{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:08:13Z","timestamp":1773306493251,"version":"3.50.1"},"reference-count":34,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Erectile dysfunction (ED) and diabetes mellitus (DM) share common pathophysiological risk factors including endothelial dysfunction which together with hyperglycemia contribute to the increased oxidative\/glycooxidative stress. A reduced NO concentration is insufficient for relaxation processes in the penis. Chronic inflammation and endoglin are involved in the regulation of endothelial function. Adiponectin from the adipose tissue has anti-inflammatory effects. Our study aimed to investigate the relation between erectile function in patients with and without DM and the oxidative stress, hormone adiponectin, and endothelial dysfunction marker endoglin. Men (n=32) with ED evaluated by the International Index of Erectile function (IIEF-5) questionnaire (17 without DM (NDM); 15 with type 2 diabetes mellitus (DM)) and 31 controls were included. Advanced glycation end products (AGEs), 8-isoprostanes (8-isoP), protein carbonyls, antioxidant capacity, adiponectin and endoglin were determined in the blood. DM patients compared to NDM patients and controls, had increased levels of glucose, C-reactive protein, triacylglycerols, 8-isoP, AGEs, endoglin and BMI. IIEF-5 score, NO and adiponectin levels were decreased. We are the first to find out that endoglin shows a negative correlation with erectile function in NDM, but not in DM patients. Endoglin can be considered as endothelial dysfunction marker in nondiabetic men suffering from ED.<\/jats:p>","DOI":"10.33549\/physiolres.934129","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T13:39:23Z","timestamp":1566913163000},"page":"623-631","source":"Crossref","is-referenced-by-count":16,"title":["Role of oxidative stress, adiponectin and endoglin in the pathophysiology of erectile dysfunction in diabetic and non-diabetic men"],"prefix":"10.33549","author":[{"given":"B.","family":"Trebatick\u00fd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"\u017dit\u0148anov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Dvo\u0159\u00e1kov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Orsz\u00e1ghov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Paduchov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"\u010eura\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Breza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Muchov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2019,8,26]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"BAUMH\u00c4KEL M, SCHLIMMER N, KRATZ MT, B\u00d6HM M: Erektile dysfunktion: indikator f\u00fcr endorgansch\u00e4digung beim kardiovaskul\u00e4ren patienten (In German). Med Klin 104: 309-313, 2009.","DOI":"10.1007\/s00063-009-1051-5"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"BL\u00c1ZQUEZ-MEDELA AM, GARC\u00cdA-ORTIZ L, G\u00d3MEZ-MARCOS MA, RECIO-RODR\u00cdGUEZ JI, S\u00c1NCHEZ-RODR\u00cdGUEZ A, L\u00d3PEZ-NOVOA JM, MART\u00cdNEZ-SALGADO C: Increased plasma soluble endoglin levels as an indicator of cardiovascular alteration ns in hypertensive and diabetic patients. BMC Med 8: 86, 2010.","DOI":"10.1186\/1741-7015-8-86"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"BUCALA R, TRACEY KJ, CERAMI A: Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest 87: 432-438, 1991.","DOI":"10.1172\/jci115014"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"BUSS H, CHAN TP, SLUIS KB, DOMINGAN NM, WINTERBOURN CC: Protein carbonyl measurement by a sensitive ELISA method. Free Radic Biol Med 23: 361-366, 1997.","DOI":"10.1016\/s0891-5849(97)00104-4"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"CAO H: Adipocytokines in obesity and metabolic disease. J Endocrinol 220: T47-T59, 2014.","DOI":"10.1530\/joe-13-0339"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"CASTELA A, GOMES P, DOMINGUES VF, PA\u00cdGA P, COSTA R, VENDEIRA P, COSTA C: Role of oxidative stress-induced systemic and cavernosal molecular