{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:07:38Z","timestamp":1767211658662},"reference-count":33,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2016,12,29]]},"abstract":"<jats:p>Causes of early hypoperfusion after subarachnoid hemorrhage (SAH) include intracranial hypertension as well as vasoconstriction. The aim of the study was to assess the effect of intracerebroventricular (ICV) administration of sodium nitroprusside (SNP) on early hypoperfusion after SAH. Male Wistar rats (220-240\u00a0g) were used, SAH group received 250\u00a0\u03bcl of fresh autologous arterial blood into the prechiasmatic cistern; sham-operated animals received 250 \u03bcl of isotonic solution. Therapeutic intervention: ICV administration of 10\u00a0\u03bcg SNP; 5\u00a0\u03bcl 5\u00a0% glucose (SNP vehicle) and untreated control. Brain perfusion and invasive blood pressure were monitored for 30 min during and after induction of SAH. Despite SNP caused increase of perfusion in sham-operated animals, no response was observed in half of SAH animals. The other half developed hypotension accompanied by brain hypoperfusion. There was no difference between brain perfusion in SNP-treated, glucose-treated and untreated SAH animals during the monitored period. We did not observe expected beneficial effect of ICV administration of SNP after SAH. Moreover, half of the SNP-treated animals developed serious hypotension which led to brain hypoperfusion. This is the important finding showing that this is not the option for early management in patient after SAH.<\/jats:p>","DOI":"10.33549\/physiolres.933536","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T08:41:04Z","timestamp":1585730464000},"page":"S591-S599","source":"Crossref","is-referenced-by-count":3,"title":["Early Changes of Brain Perfusion After Subarachnoid Hemorrhage \u2013 the Effect of Sodium Nitroprusside"],"prefix":"10.33549","author":[{"given":"M.","family":"KOLAR","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"NOHEJLOVA","sequence":"additional","affiliation":[{"name":"Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"MARES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"PACHL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2016,12,17]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"AGRAWAL A, PATIR R, KATO Y, CHOPRA S, SANO H, KANNO T: Role of intraventricular sodium nitroprusside in vasospasm secondary to aneurysmal subarachnoid haemorrhage: a 5-year prospective study with review of the literature. Minim Invasive Neurosurg 52: 5-8, 2009.","DOI":"10.1055\/s-0028-1085454"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"BEDERSON JB, GERMANO IM, GUARINO L: Cortical blood flow and cerebral perfusion pressure in a new noncraniotomy model of subarachnoid hemorrhage in the rat. Stroke 26: 1086-1092, 1995.","DOI":"10.1161\/01.str.26.6.1086"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"BEDERSON JB, LEVY AL, DING WH, KAHN R, DIPERNA CA, JENKINS AL 3RD, VALLABHAJOSYULA P: Acute vasoconstriction after subarachnoid hemorrhage. Neurosurgery 42: 352-362, 1998.","DOI":"10.1097\/00006123-199802000-00091"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"BRODERICK JP, BROTT TG, DULDNER JE, TOMSICK T, LEACH A: Initial and recurrent bleeding are the major causes of death following subarachnoid hemorrhage. Stroke 25: 1342-1347, 1994.","DOI":"10.1161\/01.str.25.7.1342"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"BUHLER D, AZGHANDI S, SCHULLER K, PLESNILA N: Effect of decompressive craniectomy on outcome following subarachnoid hemorrhage in mice. Stroke 46: 819-826, 2015.","DOI":"10.1161\/strokeaha.114.007703"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"CAHILL J, CALVERT JW, ZHANG JH: Mechanisms of early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 26: 1341-1353, 2006.","DOI":"10.1038\/sj.jcbfm.9600307"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"CHANG CP, PAN SP, LIN MT: A nitric oxide-dopamine link pathway in organum vasculosum