{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:19:31Z","timestamp":1790741971607,"version":"4.1.0"},"reference-count":42,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2016,12,29]]},"abstract":"<jats:p>A\u00a02\u00d72 factorial design was used to evaluate possible preservation of mitochondrial functions in two cardioprotective experimental models, remote ischemic preconditioning and streptozotocin-induced diabetes mellitus, and their interaction during ischemia\/reperfusion injury (I\/R) of the heart. Male Wistar rats were randomly allocated into four groups: control (C), streptozotocin-induced diabetic (DM), preconditioned (RPC) and preconditioned streptozotocin-induced diabetic (DM+RPC). RPC\u00a0was conducted by 3\u00a0cycles of 5-min hind-limb ischemia and 5-min reperfusion. DM was induced by a single dose of 65\u00a0mg\/kg streptozotocin. Isolated hearts were exposed to ischemia\/ reperfusion test according to Langendorff. Thereafter mitochondria were isolated and the mitochondrial respiration was measured. Additionally, the ATP synthase activity measurements on the same preparations were done. Animals of all groups subjected to I\/R exhibited a decreased state\u00a03 respiration with the least change noted in DM+RPC group associated with no significant changes in state\u00a02 respiration. In RPC, DM and DM+RPC group, no significant changes in the activity of ATP synthase were observed after I\/R injury. These results suggest that the endogenous protective mechanisms of RPC and DM do preserve the mitochondrial function in heart when they act in combination.<\/jats:p>","DOI":"10.33549\/physiolres.933533","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T08:41:13Z","timestamp":1585730473000},"page":"S611-S619","source":"Crossref","is-referenced-by-count":6,"title":["Cardioprotection Induced by Remote Ischemic Preconditioning Preserves the Mitochondrial Respiratory Function in Acute Diabetic Myocardium"],"prefix":"10.33549","author":[{"given":"I.","family":"KANCIROV\u00c1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"JA\u0160OV\u00c1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"MUR\u00c1RIKOV\u00c1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"SUMBALOV\u00c1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"ULI\u010cN\u00c1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"RAVINGEROV\u00c1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"WACZUL\u00cdKOV\u00c1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"ZIEGELH\u00d6FFER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"FERKO","sequence":"additional","affiliation":[{"name":"Institute for Heart Research, Slovak Academy of Sciences, Centre of Excellence of SAS NOREG, Bratislava, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2016,12,17]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ANDREAS M, SCHMID AI, KEILANI M, DOBERER D, BARTKO J, CREVENNA R, MOSER E, WOLZT M: Effect of ischemic preconditioning in skeletal muscle measured by functional magnetic resonance imaging and spectroscopy: a randomized crossover trial. 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