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In superior mesenteric artery isolated from normotensive Wistar-Kyoto rats (WKY), PVAT exhibited inhibitory influence on the contractions to exogenous noradrenaline as well as to endogenous noradrenaline released from arterial sympathetic nerves during transmural electrical stimulation or after application of tyramine. In contrast, the abdominal aorta with intact PVAT responded with larger contractions to transmural electrical stimulation and tyramine when compared to the aorta after removing PVAT; the responses to noradrenaline were similar in both. This indicates that PVAT may contain additional sources of endogenous noradrenaline which could be responsible for the main difference in the modulatory effect of PVAT on adrenergic contractions between abdominal aortas and superior mesenteric arteries. In spontaneously hypertensive rats (SHR), the anticontractile effect of PVAT in mesenteric arteries was reduced, and the removal of PVAT completely eliminated the difference in the dose-response curves to exogenous noradrenaline between SHR and WKY. These results suggest that in mesenteric artery isolated from SHR, the impaired anticontractile influence of PVAT might significantly contribute to its increased sensitivity to adrenergic stimuli.<\/jats:p>","DOI":"10.33549\/physiolres.933434","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T10:41:39Z","timestamp":1582972899000},"page":"S391-S399","source":"Crossref","is-referenced-by-count":20,"title":["Interaction of Perivascular Adipose Tissue and Sympathetic Nerves in Arteries From Normotensive and Hypertensive Rats"],"prefix":"10.33549","author":[{"given":"J.","family":"T\u00d6R\u00d6K","sequence":"first","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"ZEMAN\u010c\u00cdKOV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"KOCIANOV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2016,10,16]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"BARTNESS TJ, RYU V: Neural control of white, beige and brown adipocytes. 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