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Moreover, cross-talk between H2S and NO has been reported. NO-H2S interactions include reactions between the molecules themselves, and each has been shown to regulate the endogenous production of the other. In addition, NO and H2S can interact to form a nitrosothiol\/s complex, which has original properties and represents a novel nitroso-sulphide signaling pathway. Furthermore, recent results have shown that the interaction between H2S and NO could be involved in the endothelium-regulated compensatory mechanisms that are observed in juvenile spontaneously hypertensive rats. The present review is devoted to role of H2S in vascular tone regulation. We primarily focus on the mechanisms of H2S-NO interactions and on the role of H2S in blood pressure regulation in normotensive and spontaneously hypertensive rats.<\/jats:p>","DOI":"10.33549\/physiolres.933438","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T10:41:16Z","timestamp":1582972876000},"page":"S273-S289","source":"Crossref","is-referenced-by-count":26,"title":["The Role of Hydrogen Sulphide in Blood Pressure Regulation"],"prefix":"10.33549","author":[{"given":"S.","family":"CACANYIOVA","sequence":"first","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"BERENYIOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"KRISTEK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2016,10,16]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ABE K, KIMURA H: The possible role of hydrogen sulfide as an endogenous neuromodulator. 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