{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:51:26Z","timestamp":1778734286702,"version":"3.51.4"},"reference-count":26,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2018,10,31]]},"abstract":"<jats:p>In this study we set out to understand is sleep fragmentation affects the cardiovascular regulation and circadian variability of core body temperature more or less than sleep deprivation. 50 healthy men (age 29.0\u00b13.1 years; BMI 24.3\u00b12.1 kg\/m2) participated in a 3-day study that included one adaptative night and one experimental night involving randomization to: sleep deprivation (SD) and sleep fragmentation (SF). The evaluation included hemodynamic parameters, measures of the spectral analysis of heart rate and blood pressure variability, and the sensitivity of arterial baroreflex function. Core body temperature (CBT) was measured with a telemetric system. SF affects heart rate (61.9\u00b15.6 vs. 56.2\u00b17.6, p&lt;0.01) and stroke index (52.7\u00b111.1 vs. 59.8\u00b112.2, p&lt;0.05) with significant changes in the activity of the ANS (LF-sBP: 6.0\u00b15.3 vs. 3.4\u00b13.7, p&lt;0.05; HF-sBP: 1.8\u00b11.8 vs. 1.0\u00b10.7, p&lt;0.05; LF-dBP: 5.9\u00b14.7 vs. 3.5\u00b13.2, p&lt;0.05) more than SD. Post hoc analysis revealed that after SD mean value of CBT from 21:30 to 06:30 was significantly higher compared to normal night\u2019s sleep and SF. In healthy men SF affects the hemodynamic and autonomic changes more than SD. Sympathetic overactivity is the proposed underlying mechanism.<\/jats:p>","DOI":"10.33549\/physiolres.933758","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T15:04:45Z","timestamp":1564067085000},"page":"687-693","source":"Crossref","is-referenced-by-count":14,"title":["Cardiovascular Regulation and Body Temperature: Evidence From a Nap vs. Sleep Deprivation Randomized Controlled Trial"],"prefix":"10.33549","author":[{"given":"J.","family":"S\u0141OMKO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"ZAWADKA-KUNIKOWSKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"KLAWE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"TAFIL-KLAWE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"NEWTON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"ZALEWSKI","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Ergonomics, Nicolaus Copernicus University in Torun, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"BONNET MH, ARAND DL: Heart rate variability: sleep stage, time of night, and arousal influences. Electroencephalogr Clin Neurophysiol 102: 390-396, 1997.","DOI":"10.1016\/s0921-884x(96)96070-1"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"BYRNE CH, LIM CHL: The ingestible telemetric body core temperature sensor: a review of validity and exercise applications. Br J Sports Med 41: 126-133, 2007.","DOI":"10.1136\/bjsm.2006.026344"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"CHOUCHOU F, PICHOT V, PEPIN JL, TAMISIER R, CELLE S, MAUDOUX D, GARCIN A, LEVY P, BARTHELEMY JC, ROCHE F, PROOF STUDY GROUP: Sympathetic overactivity due to sleep fragmentation is associated with elevated diurnal systolic blood pressure in healthy elderly subjects: the PROOF-SYNAPSE study. Eur Heart J 34: 2122-2131, 2131a, 2013.","DOI":"10.1093\/eurheartj\/eht208"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"DETTONI JL, CONSOLIM-COLOMBO FM, DRAGER LF, RUBIRA MC, SOUZA SB, IRIGOYEN MC, MOSTARDA C, BORILE S, KRIEGER EM, MORENO H, LORENZI-FILHO G: Cardiovascular effects of partial sleep deprivation in healthy volunteers. J Appl Physiol 113: 232-236, 2012.","DOI":"10.1152\/japplphysiol.01604.2011"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"FARAUT B, ANDRILLON T, VECCHIERINI MF, LEGER D: Napping: A public health issue. From epidemiological to laboratory studies. Sleep Med Rev 35: 85-100, 2017.","DOI":"10.1016\/j.smrv.2016.09.002"},{"key":"ref5","unstructured":"FORTIN J, KLINGER T, WAGNER CH, STERNER H, MADRITSCH CH, GRULLENBERGER R: The task force monitor \u2013 a non-invasive beat-to-beat monitor for hemodynamic and autonomic function of the human body. Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 1998, Hong Kong."