{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:43:35Z","timestamp":1774323815587,"version":"3.50.1"},"reference-count":44,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2017,4,30]]},"abstract":"<jats:p>Accumulating evidence indicates that hypertension is associated with \u201cion channel remodeling\u201d of vascular smooth muscle cells (VSMCs). The objective of this study was to determine the effects of exercise intensity\/volume on hypertension-associated changes in large-conductance Ca2+-activated K+ (BKCa) channels in mesenteric arteries (MAs) from spontaneously hypertensive rats (SHR). Male SHRs were randomly assigned to three groups: a low-intensity aerobic exercise group (SHR-L: 14 m\/min), a moderate-intensity aerobic exercise group (SHR-M: 20 m\/min), and a sedentary group (SHR). Age-matched Wistar-Kyoto rats (WKYs) were used as normotensive controls. Exercise groups completed an 8-week exercise program. Elevation of the \u03b1 and \u03b21 proteins was unequal in MA myocytes from SHRs, with the \u03b21 subunit increasing more than the \u03b1 subunit. BKCa contribution to vascular tone regulation was higher in the myocytes and arteries of SHRs compared to WKYs. SHR BKCa channel subunit protein expression, \u03b21\/\u03b1 ratio, whole cell current density and single-channel open probability was also increased compared with WKYs. Aerobic exercise lowered systemic blood pressure and normalized hypertension-associated BKCa alterations to normotensive control levels in the SHRs. These effects were more pronounced in the moderate-intensity group than in the low-intensity group. There is a dose-effect for aerobic exercise training in the range of low to moderate-intensity and accompanying volume for the correction of the pathological adaptation of BKCa channels in myocytes of MAs from SHR.<\/jats:p>","DOI":"10.33549\/physiolres.933407","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T11:32:08Z","timestamp":1576841528000},"page":"219-233","source":"Crossref","is-referenced-by-count":9,"title":["Aerobic Exercise of Low to Moderate Intensity Corrects Unequal Changes in BKCa Subunit Expression in the Mesenteric Arteries of Spontaneously Hypertensive Rats"],"prefix":"10.33549","author":[{"given":"Y.","family":"ZHANG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"CHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"LU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"SHI","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Beijing Sport University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2017,4,16]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"AGARWAL D, WELSCH MA, KELLER JN, FRANCIS J: Chronic exercise modulates RAS components and improves balance between pro-and anti-inflammatory cytokines in the brain of SHR. 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