alterations in the progression of diabetic erectile dysfunction. J Diabetes 7: 393-401, 2015.","DOI":"10.1111\/1753-0407.12181"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"DEROSA G, ROMANO D, TINELLI C, D'ANGELO A, MAFFIOLI P: Prevalence and associations of erectile dysfunction in a sample of Italian males with type 2 diabetes. Diabetes Res Clin Pract 108: 329-335, 2015.","DOI":"10.1016\/j.diabres.2015.01.037"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"\u010eURA\u010cKOV\u00c1 Z: Free radicals and antioxidants for non-experts. In: Systems Biology of Free Radicals and Antioxidants. I LAHER (ed). Springer-Verlag Berlin Heidelberg, 2014, pp. 3-38.","DOI":"10.1007\/978-3-642-30018-9_2"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"\u010eURA\u010cKOV\u00c1 Z: Some current insights into oxidative stress. Physiol Res 59: 459-469, 2010.","DOI":"10.33549\/physiolres.931844"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"EMEKSIZ HC, BIDECI A, DAMAR \u00c7, DERINKUYU B, \u00c7ELIK N, D\u00d6\u011eER E, Y\u00dcCE \u00d6, \u00d6ZMEN MC, \u00c7AMURDAN MO, CINAZ P: Soluble endoglin level increase occurs prior to development of subclinical structural vascular alterations in diabetic adolescents. J Clin Res Pediatr Endocrinol 8: 313-320, 2016.","DOI":"10.4274\/jcrpe.2906"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"ESPOSITO K, GIUGLIANO F, MARTED\u00cc E, FEOLA G, MARFELLA R, D'ARMIENTO M, GIUGLIANO D: High proportions of erectile dysfunction in men with the metabolic syndrome. Diabetes Care 28: 1201-1203, 2005.","DOI":"10.2337\/diacare.28.5.1201"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"FELDMAN HA, GOLDSTEIN I, HATZICHRISTOU DG, KRANE RJ, MCKINLAY JB: Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J Urol 151: 54-61, 1994.","DOI":"10.1016\/s0022-5347(17)34871-1"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"GHOSHAL K, BHATTACHARYYA M: Adiponectin. Probe of the molecular paradigm associating diabetes and obesity. World J Diabetes 15: 151-166, 2015.","DOI":"10.4239\/wjd.v6.i1.151"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"GREENSTEIN A, CHEN J, MILLER H, MATZKIN H, VILLA Y, BRAF Z: Does severity of ischemic coronary disease correlate with erectile function? J Impot Res 9: 123-126, 1997.","DOI":"10.1038\/sj.ijir.3900282"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"HAN TS, TAJAR A, O'NEILL TW, JIANG M, BARTFAI G, BOONEN S, CASANUEVA F, FINN JD, FORTI G, GIWERCMAN A, HUHTANIEMI IT, KULA K, PENDLETON N, PUNAB M, SILMAN AJ, VANDERSCHUEREN D, LEAN ME, WU FC; EMAS GROUP: Impaired quality of life and sexual function in overweight and obese men: the european male ageing study. Eur Endocrinol 164: 1003-1011, 2011.","DOI":"10.1530\/eje-10-1129"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"HOUSA D, HOUSOV\u00c1 J, VERNEROV\u00c1 Z, HALUZ\u00cdK M. Adipocytokines and cancer. Physiol Res 55: 233-244, 2006.","DOI":"10.33549\/physiolres.930848"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"JAKU\u0160 V, RIETBROCK N: Advanced glycation end-products and the progress of diabetic vascular complications. Physiol Res 53: 131-142, 2004.","DOI":"10.33549\/physiolres.930430"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"JAKU\u0160 V, S\u00c1NDOROV\u00c1 E, KALNINOV\u00c1 J, KRAHULEC B: Monitoring of glycation, oxidative stress and inflammation in relation to the occurrence of vascular complications in patients with type 2 diabetes mellitus. Physiol Res 63: 297-309, 2014.","DOI":"10.33549\/physiolres.932672"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"JAND\u00cdKOV\u00c1 H, DU\u015aKOV\u00c1 M, ST\u00c1RKA L: The influence of smoking and cessation on the human reproductive hormonal balance. Physiol Res 66: S323-S331, 2017.","DOI":"10.33549\/physiolres.933724"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"KALOUSOV\u00c1 M, SKRHA J, ZIMA T: Advanced glycation end-products and advanced oxidation protein products in patients with diabetes mellitus. Physiol Res 51: 597-604, 