{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:04:45Z","timestamp":1781712285716,"version":"3.54.5"},"reference-count":52,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2015,10,29]]},"abstract":"<jats:p>Cytokines are widely known mediators of inflammation accompanying many neurodegenerative disorders including normal pressure hydrocephalus (NPH). NPH is caused by impaired cerebrospinal fluid (CSF) reabsorption and treated by surgical shunt insertion. The diagnostics is still complicated and the shunt effect is not durable; after several years, dementia may develop. In the clinical practice, biomarkers support the diagnostics as well as the further time course of many neurodegenerative diseases. Until recently, no reliable biomarker for NPH was evaluated. The attempt of this review was to make a survey concerning cytokines as possible NPH markers. Among all reviewed cytokines, the most promising are CSF IL-10 and IL-33, enabling to follow-up the disease progression and monitoring the effectiveness of the shunt insertion.<\/jats:p>","DOI":"10.33549\/physiolres.933069","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T12:55:36Z","timestamp":1587473736000},"page":"S283-S290","source":"Crossref","is-referenced-by-count":19,"title":["The Impact of Selected Cytokines in the Follow-Up of Normal Pressure Hydrocephalus"],"prefix":"10.33549","author":[{"given":"L.","family":"SOSVOROVA","sequence":"first","affiliation":[{"name":"Department of Steroids and Proteofactors, Institute of Endocrinology, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"MOHAPL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"VCELAK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"HILL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"VITKU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"HAMPL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2015,10,14]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ADAMS R, FISHER C, HAKIM S, OJEMANN R, SWEET W: Symptomatic occult hydrocephalus with normal cerebrospinal-fluid pressure: a treatable syndrome. New Engl J Med 273: 117-126, 1965.","DOI":"10.1056\/nejm196507152730301"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"BLUM-DEGENA D, M\u00dcLLER T, KUHN W, GERLACH M, PRZUNTEK H, RIEDERER P: Interleukin-1\u03b2 and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci Lett 202: 17-20, 1995.","DOI":"10.1016\/0304-3940(95)12192-7"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"BREAN A, FREDO HL, SOLLID S, MULLER T, SUNDSTROM T, EIDE PK: Five-year incidence of surgery for idiopathic normal pressure hydrocephalus in Norway. Acta Neurol Scand 120: 314-316, 2009.","DOI":"10.1111\/j.1600-0404.2009.01250.x"},{"key":"ref3","unstructured":"CACABELOS R, BARQUERO M, GARCIA P, ALVAREZ X, VARELA DSE: Cerebrospinal fluid interleukin-1 beta (IL-1 beta) in Alzheimer's disease and neurological disorders. Method Find Exp Clin 13: 455-458, 1991."},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"CHAKRABORTY S, KAUSHIK DK, GUPTA M, BASU A: Inflammasome signaling at the heart of central nervous system pathology. J Neurosci Res 88: 1615-1631, 2010.","DOI":"10.1002\/jnr.22343"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"CUNNINGHAM C, CAMPION S, LUNNON K, MURRAY CL, WOODS JF, DEACON RM, RAWLINS JNP, PERRY VH: Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biol Psychiat 65: 304-312, 2009.","DOI":"10.1016\/j.biopsych.2008.07.024"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"DINARELLO CA, THOMPSON RC: Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol Today 12: 404-410, 1991.","DOI":"10.1016\/0167-5699(91)90142-g"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"GADANI SP, CRONK JC, NORRIS GT, KIPNIS J: IL-4 in the brain: a cytokine to remember. J Immunol 189: 4213-4219, 2012.","DOI":"10.4049\/jimmunol.1202246"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"HAMPL