00b0C, no difference in time spent on colder and\/or warmer plate was found between sham and experimental animals. These findings show the importance of cold allodynia evaluation in rats with chronic constriction injury and the effectiveness of baclofen in this neuropathic pain model.<\/jats:p>","DOI":"10.33549\/physiolres.933008","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T11:50:56Z","timestamp":1581594656000},"page":"349-355","source":"Crossref","is-referenced-by-count":10,"title":["Baclofen Reversed Thermal Place Preference in Rats With Chronic Constriction Injury"],"prefix":"10.33549","author":[{"given":"K.","family":"SALTE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"LEA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"FRANEK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"VACULIN","sequence":"additional","affiliation":[{"name":"Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2016,4,15]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"BALIKI M, CALVO O, CHIALVO DR, APKARIAN AV: Spared nerve injury rats exhibit thermal hyperalgesia on an automated operant dynamic thermal escape task. 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