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Because current antitussives have limited efficacy and unwanted side effects there is a continual demand for the development of a novel more effective antitussives for a new efficacious and safe cough treatment. Therefore, inhibiting the activity of these vagal C-fibers represents a rational approach to the development of effective antitussive drugs. This may be achieved by blocking inflammatory mediator receptors or by blocking the generator potential associated with the specific ion channels. Because voltage-gated sodium channels (NaVs) are absolutely required for action potentials initiation and conduction irrespective of the stimulus, NaVs become a promising neural target. There is evidence that NaV1.7, 1.8 and 1.9 subtypes are predominantly expressed in airway cough-triggering nerves. The advantage of blocking these NaVs is suppressing C-fiber irrespective to stimuli, but the disadvantage is that by suppressing the nerves is may also block beneficial sensations and neuronal reflex behavior. The concept is that new antitussive drugs would have the benefit of targeting peripheral airway nociceptors without inhibiting the protective cough reflex.<\/jats:p>","DOI":"10.33549\/physiolres.934395","type":"journal-article","created":{"date-parts":[[2020,3,29]],"date-time":"2020-03-29T12:48:37Z","timestamp":1585486117000},"page":"S7-S18","source":"Crossref","is-referenced-by-count":14,"title":["The Prospect for Potent Sodium Voltage-Gated Channel Blockers to Relieve an Excessive Cough"],"prefix":"10.33549","author":[{"given":"M.","family":"Brozmanova","sequence":"first","affiliation":[{"name":"(Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Pavelkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ADCOCK JJ, DOUGLAS GJ, GARABETTE M, GASCOIGNE M, BEATCH G, WALKER M, PAGE CP: RSD931, a novel anti-tussive agent acting on airway sensory nerves. 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