{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:09:58Z","timestamp":1780614598021,"version":"3.54.1"},"reference-count":26,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"abstract":"<jats:p>This study aims to investigate serum makorin ring finger protein 3 (MKRN3) levels in girls with idiopathic central precocious puberty (ICPP) and premature thelarche (PT), in order to determine whether circulating MKRN3 level is associated with ICPP and PT. A total of 90 girls were enrolled in the study. 30 age-matched girls were allocated for each group (ICPP, PT and healthy controls [HC], respectively). The base LH (B-LH) and E2 levels were higher in ICPP girls than those in HC and PT girls. The peak LH (P-LH) levels and P-LH\/P-FSH values were obviously higher in ICPP girls than those in PT girls, while higher peak FSH (P-FSH) levels were detected in PT girls when compared to those in ICPP girls. Kisspeptin levels were lower in HC girls than those in ICPP and PT girls. MKRN3 levels were the highest in HC girls among the three groups. There were relatively strong negative correlations among MKRN3, kisspeptin and P-LH\/P-FSH. Circulating MKRN3 can have an important role in the onset of ICPP and PT. However, this should not be used as an independent diagnostic criterion for diagnosing ICPP or differentiating ICPP from PT, but should be used only as an adjunctive diagnostic biomarker.<\/jats:p>","DOI":"10.33549\/physiolres.934222","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T07:19:47Z","timestamp":1583479187000},"page":"127-133","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of Serum Makorin Ring Finger Protein 3 (MKRN3) Levels in Girls With Idiopathic Central Precocious Puberty and Premature Thelarche"],"prefix":"10.33549","author":[{"given":"W.","family":"GE","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-L.","family":"WANG","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Second Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-J.","family":"SHAO","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-W.","family":"LIU","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.-Y.","family":"XU","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ABACI A, \u00c7ATLI G, ANIK A, K\u00dcME T, \u00c7ALAN \u00d6G, D\u00dcNDAR BN, B\u00d6BER E: Significance of serum neurokinin B and kisspeptin levels in the differential diagnosis of premature thelarche and idiopathic central precocious puberty. Peptides 64: 29-33, 2015. https:\/\/doi.org\/10.1016\/j.peptides.2014.12.011","DOI":"10.1016\/j.peptides.2014.12.011"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"ABREU AP, DAUBER A, MACEDO DB, NOEL SD, BRITO VN, GILL JC, CUKIER P, THOMPSON IR, NAVARRO VM, GAGLIARDI PC, RODRIGUES T, KOCHI C, LONGUI CA, BECKERS D, DE ZEGHER F, MONTENEGRO LR, MENDONCA BB, CARROLL RS, HIRSCHHORN JN, LATRONICO AC, KAISER UB: Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med 368: 2467-2475, 2013. https:\/\/doi.org\/10.1056\/NEJMoa1302160","DOI":"10.1056\/nejmoa1302160"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"AKINCI A, CETIN D, ILHAN N: Plasma kisspeptin levels in girls with premature thelarche. J Clin Res Pediatr Endocrinol 4: 61-65, 2012. https:\/\/doi.org\/10.4274\/jcrpe.615","DOI":"10.4274\/jcrpe.615"},{"key":"ref3","unstructured":"ATTA I, LAGHARI TM, KHAN YN, LONE SW, IBRAHIM M, RAZA J: Precocious puberty in children. 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