{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T07:07:12Z","timestamp":1723619232246},"reference-count":19,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2018,12,28]]},"abstract":"<jats:p>Cardiac resynchronization therapy (CRT) has proven efficacious in the treatment of patients with heart failure and dyssynchronous activation. Currently, we select suitable CRT candidates based on the QRS complex duration (QRSd) and morphology with left bundle branch block being the optimal substrate for resynchronization. To improve CRT response rates, recommendations emphasize attention to electrical parameters both before implant and after it. Therefore, we decided to study activation times before and after CRT on the body surface potential maps (BSPM) and to compare thus obtained results with data from electroanatomical mapping using the CARTO system. Total of 21 CRT recipients with symptomatic heart failure (NYHA II-IV), sinus rhythm, and QRSd \u2265150 ms and 7 healthy controls were studied. The maximum QRSd and the longest and shortest activation times (ATmax and ATmin) were set in the BSPM maps and their locations on the chest were compared with CARTO derived time interval and site of the latest (LATmax) and earliest (LATmin) ventricular activation. In CRT patients, all these parameters were measured during both spontaneous rhythm and biventricular pacing (BVP) and compared with the findings during the spontaneous sinus rhythm in the healthy controls. QRSd was 169.7\u00b112.1 ms during spontaneous rhythm in the CRT group and 104.3\u00b110.2 ms after CRT (p&lt;0.01). In the control group the QRSd was significantly shorter: 95.1\u00b15.6 ms (p&lt;0.01). There was a good correlation between LATmin(CARTO) and ATmin(BSPM). Both LATmin and ATmin were shorter in the control group (LATmin(CARTO) 24.8\u00b17.1 ms and ATmin(BSPM) 29.6\u00b111.3 ms, NS) than in CRT group (LATmin(CARTO) was 48.1\u00b16.8 ms and ATmin(BSPM) 51.6\u00b110.1 ms, NS). BVP produced shortening compared to the spontaneous rhythm of CRT recipients (LATmin(CARTO) 31.6\u00b15.3 ms and ATmin(BSPM) 35.2\u00b112.6 ms; p&lt;0.01 spontaneous rhythm versus BVP). ATmax exhibited greater differences between both methods with higher values in BSPM: in the control group LATmax(CARTO) was 72.0\u00b14.1 ms and ATmax (BSPM) 92.5\u00b19.4 ms (p&lt;0.01), in the CRT candidates LATmax(CARTO) reached only 106.1\u00b16.8 ms whereas ATmax(BSPM) 146.0\u00b112.1 ms (p&lt;0.05), and BVP paced rhythm in CRT group produced improvement with LATmax(CARTO) 92.2\u00b17.1 ms and ATmax(BSPM) 130.9\u00b111.0 ms (p&lt;0.01 before and during BVP). With regard to the propagation of ATmin and ATmax on the body surface, earliest activation projected most often frontally in all 3 groups, whereas projection of ATmax on the body surface was more variable. Our results suggest that compared to invasive electroanatomical mapping BSPM reflects well time of the earliest activation, however provides longer time-intervals for sites of late activation. Projection of both early and late activated regions of the heart on the body surface is more variable than expected, very likely due to changed LV geometry and interposed tissues between the heart and superficial ECG electrode.<\/jats:p>","DOI":"10.33549\/physiolres.934056","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T12:59:18Z","timestamp":1573736358000},"page":"S601-S610","source":"Crossref","is-referenced-by-count":5,"title":["Outcome of Resynchronization Therapy on Superficial and Endocardial Electrophysiological Findings"],"prefix":"10.33549","author":[{"given":"O.","family":"KITTNAR","sequence":"first","affiliation":[{"name":"Institute of Physiology, First Faculty of Medicine, Charles University in Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"RIEDLBAUCHOV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"ADLA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"SUCH\u00c1NEK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"TOMIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"LO\u017dEK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"VALERI\u00c1NOV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"HRACHOVINA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"POPKOV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"VESELKA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"JANOU\u0160EK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"LHOTSK\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"AKAHOSHI M, HIRAI M, INDEN Y, SANO H, SHIMIZU A, KONDO T, MAKINO M, HORIBA M, YOSHIDA Y, TSUBOI N, HIRAYAMA H, ITO T, HAYASHI H, SAITO H: Body-surface distribution of changes in activation-recovery intervals before and after catheter ablation in patients with Wolff-Parkinson-White syndrome: clinical evidence for ventricular 'electrical remodeling' with prolongation of action-potential duration over a preexcited area. Circulation 96: 1566-1574, 1997.","DOI":"10.1161\/01.cir.96.5.1566"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"AUGER D, BLEEKER GB, BERTINI M, EWE SH, VAN BOMMEL RJ, WITKOWSKI TG, NG AC, VAN ERVEN L, SCHALIJ MJ, BAX JJ, DELGADO V: Effect of cardiac resynchronization therapy in patients without left ventricular dyssynchrony. Eur Heart J 33: 913-920, 2012.","DOI":"10.1093\/eurheartj\/ehr468"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"AURICCHIO A, FANTONI C, REGOLI F, CARBUCICCHIO C, GOETTE A, GELLER C, KLOSS M, KLEIN H: Characterization of left ventricular activation in patients with heart failure and left bundle-branch block. Circulation 109: 1133-1139, 2004.","DOI":"10.1161\/01.cir.0000118502.91105.f6"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"BANK AJ, GAGE RM, CURTIN AE, BURNS KV, GILLBERG JM, GHOSH S: Body surface activation mapping of electrical dyssynchrony in cardiac resynchronization therapy patients: potential for optimization. J Electrocardiol 51: 534-541, 2018.","DOI":"10.1016\/j.jelectrocard.2017.12.004"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"BLEEKER GB, SCHALIJ MJ, MOLHOEK SG, VERWEY HF, HOLMAN ER, BOERSMA E, STEENDIJK P, VAN DER WALL EE, BAX JJ: Relationship between QRS duration and left ventricular dyssynchrony in patients with end-stage heart failure. J Cardiovasc Electrophysiol 15: 544-549, 2004.","DOI":"10.1046\/j.1540-8167.2004.03604.x"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"CERQUEIRA MD, WEISSMAN NJ, DILSIZIAN V, JACOBS AK, KAUL S, LASKEY WK, PENNELL DJ, RUMBERGER JA, RYAN T, VERANI MS, AMERICAN HEART ASSOCIATION WRITING GROUP ON MYOCARDIAL SEGMENTATION AND REGISTRATION FOR CARDIAC IMAGING: Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 105: 539-542, 2002.","DOI":"10.1161\/hc0402.102975"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"DE POOTER J, EL HADDAD M, KAMOEN V, KALLUPURACKAL TT, STROOBANDT R, DE BUYZERE M, TIMMERMANS F: Relation between electrical and mechanical dyssynchrony in patients with left bundle branch block: An electro- and vectorcardiographic study. Ann Noninvasive Electrocardiol 23: e12525, 2018.","DOI":"10.1111\/anec.12525"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"DICKSTEIN K, VARDAS PE, AURICCHIO A, DAUBERT JC, LINDE C, MCMURRAY J, PONIKOWSKI P, PRIORI SG, SUTTON R, VAN VELDHUISEN DJ, VAHANIAN A, BAX J, CECONI C, DEAN V, FILIPPATOS G, FUNCK-BRENTANO C, HOBBS R, KEARNEY P, MCDONAGH T, POPESCU BA, REINER Z, SECHTEM U, SIRNES PA, TENDERA M, VARDAS P, WIDIMSKY P, ANKER SD, BLANC JJ, GASPARINI M, HOES AW, ISRAEL CW, KALARUS Z, MERKELY B, SWEDBERG K, CAMM AJ: 2010 Focused Update of ESC Guidelines on device therapy in heart failure: an update of the 2008 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC guidelines for cardiac and resynchronization therapy. Developed with the special contribution of the Heart Failure Association and the European Heart Rhythm Association. Eur Heart J 31: 2677-2687, 2010.","DOI":"10.1093\/eurheartj\/ehq337"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"FAUCHIER L, MARIE O, CASSET-SENON