laminae terminalis of rat brain exerts control over blood pressure. Br J Pharmacol 132: 1524-1530, 2001.","DOI":"10.1038\/sj.bjp.0703948"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"CLARK JF, SHARP FR: Bilirubin oxidation products (BOXes) and their role in cerebral vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metab 26: 1223-1233, 2006.","DOI":"10.1038\/sj.jcbfm.9600280"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"EGEMEN N, TURKER RK, SANLIDILEK U, ZORLUTUNA A, BILGIC S, BASKAYA M, UNLU A, CAGLAR S, SPETZLER RF, MCCORMICK JM: The effect of intrathecal sodium nitroprusside on severe chronic vasospasm. Neurol Res 15: 310-315, 1993.","DOI":"10.1080\/01616412.1993.11740153"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"FRIEDRICH V, FLORES R, MULLER A, BI W, PEERSCHKE EI, SEHBA FA: Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage. J Neuroinflammation 8: 103, 2011.","DOI":"10.1186\/1742-2094-8-103"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"HELMS C, KIM-SHAPIRO DB: Hemoglobin-mediated nitric oxide signaling. Free Radic Biol Med 61: 464-472, 2013.","DOI":"10.1016\/j.freeradbiomed.2013.04.028"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"KAJITA Y, SUZUKI Y, OYAMA H, TANAZAWA T, TAKAYASU M, SHIBUYA M, SUGITA K: Combined effect of L-arginine and superoxide dismutase on the spastic basilar artery after subarachnoid hemorrhage in dogs. J\u00a0Neurosurg 80: 476-483, 1994.","DOI":"10.3171\/jns.1994.80.3.0476"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"LANG EW, LAGOPOULOS J, GRIFFITH J, YIP K, YAM A, MUDALIAR Y, MEHDORN HM, DORSCH NW: Cerebral vasomotor reactivity testing in head injury: the link between pressure and flow. J Neurol Neurosurg Psychiatry 74: 1053-1059, 2003.","DOI":"10.1136\/jnnp.74.8.1053"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"LI Q, CHEN Y, LI B, LUO C, ZUO S, LIU X, ZHANG JH, RUAN H, FENG H: Hemoglobin induced NO\/cGMP suppression deteriorate microcirculation via pericyte phenotype transformation after subarachnoid hemorrhage in rats. Sci Rep 6: 22070, 2016.","DOI":"10.1038\/srep22070"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"LIN MT, PAN SP, LIN JH, YANG YL: Central control of blood pressure by nitrergic mechanisms in organum vasculosum laminae terminalis of rat brain. Br J Pharmacol 127: 1511-1517, 1999.","DOI":"10.1038\/sj.bjp.0702699"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"MARMAROU A, SHULMAN K, LAMORGESE J: Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system. J Neurosurg 43: 523-534, 1975.","DOI":"10.3171\/jns.1975.43.5.0523"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"NAFF NJ, WILLIAMS MA, RIGAMONTI D, KEYL PM, HANLEY DF: Blood clot resolution in human cerebrospinal fluid: evidence of first-order kinetics. Neurosurgery 49: 614-621, 2001.","DOI":"10.1227\/00006123-200109000-00015"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"PACHL J, HANINEC P, TENCER T, MIZNER P, HOUST'AVA L, TOMAS R, WALDAUF P: The effect of subarachnoid sodium nitroprusside on the prevention of vasospasm in subarachnoid haemorrhage. Acta Neurochir Suppl 95: 141-145, 2005.","DOI":"10.1007\/3-211-32318-x_31"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"PLUTA RM, BUTMAN JA, SCHATLO B, JOHNSON DL, OLDFIELD EH: Subarachnoid hemorrhage and the distribution of drugs delivered into the cerebrospinal fluid. Laboratory investigation. J Neurosurg 111: 1001-1007, 1-4, 2009.","DOI":"10.3171\/2009.2.jns081256"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"PRUNELL GF, MATHIESEN T, SVENDGAARD NA: A new experimental model in rats for study of the pathophysiology of subarachnoid hemorrhage. Neuroreport 13: 2553-2556, 2002.","DOI":"10.1097\/00001756-200212200-00034"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"PRUNELL GF, MATHIESEN T, DIEMER NH, SVENDGAARD NA: Experimental subarachnoid hemorrhage: subarachnoid blood volume, mortality rate, neuronal death, cerebral blood flow, and perfusion pressure in three different rat