{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:51:42Z","timestamp":1769907102475,"version":"3.49.0"},"reference-count":34,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2015,10,29]]},"abstract":"<jats:p>In this review we summarize recent opinions on the possible role of vitamin D in the risk of thyroid diseases development. It may be concluded from the available data that vitamin D deficiency, particularly levels below 12.5 ng\/ml should be considered as an additional, but important risk factor for development of thyroid autoimmunity, both chronic autoimmune thyroiditis and Graves\u00b4 disease. A higher risk of Graves\u00b4 disease development is also associated with several polymorphisms in the gene encoding for vitamin D binding protein and for the specific receptor of active form of vitamin D \u2013 1,25-(OH)2D3 in the respective target cells. Important for development of thyroid cancer appeared polymorphisms of genes encoding for vitamin D receptors and of genes encoding for the participating hydroxylating enzymes in thyroid tissue, leading to a diminished local 1,25-(OH)2D3 formation capacity with following alteration of antiproliferatory, antiapoptotic and prodifferentiating efficacy of the latter. Whether supplementation with high doses of vitamin D or its analogues possesses preventive or therapeutic effect is an object of intensive studies.<\/jats:p>","DOI":"10.33549\/physiolres.933083","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T12:54:17Z","timestamp":1587473657000},"page":"S95-S100","source":"Crossref","is-referenced-by-count":24,"title":["Vitamin D and Thyroid Diseases"],"prefix":"10.33549","author":[{"given":"K.","family":"VONDRA","sequence":"first","affiliation":[{"name":"Institute of Endocrinology, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"ST\u00c1RKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"HAMPL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2015,10,14]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ABD EL GAWAD SS, ABDUL SAMEE ER, METWALI AA, ABD EL GAWAD MS: Vitamin D receptor gene polymorphism and its association with 1,25-dihydroxyvitamin D in patients with Graves disease in an Egyptian population: a pilot study. 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