{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:08:33Z","timestamp":1787026113528,"version":"build-2736575974"},"reference-count":39,"publisher":"Institute of Physiology of the Czech Academy of Sciences","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Res"],"published-print":{"date-parts":[[2020,9,30]]},"abstract":"<jats:p>Midazolam is a short acting sedative with small number of adverse effects. Administered orally, it is currently the most common form of conscious sedation in children. The objective of this paper is to describe effect of midazolam administered to children during dental treatment on their vital signs, and to monitor changes in children\u2019s behavior. We described values of vital signs and behavior in 418 sedations conducted in 272 children between 1-12 years of age. To achieve the following results, we used data from 272 all first-time sedations. After administration of midazolam arterial blood pressure and blood oxygen saturation decreased by values which were not clinically significant. The heart rate increased, with values staying within the limits of physiological range. The speed of onset of midazolam\u2019s clinical effects depends on age and dose. The lower age and dose correlated with the higher behavior score. The effectiveness of midazolam treatment is 97.8 %. Unwillingness of child to receive midazolam is predictor for disruptive behavior during sedation. 1.8 % of all sedation cases showed paradoxical reactions. The administration of midazolam in dose of 0.5 mg per 1 kg of child\u2019s body weight is safe and could be recommended for dental treatment in pediatric dentistry.<\/jats:p>","DOI":"10.33549\/physiolres.934511","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T08:12:30Z","timestamp":1602835950000},"page":"S305-S314","source":"Crossref","is-referenced-by-count":21,"title":["Midazolam and Its Effect on Vital Signs and Behavior in Children Under Conscious Sedation in Dentistry"],"prefix":"10.33549","author":[{"given":"J.","family":"VASAKOVA","sequence":"first","affiliation":[{"name":"Institute of Dental Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"DUSKOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"LUNACKOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"DRAPALOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"ZUZANKOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"STARKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"DUSKOVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"BROUKAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"19169","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ALWIN NP, MURRAY JJ, BRITTON PG: An assessment of dental anxiety in children. 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