R, BICIKOVA M, SOSVOROVA L: Hormones and the blood-brain barrier. Horm Mol Biol Clin Investig 21: 159-164, 2015.","DOI":"10.1515\/hmbci-2014-0042"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"HART PH, VITTI GF, BURGESS DR, WHITTY GA, PICCOLI DS, HAMILTON JA: Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2. Proc Natl Acad Sci USA 86: 3803-3807, 1989.","DOI":"10.1073\/pnas.86.10.3803"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"ISEKI C, KAWANAMI T, NAGASAWA H, WADA M, KOYAMA S, KIKUCHI K, ARAWAKA S, KURITA K, DAIMON M, MORI E, KATO T: Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM) in the elderly: a prospective study in a Japanese population. J Neurol Sci 277: 54-57, 2009.","DOI":"10.1016\/j.jns.2008.10.004"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"ISHIGAME H, KAKUTA S, NAGAI T, KADOKI M, NAMBU A, KOMIYAMA Y, FUJIKADO N, TANAHASHI Y, AKITSU A, KOTAKI H, SUDO K, NAKAE S, SASAKAWA C, IWAKURA Y: Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30: 108-119, 2009.","DOI":"10.1016\/j.immuni.2008.11.009"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"ISHIZU T, OSOEGAWA M, MEI FJ, KIKUCHI H, TANAKA M, TAKAKURA Y, MINOHARA M, MURAI H, MIHARA F, TANIWAKI T, KIRA J: Intrathecal activation of the IL-17\/IL-8 axis in opticospinal multiple sclerosis. Brain 128: 988-1002, 2005.","DOI":"10.1093\/brain\/awh453"},{"key":"ref13","unstructured":"JANEWAY C, TRAVERS P, WALPORT M, SHLOMCHIK M: An introduction to immunobiology and innate imunity. In: Immunobiology. 6th edition. LAWRENCE E (ed.), Garland Science, New York, 2004, pp 1-100."},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"JARAJ D, RABIEI K, MARLOW T, JENSEN C, SKOOG I, WIKKELSO C: Prevalence of idiopathic normal-pressure hydrocephalus. Neurology 82: 1449-1454, 2014.","DOI":"10.1212\/wnl.0000000000000342"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"JIN W, DONG C: IL-17 cytokines in immunity and inflammation. Emerg Microbes Infect 2: e60, 2013.","DOI":"10.1038\/emi.2013.58"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"JOVANOVIC DV, DI BATTISTA JA, MARTEL-PELLETIER J, JOLICOEUR FC, HE Y, ZHANG M, MINEAU F, PELLETIER J-P: IL-17 stimulates the production and expression of proinflammatory cytokines, IL-\u03b2 and TNF-\u03b1, by human macrophages. J Immunol 160: 3513-3521, 1998.","DOI":"10.4049\/jimmunol.160.7.3513"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"KAZUI H, MORI E, OHKAWA S, OKADA T, KONDO T, SAKAKIBARA R, UEKI O, NISHIO Y, ISHII K, KAWAGUCHI T, ISHIKAWA M, TAKEDA M: Predictors of the disappearance of triad symptoms in patients with idiopathic normal pressure hydrocephalus after shunt surgery. J Neurol Sci 328: 64-69, 2013.","DOI":"10.1016\/j.jns.2013.02.020"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"KILLER M, ARTHUR A, AL-SCHAMERI AR, BARR J, ELBERT D, LADURNER G, SHUM J, CRUISE G: Cytokine and growth factor concentration in cerebrospinal fluid from patients with hydrocephalus following endovascular embolization of unruptured aneurysms in comparison with other types of hydrocephalus. Neurochem Res 35: 1652-1658, 2010.","DOI":"10.1007\/s11064-010-0226-z"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"KISHIMOTO T, AKIRA S, TAGA T: Interleukin-6 and its receptor: a paradigm for cytokines. Science 258: 593-597, 1992.","DOI":"10.1126\/science.1411569"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"KITAZAWA K, TADA T: Elevation of transforming growth factor-beta 1 level in cerebrospinal fluid of patients with communicating hydrocephalus after subarachnoid hemorrhage. Stroke 25: 1400-1404, 1994.","DOI":"10.1161\/01.str.25.7.1400"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"KOIVISTO AM, ALAFUZOFF I, SAVOLAINEN S, SUTELA A, RUMMUKAINEN J, KURKI M, J\u00c4\u00c4SKEL\u00c4INEN JE, SOININEN H, RINNE J, LEINONEN