{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:46:18Z","timestamp":1762659978082},"reference-count":32,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2020,6,30]]},"abstract":"<jats:p>To investigate the effect of vanadyl trehalose (VT) on oxidative stress and reduced glutathione\/glutathione-S-transferase (GSH\/GSTs) pathway gene expression in mouse gastrointestinal tract, as well as the protective effects of vitamin C (VC) and reduced glutathione (GSH). Thirty male Kunming mice were randomly divided into five groups: control group (group A), VT group (group B), VC + VT group (group C), GSH + VT group (group D) and VC + GSH + VT group (group E). The content of reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) activity and the expressions of glutamate-cysteine ligase catalytic subunit (GCLC), glutathione synthetase (GSS), regulated through glutathione reductase (GSR) and glutathione-S-transferase pi (GSTpi) in stomach and duodenum in vanadyl trehalose treated group were lower than those in group A (P&lt;0.05). The C, D, E group can significantly improve the above indicators, but those only in the stomach in E group reached the level of the control group. Vanadyl trehalose (VT) was able to cause oxidative stress damage to the gastrointestinal tract of mice, which affects GSH content and GSH-Px activity and interferes with the normal expression of GSH\/GSTs pathway. Exogenous vitamin C, reduced glutathione and the combination of the two could play a specific role in antioxidant protection and reduce the toxicity of vanadyl trehalose.<\/jats:p>","DOI":"10.33549\/physiolres.934370","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T11:49:42Z","timestamp":1596196182000},"page":"481-490","source":"Crossref","is-referenced-by-count":1,"title":["Study on the Pharmacological Character of an Insulin-Mimetic Small Molecular Compound of Vanadyl Trehalose"],"prefix":"10.33549","author":[{"given":"M","family":"UMAR","sequence":"first","affiliation":[{"name":"Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, Life Science College, Nankai University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"QIAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"LIU","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, Life Science College, Nankai University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"XING","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, Life Science College, Nankai University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"LI","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, Life Science College, Nankai University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"YANG","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, Life Science College, Nankai University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"FAN","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, Life Science College, Nankai University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"MA","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, Life Science College, Nankai University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"JIANG","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, Life Science College, Nankai University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"LI","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bioactive Materials of the Ministry of Education, Institute of Molecular Biology, Life Science College, Nankai University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"BARRIO DA, WILLIAMS PA, CORTIZO AM: Synthesis of a new vanadyl (IV) complex with trehalose (Trevo): insulin-mimetic activities in osteoblast-like cells in culture. 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