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"FORTIN J, MARTE W, GRULLENBERG R: Continuous non-invasive blood pressure monitoring using concentrically interlocking control loops. Comput Biol Med 36: 941-957, 2006.","DOI":"10.1016\/j.compbiomed.2005.04.003"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"FULBROOK P: Core body temperature measurement: a comparison of axilla, tympanic membrane and pulmonary artery blood temperature. Intensive Crit Care Nurs 13: 266-272, 1997.","DOI":"10.1016\/s0964-3397(97)80425-9"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"GANGWISCH JE: A review of evidence for the link between sleep duration and hypertension. Am J Hypertens 27: 1235-1242, 2014.","DOI":"10.1093\/ajh\/hpu071"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"GIULIANO KK, SCOTT SS, ELLIOT S, GIULIANO AJ: Temperature measurement in critically ill orally intubated adults: a comparison of pulmonary artery core, tympanic, and oral methods. Crit Care Med 27: 2188-2193, 1999.","DOI":"10.1097\/00003246-199910000-00020"},{"key":"ref10","unstructured":"GUPTA S, PATI AK: Desynchronization of circadian rhythms in a group of shift working nurses: effects of pattern of shift rotation. J Hum Ergol (Tokyo) 23: 121-131, 1994."},{"key":"ref11","unstructured":"KELLY GS: Body temperature variability (Part 2): masking influences of body temperature variability and a review of body temperature variability in disease. Altern Med Rev 12: 49-62, 2007."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"KRAUCHI K: How is the circadian rhythm of core body temperature regulated? Clin Auton Res 12: 147-149, 2002.","DOI":"10.1007\/s10286-002-0043-9"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"KRAUCHI K, WIRZ-JUSTICE A: Circadian clues to sleep onset mechanisms. Neuropsychopharmacology 25 (5 Suppl): S92-S96, 2001.","DOI":"10.1016\/s0893-133x(01)00315-3"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"KRAUCHI K, WIRZ-JUSTICE A: Circadian rhythm of heat production, heart rate, and skin and core temperature under unmasking conditions in men. Am J Physiol 267: R819-R829, 1994.","DOI":"10.1152\/ajpregu.1994.267.3.r819"},{"key":"ref15","unstructured":"LAUNAY JC, SAVOUREY G, GUINET A, LALLEMENT G, BESNARD Y, BITTEL J: Circadian rhythm of rectal temperature during sleep deprivation with modafinil. Aviat Space Environ Med 73: 985-990, 2002."},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"LIM CHL, BYRNE CH, LEE JKW: Human thermoregulation and measurement of body temperature in exercise and clinical settings. Ann Acad Med Singapore 37: 347-353, 2008.","DOI":"10.47102\/annals-acadmedsg.V37N4p347"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"MANCIA G: Autonomic modulation of the cardiovascular system during sleep. N Engl J Med 328: 347-349, 1993.","DOI":"10.1056\/NEJM199302043280511"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"MCKENZIE JE, OSGOOD DW: Validation of a new telemetric core temperature monitor. J Therm Biol 29: 605-611, 2004.","DOI":"10.1016\/j.jtherbio.2004.08.020"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"MORRIS CHJ, YANG JN, SCHEER JL: The impact of the circadian timing system on cardiovascular and metabolic function. Prog Brain Res 199: 337-358, 2012.","DOI":"10.1016\/b978-0-444-59427-3.00019-8"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"MURRAY EJ, WILLIAMS HL, LUBIN A: Body temperature and psychological ratings during sleep deprivation. J Exp Psychol 56: 271-273, 1958.","DOI":"10.1037\/h0048421"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"PALMA JA, URRENSTARAZU E, IRIARTE J: Sleep loss as a risk factor of neurologic disorders: A review. Sleep Med 14: 229-236, 2013.","DOI":"10.1016\/j.sleep.2012.11.019"},{"key":"ref22","unstructured":"PATI AK, SAINI SK: Desynchronization of oral temperature, pulse and performance circadian rhythms in shift working Indian nurses. Indian J Exp Biol 29: 1017-1021, 1991."},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"SMYTH HS, SLEIGHT P, PICKERING GW: Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity. Circ Res 24: 109-121, 1969.","DOI":"10.1161\/01.res.24.1.109"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"THOMAS SJ, CALHOUN D: Sleep, insomnia, and hypertension: current findings and future directions. J Am Soc Hypertens 11: 122-129, 2017.","DOI":"10.1016\/j.jash.2016.11.008"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"VAARA J, KYROLAINEN H, KOIVU M, TULPPO M, FINNI T: The effect of 60-h sleep deprivation on cardiovascular regulation and body temperature. Eur J Appl Physiol 105: 439-444, 2009.","DOI":"10.1007\/s00421-008-0921-5"}],"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T15:00:27Z","timestamp":1695049227000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomed.cas.cz\/physiolres\/pdf\/67\/67_687.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,25]]},"references-count":26,"URL":"https:\/\/doi.org\/10.33549\/physiolres.933758","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10,25]]}}}