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Hypoxic-ischemic changes trigger several molecular and cellular processes leading to cell death and inflammation. Generated reactive oxygen species attack surrounding cellular components resulting in functional deficits and mitochondrial dysfunction. The aim of the present paper is to review present knowledge about the pathophysiology of perinatal hypoxic-ischemic encephalopathy, especially with respect to novel treatment strategies and biomarkers that might enhance early detection of this disorder and thus improve the general outcome of patients.<\/jats:p>","DOI":"10.33549\/physiolres.933541","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T08:40:43Z","timestamp":1585730443000},"page":"S533-S545","source":"Crossref","is-referenced-by-count":48,"title":["Pathophysiology of Perinatal Hypoxic-Ischemic Encephalopathy \u2013 Biomarkers, Animal Models and Treatment Perspectives"],"prefix":"10.33549","author":[{"given":"V.","family":"RILJAK","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"KRAF","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"DARYANANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"JIRU\u0160KA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"OT\u00c1HAL","sequence":"additional","affiliation":[{"name":"Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2016,12,17]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ALEXANDER M, GARBUS H, SMITH AL, ROSENKRANTZ TS, FITCH RH: Behavioral and histological outcomes following neonatal HI injury in a preterm (P3) and term (P7) rodent model. 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