{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:33:42Z","timestamp":1792020822283,"version":"4.4.0"},"reference-count":55,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2015,12,30]]},"abstract":"<jats:p>Diabetes mellitus (DM) has been known for many years to be associated with poor cardiovascular prognosis. Due to the sensitive neuropathy, the coronary artery disease in diabetic patients is frequently asymptomatic. Also twelve leads resting ECG can be within normal limits even in an advanced stage of coronary artery disease. Therefore in addition to the standard ECG other electrocardiographic procedures started to be studied in order to find some typical signs of myocardial damages caused by DM. Repeatedly reported results showed in DM patients without cardiovascular complications the tachycardia, shortening of the QRS and QT intervals, increase of the dispersion of QT interval, decreased amplitudes of depolarization waves, shortened activation time of ventricular myocardium and a flattening of T waves confirmed by the lower value of maximum and minimum in repolarization body surface isopotential maps. Most of these changes are even more pronounced in patients with cardiac autonomic neuropathy. Comparison with similar ECG changes in other diseases suggests that the electrocardiographic changes in DM patients are not specific and that they are particularly caused by an increased tone of the sympathetic nervous system what was indirectly confirmed by the heart rate variability findings in these patients.<\/jats:p>","DOI":"10.33549\/physiolres.933230","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T08:25:06Z","timestamp":1586939106000},"page":"S559-S566","source":"Crossref","is-referenced-by-count":30,"title":["Electrocardiographic Changes in Diabetes Mellitus"],"prefix":"10.33549","author":[{"given":"O.","family":"KITTNAR","sequence":"first","affiliation":[{"name":"Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2015,12,14]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ADEBAYO RA, IKWU AN, BALOGUN MO, AKINTOMIDE AO, MENE-AFEJUKU TO, ADEYEYE VO, BAMIKOLE OJ, BISIRIYU LA, AJAYI OE, OGUNYEMI SA, OKETONA OA: Evaluation of the indications and arrhythmic patterns of 24 hour Holter electrocardiography among hypertensive and diabetic patients seen at OAUTHC, Ile-Ife Nigeria. 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Int J Clin Pract Suppl 129: 27-32, 2002."},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"HIGHAM PD, CAMPBELL RWF: QT dispersion. Br Heart J 71: 508-510, 1994.","DOI":"10.1136\/hrt.71.6.508"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"JAVORKA M, JAVORKOVA J, TONHAJZEROVA I, JAVORKA K: Parasympathetic versus sympathetic control of the cardiovascular system in young patients with type 1 diabetes mellitus. Clin Physiol Funct Imaging 25: 270-274, 2005.","DOI":"10.1111\/j.1475-097x.2005.00623.x"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"KANNEL WB, NEATON JD, WENWORTH D, THOMAS HE, STAMLER J, HULLEY SB, KJELSBERG MO: Overall and coronary heart disease mortality rates in relation to major risk factors in 325 348 men screened for the MRFIT. Multiple Risk Factor Intervention Trial. 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Physiol Res 59: 203-209, 2010.","DOI":"10.33549\/physiolres.931715"},{"key":"ref40","unstructured":"PICKUP JC, WILLIAMS G: Handbook of Diabetes. Blackwell Publishing, Oxford, 2003."},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"PISVEJCOVA K, PACLT I, SLAVICEK J, KITTNAR O, DOHNALOVA A, KITZLEROV\u00c1 E: Electrocardiogram, vectocardiogram and body surface maps in patients with panic disorder. Physiol Res 51: 401-406, 2002.","DOI":"10.1016\/s0924-9338(00)94672-8"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"POYHONEN-ALHO M, VIITASALO M, NICHOLLS MG, LINDSTROM BM, VAANANEN H, KAAJA R: Imbalance of the autonomic nervous system at night in women with gestational diabetes. 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Curr Diab Rep 12: 43-52, 2012.","DOI":"10.1007\/s11892-011-0238-3"},{"key":"ref47","unstructured":"VALOUCH P, SLAV\u00cd\u010cEK J, TICH\u00dd JA, PETERKA Z, KITTNAR O, TROJAN S, TREFN\u00dd Z, NOV\u00c1K V: Electrocardiographic body surface maps (BSM) in patients with ischemic heart disease examined by coronary angiography. Prague Medical Report (Sborn L\u00e9k) 105: 131-140, 2004."},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"VAN DE LOO A, ARENDTS W, HOHNLOSER SH: Variability of QT dispersion measurements in the surface electrocardiogram in patients with acute myocardial infarction and in normal subjects. Am J Cardiol 74: 1113-1118, 1994.","DOI":"10.1016\/0002-9149(94)90462-6"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"VINIK AI, ZIEGLER D: Diabetic cardiovascular autonomic neuropathy. 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