D, BABUTY D, COSNAY P, FAUCHIER JP: Interventricular and intraventricular dyssynchrony in idiopathic dilated cardiomyopathy: a prognostic study with Fourier phase analysis of radionuclide scintigraphy. J Am Coll Cardiol 40: 2022-2030, 2002.","DOI":"10.1016\/s0735-1097(02)02569-x"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"KIRK JA, KASS DA: Electromechanical dyssynchrony and resynchronization of the failing heart. Circ Res 113: 765-776, 2013.","DOI":"10.1161\/circresaha.113.300270"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"KITTNAR O, ML\u010cEK M: Analysis of the electrical heart field. Physiol Res 59 (Suppl 1): S19-S24. 2010.","DOI":"10.33549\/physiolres.932004"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"KITTNAR O, RIEDLBAUCHOV\u00c1 L, TOMIS J, LO\u017dEK M, VALERI\u00c1NOV\u00c1 A, HRACHOVINA M, ML\u010cEK M, HUPTYCH M, JANOU\u0160EK J, LHOTSK\u00c1 L: Electrocardiographic outcome of resynchronization therapy. Physiol Res 66 (Suppl 4): S523-S528, 2017.","DOI":"10.33549\/physiolres.933805"},{"key":"ref12","unstructured":"KITTNAR O, \u0160\u0164OV\u00cd\u010cEK P: Contemporary body surface potential mapping in electrocardiology and its perspectives. Physiol Res 42: 141-143, 1993."},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"LASZLO R, KONZ H, KUNZ K, DALLMEIER D, KLENK J, DENKINGER M, KOENIG W, ROTHENBACHER D, STEINACKER JM FOR THE ACTIFE STUDY GROUP: Evaluation of left and right ventricular systolic and diastolic electromechanical synchrony in older people: a population-based observational study. Physiol Res 66: 933-948, 2017.","DOI":"10.1007\/s40520-016-0667-6"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"LINDE C, CLELAND JGF, GOLD MR, CLAUDE DAUBERT J, TANG ASL, YOUNG JB, SHERFESEE L, ABRAHAM WT: The interaction of sex, height, and QRS duration on the effects of cardiac resynchronization therapy on morbidity and mortality: an individual-patient data meta-analysis. Eur J Heart Fail 20: 780-791, 2018.","DOI":"10.1002\/ejhf.1133"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"PONIKOWSKI P, VOORS AA, ANKER SD, BUENO H, CLELAND JG, COATS AJ, FALK V, GONZ\u00c1LEZ-JUANATEY JR, HARJOLA VP, JANKOWSKA EA, JESSUP M, LINDE C, NIHOYANNOPOULOS P, PARISSIS JT, PIESKE B, RILEY JP, ROSANO GM, RUILOPE LM, RUSCHITZKA F, RUTTEN FH, VAN DER MEER P: 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 18: 891-975, 2016.","DOI":"10.5603\/kp.2016.0141"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"SWEENEY MO, VAN BOMMEL RJ, SCHALIJ MJ, BORLEFFS CJ, HELLKAMP AS, BAX JJ: Analysis of ventricular activation using surface electrocardiography to predict left ventricular reverse volumetric remodeling during cardiac resynchronization therapy. Circulation 121: 626-634, 2010.","DOI":"10.1161\/circulationaha.109.894774"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"VARMA N, O'DONNELL D, BASSIOUNY M, RITTER P, PAPPONE C, MANGUAL J, CANTILLON D, BADIE N, THIBAULT B, WISNOSKEY B: Programming cardiac resynchronization therapy for electrical synchrony: reaching beyond left bundle branch block and left ventricular activation delay. J Am Heart Assoc 7: pii: e007489, 2018.","DOI":"10.1161\/jaha.117.007489"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"WALDEYER C, FABRITZ L, FORTMUELLER L, GERSS J, DAMKE D, BLANA A, LAAKMANN S, KREIENKAMP N, VOLKERY D, BREITHARDT G, KIRCHHOF P: Regional, age-dependent, and genotype-dependent differences in ventricular action potential duration and activation time in 410 Langendorff-perfused mouse hearts. Basic Res Cardiol 104: 523-533, 2009.","DOI":"10.1007\/s00395-009-0019-1"}],"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T04:19:15Z","timestamp":1664943555000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomed.cas.cz\/physiolres\/pdf\/67\/67_S601.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,19]]},"references-count":19,"URL":"https:\/\/doi.org\/10.33549\/physiolres.934056","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12,19]]}}}