{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:03:43Z","timestamp":1780376623021,"version":"3.54.1"},"reference-count":41,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2017,4,30]]},"abstract":"<jats:p>The first experimental model of atherosclerosis (in rabbits) is more than hundred years old. Several animal species have been used to produce hyperlipoproteinemia and possible atherosclerosis. The gene manipulation produced the most used models recently. This review acknowledges the extensive study of atherosclerotic changes in experimental models of hyperlipoproteinemia and atherosclerosis to come to light thus far and the purpose here is not only to summarize the published data but also to try to add some details of our experience in using these models. In addition to rabbit (the old but also improved model by reno-vascular hypertension) dog, birds, pig, hamster, mice, rat and non-human primate\u2019s animal models are described. The gene manipulation produced the most used models two decades ago. Germline genetically engineered (without apoE or LDL receptor genes) animals have become the most used models producing atherosclerotic changes in the aorta. Recent new models also producing atherosclerotic changes but without germline genetic manipulation are also described.<\/jats:p>","DOI":"10.33549\/physiolres.933585","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T08:12:23Z","timestamp":1580371943000},"page":"S69-S75","source":"Crossref","is-referenced-by-count":22,"title":["Experimental Models of Hyperlipoproteinemia and Atherosclerosis"],"prefix":"10.33549","author":[{"given":"R.","family":"POLEDNE","sequence":"first","affiliation":[{"name":"Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"JUR\u010c\u00cdKOV\u00c1-NOVOTN\u00c1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2017,4,15]]},"reference":[{"key":"ref0","unstructured":"ANITSCHKOV N, CHELATOV S: On experimental cholesterin steatosis and its significance in the origin of some pathological processes (in German). 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