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Moreover, in SHR, body weight and relative heart weight were increased after treatment with fructose. In superior mesenteric arteries, PVAT exerted inhibitory influence on adrenergic contractile responses and this effect was markedly stronger in control WKY than in SHR. In fructose-administered WKY, arterial adrenergic contractions were substantially reduced in comparison with the control group; this was caused mainly by enhancement of anticontractile action of PVAT. The diminution of the mesenteric arterial contractions was not observed after fructose treatment in SHR. We conclude that the increase in body adiposity due to fructose overfeeding in rats might have pro-hypertensive effect. However, in WKY it might cause PVAT-dependent and independent reduction in arterial contractile responses to adrenergic stimuli, which could attenuate the pathological elevation in vascular tone.<\/jats:p>","DOI":"10.33549\/physiolres.933798","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T07:51:48Z","timestamp":1581061908000},"page":"S537-S544","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Perivascular Adipose Tissue on Arterial Adrenergic Contractions in Normotensive and Hypertensive Rats With High Fructose Intake"],"prefix":"10.33549","author":[{"given":"A.","family":"ZEMAN\u010c\u00cdKOV\u00c1","sequence":"first","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"T\u00d6R\u00d6K","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"AGHAMOHAMMADZADEH R, UNWIN RD, GREENSTEIN AS, HEAGERTY AM: Effects of obesity on perivascular adipose tissue vasorelaxant function: nitric oxide, inflammation and elevated systemic blood pressure. 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Physiol Res 65 (Suppl 3): S391-S399, 2016.","DOI":"10.33549\/physiolres.933434"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"UCHIDA Y, UCHIDA Y, SHIMOYAMA E, HIRUTA N, KISHIMOTO T, WATANABE S: Pericoronary adipose tissue as storage and supply site for oxidized low-density lipoprotein in human coronary plaques. PLoS One 11: e0150862, 2016.","DOI":"10.1371\/journal.pone.0150862"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"VAN\u011a\u010cKOV\u00c1 I, MALET\u00cdNSK\u00c1 L, BEHULIAK M, NAGELOV\u00c1 V, ZICHA J, KUNE\u0160 J: Obesity-related hypertension: possible pathophysiological mechanisms. J Endocrinol 223: R63-R78, 2014.","DOI":"10.1530\/joe-14-0368"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"VERLOHREN S, DUBROVSKA G, TSANG SY, ESSIN K, LUFT FC, HUANG Y, GOLLASCH M: Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries. 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