{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T11:33:26Z","timestamp":1770550406634,"version":"3.49.0"},"reference-count":38,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2020,3,27]]},"abstract":"<jats:p>We studied the effects of GABA receptor agonists microinjections in medullary raph\u00e9 on the mechanically induced tracheobronchial cough response in anesthetized, unparalyzed, spontaneously breathing cats. The results suggest that GABA-ergic inhibition significantly contributes to the regulation of cough reflex by action of both GABAA and GABAB receptors. The data are consistent with inhomogeneous occurrence of GABA-ergic neurons in medullary raph\u00e9 and their different involvement in the cough reflex control. Cells within rostral nucleus raph\u00e9 obscurus with dominant role of GABAA receptors and neurons of rostral nucleus raph\u00e9 pallidus and caudal nucleus raph\u00e9 magnus with dominant role of GABAB receptors participate in regulation of cough expiratory efforts. These cough control elements are distinct from cough gating mechanism. GABA-ergic inhibition in the raph\u00e9 caudal to obex had insignificant effect on cough. Contradictory findings for GABA, muscimol and baclofen administration in medullary raph\u00e9 suggest involvement of coordinated activity of GABA on multiple receptors affecting raph\u00e9 neurons and\/or the local neuronal circuits in the raph\u00e9 modulating cough motor drive.<\/jats:p>","DOI":"10.33549\/physiolres.934401","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T08:04:06Z","timestamp":1585555446000},"page":"S151-S161","source":"Crossref","is-referenced-by-count":3,"title":["Modulation of Cough Reflex by Gaba-Ergic Inhibition in Medullary Raph\u00e9 of the Cat"],"prefix":"10.33549","author":[{"given":"L.","family":"Martvon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Kotmanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Dobrolubov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Babalova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Simera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Veternik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Pitts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jakus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Poliacek","sequence":"additional","affiliation":[{"name":"Institute of Medical Biophysics, Jessenius Faculty of Medicine in Martin, Comenius University Bratislava, Martin, Slovakia. Ivan.Poliacek@jfmed.uniba.sk"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19169","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"AOKI M, SATO Y, NAKAZONO Y, KOHAMA I: Effects of GABA receptor antagonists on the raphe magnus-induced inhibition of bulbar and spinal respiratory neural activities in the cat. Adv Exp Med Biol 393: 33-38, 1995. https:\/\/doi.org\/10.1007\/978-1-4615-1933-1_7","DOI":"10.1007\/978-1-4615-1933-1_7"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"BAEKEY DM, MORRIS KF, NUDING SC, SEGERS LS, LINDSEY BG, SHANNON R: Medullary raphe neuron activity is altered during fictive cough in the decerebrate cat. J Appl Physiol 94: 93-100, 2003. https:\/\/doi.org\/10.1152\/japplphysiol.00341.2002","DOI":"10.1152\/japplphysiol.00341.2002"},{"key":"ref2","unstructured":"BERMAN AL: The Brain Stem of the Cat: A Cytoarchitectonic Atlas With Stereotaxic Coordinates. 1 ed. 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