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Sesame lignans were administered intragastrically at 2 and 20 mg\/kg, and after 60 min, the sympathetic nerve activity was observed to increase by 45.2 % and 66.1 %, respectively. A significant increase in blood flow (39.6 %) was also observed for the 20-mg\/kg dose when measured at 55 min after administration. These sympathomimetic effects were completely prevented by subdiaphragmatic vagotomy, and the increase in blood flow was eliminated in the presence of the \u03b22-adrenergic receptor inhibitor butoxamine. Thus, it is proposed that sesame lignans can increase the blood flow of skeletal muscle, possibly by exciting sympathetic nerve activity through the afferent vagal nerve.<\/jats:p>","DOI":"10.33549\/physiolres.934277","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T14:13:03Z","timestamp":1588774383000},"page":"253-260","source":"Crossref","is-referenced-by-count":8,"title":["Sesame lignans increase sympathetic nerve activity and blood flow in rat skeletal muscles"],"prefix":"10.33549","author":[{"given":"K.","family":"Egawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Horii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Misonou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Takemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Rogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nagai","sequence":"additional","affiliation":[{"name":"ANBAS Corporation, Toyosaki Kita-ku, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"AMANO M, OIDA E, MORITANI T: Age-associated alteration of sympatho-vagal balance in a female population assessed through the tone-entropy analysis. 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