V: Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus. Neurosurgery 72: 1-8, 2013.","DOI":"10.1227\/neu.0b013e31827414b3"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"KRAKAUER T: IL-10 inhibits the adhesion of leukocytic cells to IL-1-activated human endothelial cells. Immunol Lett 45: 61-65, 1995.","DOI":"10.1016\/0165-2478(94)00226-h"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"LEINONEN V, MENON LG, CARROLL RS, DELLO IACONO D, GREVET J, JAASKELAINEN JE, BLACK PM: Cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus. Int J Alzheimers Dis 2011: 1-6, 2011.","DOI":"10.4061\/2011\/312526"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"LI X, MIYAJIMA M, JIANG C, ARAI H: Expression of TGF-betas and TGF-beta type II receptor in cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus. Neurosci Lett 413: 141-144, 2007.","DOI":"10.1016\/j.neulet.2006.11.039"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"LIEW FY, PITMAN NI, MCINNES IB: Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat Rev Immunol 10: 103-110, 2010.","DOI":"10.1038\/nri2692"},{"key":"ref26","unstructured":"LOSSINSKY A, SHIVERS R: Structural pathways for macromolecular and cellular transport across the blood-brain barrier during inflammatory conditions. Review. Histol Histopathol 19: 535-564, 2004."},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"MATHIESEN T, ANDERSSON B, LOFTENIUS A, VON HOLST H: Increased interleukin-6 levels in cerebrospinal fluid following subarachnoid hemorrhage. J Neurosurg 78: 562-567, 1993.","DOI":"10.3171\/jns.1993.78.4.0562"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"MOGI M, HARADA M, NARABAYASHI H, INAGAKI H, MINAMI M, NAGATSU T: Interleukin (IL)-1\u03b2, IL-2, IL-4, IL-6 and transforming growth factor-\u03b1 levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease. Neurosci Lett 211: 13-16, 1996.","DOI":"10.1016\/0304-3940(96)12706-3"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"PARK H, LI Z, YANG XO, CHANG SH, NURIEVA R, WANG Y-H, WANG Y, HOOD L, ZHU Z, TIAN Q: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6: 1133-1141, 2005.","DOI":"10.1038\/ni1261"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"PARK KW, LEE HG, JIN BK, LEE YB: Interleukin-10 endogenously expressed in microglia prevents lipopolysaccharide-induced neurodegeneration in the rat cerebral cortex in vivo. Exp Mol Med 39: 812-819, 2007.","DOI":"10.1038\/emm.2007.88"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"PYYKKO OT, LUMELA M, RUMMUKAINEN J, NERG O, SEPPALA TT, HERUKKA SK, KOIVISTO AM, ALAFUZOFF I, PULI L, SAVOLAINEN S, SOININEN H, JAASKELAINEN JE, HILTUNEN M, ZETTERBERG H, LEINONEN V: Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus. PloS One 9: e91974, 2014.","DOI":"10.1371\/journal.pone.0091974"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"QIAN L, HONG J-S, FLOOD P: Role of microglia in inflammation-mediated degeneration of dopaminergic neurons: neuroprotective effect of interleukin 10. J Neural Transm 70 (Suppl): 367-371, 2006.","DOI":"10.1007\/978-3-211-45295-0_56"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"REDDY GK, BOLLAM P, CALDITO G: Long-term outcomes of ventriculoperitoneal shunt surgery in patients with hydrocephalus. World Neurosurg 81: 404-410, 2014.","DOI":"10.1016\/j.wneu.2013.01.096"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"RELKIN N, MARMAROU A, KLINGE P, BERGSNEIDER M, BLACK PM: Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery 57: 4-16, 2005.","DOI":"10.1227\/01.neu.0000168185.29659.c5"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"REMARQUE EJ, BOLLEN EL, WEVERLING-RIJNSBURGER AWE, LATERVEER JC, BLAUW GJ, WESTENDORP RGJ: Patients with Alzheimer's disease display a pro-inflammatory phenotype. Exp Gerontol 36: 171-176, 2001.","DOI":"10.1016\/s0531-5565(00)00176-5"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"RIGAMONTI D: Adult