{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:22:36Z","timestamp":1768735356068,"version":"3.49.0"},"reference-count":29,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2018,6,30]]},"abstract":"<jats:p>Alcohol abuse during pregnancy is a well-known factor in fetal morbidity, including smaller fetal size. We have shown that chronic hypoxia, considered the main pathogenetic factor in intrauterine growth restriction, elevates fetoplacental vascular resistance (and vasoconstrictor reactivity) and thus, presumably, reduces placental blood flow. We thus hypothesized that alcohol may affect the fetus \u2013 in addition to other mechanisms \u2013 by altering fetoplacental vascular resistance and\/or reactivity. Using isolated, double-perfused rat placenta model, we found that maternal alcohol intake in the last third of gestation doubled the vasoconstrictor responses to angiotensin II but did not affect resting vascular resistance. Reactivity to acute hypoxic challenges was unchanged. Chronic maternal alcohol intake in a rat model alters fetoplacental vasculature reactivity; nevertheless, these changes do not appear as serious as other detrimental effects of alcohol on the fetus.<\/jats:p>","DOI":"10.33549\/physiolres.933609","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T15:49:33Z","timestamp":1559836173000},"page":"509-513","source":"Crossref","is-referenced-by-count":3,"title":["Alcohol and Fetoplacental Vasoconstrictor Reactivity"],"prefix":"10.33549","author":[{"given":"V.","family":"JAKOUBEK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"HAMPL","sequence":"additional","affiliation":[{"name":"Department of Physiology, Second Medical School, Charles University, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2018,6,23]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ANTON L, BROSNIHAN KB: Systemic and uteroplacental renin\u2013angiotensin system in normal and pre-eclamptic pregnancies. 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