{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:08:33Z","timestamp":1787026113503,"version":"build-2736575974"},"reference-count":28,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2018,10,31]]},"abstract":"<jats:p>The aim of study was to review the status of arterial pH, pO2 and pCO2 under general anesthesias in dependence on the light-dark (LD) cycle in spontaneously breathing rats. The experiments were performed using three- to four-month-old pentobarbital(P)-, ketamine\/xylazine(K\/X)- and zoletil(Z)-anesthetized female Wistar rats after a four-week adaptation to an LD cycle (12 h light:12 h dark). The animals were divided into three experimental groups according to the anesthetic agent used: P (light n=11; dark n=8); K\/X (light n=13; dark n=11); and Z (light n=18; dark n=26). pH and blood gases from arterial blood were analyzed. In P anesthesia, LD differences in pH, pO2, and pCO2 were eliminated. In K\/X anesthesia, parameters showed significant LD differences. In Z anesthesia, LD differences were detected for pH and pO2 only. Acidosis, hypoxia, and hypercapnia have been reported for all types of anesthesia during the light period. In the dark period, except for P anesthesia, the environment was more stable and values fluctuated within normal ranges. From a chronobiological perspective, P anesthesia was not the most appropriate type of anesthesia in these rat experiments. It eliminated LD differences, and also produced a more acidic environment and more pronounced hypercapnia than K\/X and Z anesthesias.<\/jats:p>","DOI":"10.33549\/physiolres.933692","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T11:04:55Z","timestamp":1564052695000},"page":"721-728","source":"Crossref","is-referenced-by-count":14,"title":["Arterial pH and Blood Gas Values in Rats Under Three Types of General Anesthesia: a Chronobiological Study"],"prefix":"10.33549","author":[{"given":"P.","family":"SVORC","sequence":"first","affiliation":[{"name":"Department of Physiology, Medical Faculty Safarik\u2019s University, Kosice, Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"PETR\u00c1\u0160OV\u00c1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"P.","family":"SVORC","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"BRUN-PASCAUD M, GAUDEBOUT C, BLAYO MC, POCIDALO JJ: Arterial blood gases and acid-base status in awake rats. 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