Hydrocephalus. Cambridge University Press, New York, 2014.","DOI":"10.1017\/CBO9781139382816"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"ROTA E, BELLONE G, ROCCA P, BERGAMASCO B, EMANUELLI G, FERRERO P: Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients. Neurol Sci 27: 33-39, 2006.","DOI":"10.1007\/s10072-006-0562-6"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"ROTHWELL N: Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential. Brain Behav Immun 17: 152-157, 2003.","DOI":"10.1016\/S0889-1591(02)00098-3"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"ROTHWELL NJ, LUHESHI GN: Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci 23: 618-625, 2000.","DOI":"10.1016\/s0166-2236(00)01661-1"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"RUBIO-PEREZ JM, MORILLAS-RUIZ JM: A review: inflammatory process in Alzheimer's disease, role of cytokines. TheScientificWorldJournal 2012: 756357, 2012.","DOI":"10.1100\/2012\/756357"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"SASAYAMA D, HATTORI K, WAKABAYASHI C, TERAISHI T, HORI H, OTA M, YOSHIDA S, ARIMA K, HIGUCHI T, AMANO N, KUNUGI H: Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder. J Psychiatr Res 47: 401-406, 2013.","DOI":"10.1016\/j.jpsychires.2012.12.001"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"SAWADA M, SUZUMURA A, HOSOYA H, MARUNOUCHI T, NAGATSU T: Interleukin\u201010 inhibits both production of cytokines and expression of cytokine receptors in microglia. J Neurochem 72: 1466-1471, 1999.","DOI":"10.1046\/j.1471-4159.1999.721466.x"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"SCHMITZ J, OWYANG A, OLDHAM E, SONG Y, MURPHY E, MCCLANAHAN TK, ZURAWSKI G, MOSHREFI M, QIN J, LI X: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23: 479-490, 2005.","DOI":"10.1016\/j.immuni.2005.09.015"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"SEPPI D, PUTHENPARAMPIL M, FEDERLE L, RUGGERO S, TOFFANIN E, RINALDI F, PERINI P, GALLO P: Cerebrospinal fluid IL-1\u03b2 correlates with cortical pathology load in multiple sclerosis at clinical onset. J Neuroimmunol 270: 56-60, 2014.","DOI":"10.1016\/j.jneuroim.2014.02.014"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"SIMI A, TSAKIRI N, WANG P, ROTHWELL NJ: Interleukin-1 and inflammatory neurodegeneration. Biochem Soc Trans 35: 1122-1126, 2007.","DOI":"10.1042\/bst0351122"},{"key":"ref46","unstructured":"SOSVOROVA L, VCELAK J, MOHAPL M, VITKU J, BICIKOVA M, HAMPL R: Selected pro- and anti-inflammatory cytokines in cerebrospinal fluid in normal pressure hydrocephalus. Neuro Endocrinol Lett 35: 586-593, 2014."},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"TARKOWSKI E, TULLBERG M, FREDMAN P, WIKKELSO C: Normal pressure hydrocephalus triggers intrathecal production of TNF-alpha. Neurobiol Aging 24: 707-714, 2003.","DOI":"10.1016\/s0197-4580(02)00187-2"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"TARNARIS A, WATKINS LD, KITCHEN ND: Biomarkers in chronic adult hydrocephalus. Cerebrospinal Fluid Res 3: 11, 2006.","DOI":"10.1186\/1743-8454-3-11"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"WITOWSKI J, KSIAZEK K, JORRES A: Interleukin-17: a mediator of inflammatory responses. Cell Mol Life Sci 61: 567-579, 2004.","DOI":"10.1007\/s00018-003-3228-z"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"WYSS-CORAY T, MUCKE L: Inflammation in neurodegenerative disease - a double-edged sword. Neuron 35: 419-432, 2002.","DOI":"10.1016\/s0896-6273(02)00794-8"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"YAMAMOTO D, KAZUI H, WADA T, NOMURA K, SUGIYAMA H, SHIMIZU Y, YOSHIYAMA K, YOSHIDA T, KISHIMA H, YAMASHITA F, YOSHIMINE T, TAKEDA M: Association between milder brain deformation before a shunt operation and improvement in cognition and gait in idiopathic normal pressure hydrocephalus. 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