models. Neurosurgery 52: 165-176, 2003.","DOI":"10.1227\/00006123-200301000-00022"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"RAABE A, ZIMMERMANN M, SETZER M, VATTER H, BERKEFELD J, SEIFERT V: Effect of intraventricular sodium nitroprusside on cerebral hemodynamics and oxygenation in poor-grade aneurysm patients with severe, medically refractory vasospasm. Neurosurgery 50: 1006-1014, 2002.","DOI":"10.1227\/00006123-200205000-00013"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"SCHUBERT GA, SCHILLING L, THOME C: Clazosentan, an endothelin receptor antagonist, prevents early hypoperfusion during the acute phase of massive experimental subarachnoid hemorrhage: a laser Doppler flowmetry study in rats. J Neurosurg 109: 1134-1140, 2008.","DOI":"10.3171\/jns.2008.109.12.1134"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"SCHUBERT GA, SEIZ M, HEGEWALD AA, MANVILLE J, THOME C: Acute hypoperfusion immediately after subarachnoid hemorrhage: a xenon contrast-enhanced CT study. J Neurotrauma 26: 2225-2231, 2009.","DOI":"10.1089\/neu.2009.0924"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"SCHWARTZ AY, MASAGO A, SEHBA FA, BEDERSON JB: Experimental models of subarachnoid hemorrhage in the rat: a refinement of the endovascular filament model. J Neurosci Methods 96: 161-167, 2000a.","DOI":"10.1016\/s0165-0270(00)00156-4"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"SCHWARTZ AY, SEHBA FA, BEDERSON JB: Decreased nitric oxide availability contributes to acute cerebral ischemia after subarachnoid hemorrhage. Neurosurgery 47: 208-215, 2000b.","DOI":"10.1227\/00006123-200007000-00042"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"SEHBA FA, DING WH, CHERESHNEV I, BEDERSON JB: Effects of S-nitrosoglutathione on acute vasoconstriction and glutamate release after subarachnoid hemorrhage. Stroke 30: 1955-1961, 1999.","DOI":"10.1161\/01.str.30.9.1955"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"SEHBA FA, SCHWARTZ AY, CHERESHNEV I, BEDERSON JB: Acute decrease in cerebral nitric oxide levels after subarachnoid hemorrhage. J Cereb Blood Flow Metab 20: 604-611, 2000.","DOI":"10.1097\/00004647-200003000-00018"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"SEHBA FA, FRIEDRICH V JR, MAKONNEN G, BEDERSON JB: Acute cerebral vascular injury after subarachnoid hemorrhage and its prevention by administration of a nitric oxide donor. J Neurosurg 106: 321-329, 2007.","DOI":"10.3171\/jns.2007.106.2.321"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"SEHBA FA, HOU J, PLUTA RM, ZHANG JH: The importance of early brain injury after subarachnoid hemorrhage. Prog Neurobiol 97: 14-37, 2012.","DOI":"10.1016\/j.pneurobio.2012.02.003"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"STREBEL S, KAUFMANN M, MAITRE L, SCHAEFER HG: Effects of ketamine on cerebral blood flow velocity in humans. Influence of pretreatment with midazolam or esmolol. Anaesthesia 50: 223-228, 1995.","DOI":"10.1111\/j.1365-2044.1995.tb04561.x"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"THOMAS JE, ROSENWASSER RH, ARMONDA RA, HARROP J, MITCHELL W, GALARIA I: Safety of intrathecal sodium nitroprusside for the treatment and prevention of refractory cerebral vasospasm and ischemia in humans. Stroke 30: 1409-1416, 1999.","DOI":"10.1161\/01.str.30.7.1409"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"VATTER H, WEIDAUER S, DIAS S, PREIBISCH C, NGONE S, RAABE A, ZIMMERMANN M, SEIFERT V: Persistence of the nitric oxide-dependent vasodilator pathway of cerebral vessels after experimental subarachnoid hemorrhage. Neurosurgery 60: 179-188, 2007.","DOI":"10.1227\/01.neu.0000249212.96719.95"}],"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T08:41:07Z","timestamp":1585730467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/65%20Suppl%205\/65_S591.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,17]]},"references-count":33,"URL":"https:\/\/doi.org\/10.33549\/physiolres.933536","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12,17]]}}}