{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:37:08Z","timestamp":1764401828974},"reference-count":36,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2019,10,31]]},"abstract":"<jats:p>Remifentanil is ultrashort-acting opioid with a unique pharmacokinetic profile. It is used exclusively intravenously. While considering its rapid onset of action and other pharmacokinetic properties, we decided to assess its effects following administration via non-traditional routes. Rabbits (n=10 per each group) were randomized into six groups: remifentanil 1 \u03bcg\/kg and 3 \u03bcg\/kg IM, 5.0 and 10.0 \u03bcg\/kg conjunctivally, and 10 \u03bcg\/kg and 25.0 \u03bcg\/kg intranasally. Sedating effects were assessed via a loss of the righting reflex. Secondary, mean arterial blood pressure, arterial oxygen saturation of hemoglobin, and pulse rate was monitored in all rabbits. Non-traditional routes of administration were shown to provide a rapid onset of action as well as fast recovery. Importantly, the administration of remifentanil did not result in any deterioration of cardiovascular functions.<\/jats:p>","DOI":"10.33549\/physiolres.934330","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T14:41:39Z","timestamp":1574952099000},"page":"S97-S103","source":"Crossref","is-referenced-by-count":4,"title":["Non-Traditional Administration of Remifentanil in an Experimental Setting"],"prefix":"10.33549","author":[{"given":"A.","family":"KURZOV\u00c1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"M\u00c1LEK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"HESS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"JA\u010cEK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"SL\u00cdVA","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Third Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2019,11,3]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"AUSEMS ME, HUG CC JR, STANSKI DR, BURM AGL: Plasma concentrations of alfentanil required to supplement nitrous oxide anesthesia for general surgery. 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