2002.","DOI":"10.1159\/000066956"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"KAMENOV ZA: A comprehensive review of erectile dysfunction in men with diabetes. Exp Clin Endocrinol Diabetes 123: 141-158, 2015.","DOI":"10.1055\/s-0034-1394383"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"KOBAYASHI H, OUCHI N, KIHARA S, WALSH K, KUMADA M, ABE Y, FUNAHASHI T, MATSUZAWA Y: Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res 94: 27-31, 2004.","DOI":"10.1161\/01.res.0000119921.86460.37"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"LAUMANN EO, WAITE LJ: Sexual dysfunction among older adults: prevalence and risk factors from a nationally representative U.S. probability sample of men and women 57-85 years of age. J Sex Med 5: 2300-2311, 2008.","DOI":"10.1111\/j.1743-6109.2008.00974.x"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"LI S, SHIN HJ, DING EL, VAN DAM RM: Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 302: 179-188, 2009.","DOI":"10.1001\/jama.2009.976"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"MAIORINO MI, BELLASTELLA G, ESPOSITO K: Diabetes and sexual dysfunction: current perspectives. Diabetes Metab Syndr Obes 7: 95-105, 2014.","DOI":"10.2147\/dmso.s36455"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"MAIORINO MI, BELLASTELLA G, GIUGLIANO D, ESPOSITO K: From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome. J Endocrinol Invest 41: 1249-1258, 2018. doi: 10.1007\/s40618-018-0872-6.","DOI":"10.1007\/s40618-018-0872-6"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"MELMAN A, REHMAN J: Pathophysiology of erectile dysfunction. Mol Urol 3: 87-102, 1999.","DOI":"10.1007\/978-1-4613-1105-8_1"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"MONTORSI P, RAVAGNANI PM, GALLI S, ALI SG, BRIGANTI A, SALONIA A, MONTORSI F: The triad of endothelial dysfunction, cardiovascular disease and erectile dysfunction: Clinical Implications. European Urology Supplements 8: 58-66, 2009.","DOI":"10.1016\/j.eursup.2008.10.010"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"MUSICKI B, BURNETT AL: Constitutive NOS uncoupling and NADPH oxidase upregulation in the penis of type 2 diabetic me with erectile dysfunction. Andrology 5: 294-298, 2017.","DOI":"10.1111\/andr.12313"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"RE R, PELLEGRINI N, PROTEGGENTE A, PANNALA A, YANG M, RICE-EVANS C: Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26: 1231-1237, 1999.","DOI":"10.1016\/s0891-5849(98)00315-3"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"RHODEN EL, TEL\u00d6KEN C, SOGARI PR, VARGAS SOUTO CA: The use of the simplified International Index of Erectile Function (IIEF-5) as a diagnostic tool to study the prevalence of erectile dysfunction. Int J Impot Res 14: 245-250, 2002.","DOI":"10.1038\/sj.ijir.3900859"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"SITTE N, MERKER K, GRUNE T: Proteasome-dependent degradation of oxidized proteins in MRC-5 fibroblasts. FEBS Lett 440: 399-402, 1998.","DOI":"10.1016\/s0014-5793(98)01495-1"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"TSUDA K: Roles of adiponectin and oxidative stress in the regulation of membrane microviscosity of red blood cells in hypertensive men-an electron spin resonance study. J Obes Art 548140, 2011. doi: 10.1155\/2011\/548140.","DOI":"10.1155\/2011\/548140"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"WANG X, BAO W, LIU J, OUYANG YY, WANG D, RONG S, XIAO X, SHAN ZL, ZHANG Y, YAO P, LIU LG: Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 36: 166-175, 2013.","DOI":"10.2337\/dc12-0702"}],"container-title":["Physiological Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T13:14:32Z","timestamp":1695129272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomed.cas.cz\/physiolres\/pdf\/2019\/68_623.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":34,"URL":"https:\/\/doi.org\/10.33549\/physiolres.934129","relation":{},"ISSN":["1802-9973","0862-8408"],"issn-type":[{"value":"1802-9973","type":"electronic"},{"value":"0862-8408","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}